Movatterモバイル変換

Nippon Jibiinkoka Gakkai Kaiho

Abstract

Falling accidents are a serious nocosomial problem, with balance disorders after the ingestion of hypnoties said to be a cause Based on the results of animal studies, it was postulated that this problem involves the muscle relaxation that is a pharmacological efect of benzodiazepines (BZP). No reports have, to our knowledge, been made of time-course changes in human in body balance after ingestion of hypnoties. Accordingly. we used quazepam (Doral'), a long-acting hypnotic considered to show comparatively weak musele relaxation, to study static balance after drug ingestion in human volunteers Briefly. informed consent was obtained from 8 healthy adults, then a gait analytic system (GangasH) was used to test static balance after drug ingestion Mann and Romberg tests). We also measured circulating drug concen-traion over time. Our results showed that balance disorders occurred after quazepam ingestion with an unstable posture particularly striking. Given the function of quazepam receptors, it is difficult to surmise that balance disorders after drug ingestion were due to the drug's muscle relaxation We surmised that inhibition from the central nervous system in connection with nerves awakening was involved. We found a strong correlation between the manifestation of balance disorders after drug ingestion and circulating drug concentration.

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