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CHARACTERIZATION OF AROMATIC HEPTAENE MACROLIDE ANTIBIOTICS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

W. MECHLINSKI, C. P. SCHAFFNER

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W. MECHLINSKI
Waksman Institute of Microbiology, Rutgers - The State University
C. P. SCHAFFNER
Waksman Institute of Microbiology, Rutgers - The State University

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1980 Volume 33Issue 6Pages 591-599

DOIhttps://doi.org/10.7164/antibiotics.33.591

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Published: 1980Received: November 14, 1979Available on J-STAGE: April 12, 2006Accepted: -Advance online publication: -Revised: -

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Abstract

High performance liquid chromatographic (HPLC) procedures were utilized for the rapid and efficient separation and characterization of the aromatic heptaene macrolide group of antifungal antibiotics. The instrument utilized a 350nm phosphor converted ultraviolet detector and a μ Bondapak C₁₈ column packing. Optimum resolution of eleven commercial aromatic heptaene macrolide preparations was obtained with solvent systems consisting of mixtures of acetonitrile and 0.05 M aqueous sodium citrate buffer, pH 5.3. The presence of two distinct types of aromatic heptaene macrolides with numerous well-defined individual components has been established.

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