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凝血酶

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維基百科,自由的百科全書
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凝血因子II(凝血酶)
人類凝血酶結構,與其抑制劑水蛭素結合在一起[1]
有效結構
PDB直系同源檢索:PDBe,RCSB
PDB查詢代碼列表

1a2c​,1a3b​,1a3e​,1a46​,1a4w​,1a5g​,1a61​,1abi​,1abj​,1ad8​,1ae8​,1afe​,1aht​,1ai8​,1aix​,1awf​,1awh​,1ay6​,1b5g​,1b7x​,1ba8​,1bb0​,1bbr​,1bcu​,1bhx​,1bmm​,1bmn​,1bth​,1c1u​,1c1v​,1c1w​,1c4u​,1c4v​,1c4y​,1c5l​,1c5n​,1c5o​,1ca8​,1d3d​,1d3p​,1d3q​,1d3t​,1d4p​,1d6w​,1d9i​,1de7​,1dit​,1dm4​,1doj​,1dwb​,1dwc​,1dwd​,1dwe​,1dx5​,1e0f​,1eb1​,1eoj​,1eol​,1fpc​,1fph​,1g30​,1g32​,1g37​,1ghv​,1ghw​,1ghx​,1ghy​,1gj4​,1gj5​,1h8d​,1h8i​,1hag​,1hah​,1hai​,1hao​,1hap​,1hbt​,1hdt​,1hgt​,1hlt​,1hut​,1hxe​,1hxf​,1ihs​,1iht​,1jmo​,1jou​,1jwt​,1k21​,1k22​,1kts​,1ktt​,1lhc​,1lhd​,1lhe​,1lhf​,1lhg​,1mh0​,1mu6​,1mu8​,1mue​,1nm6​,1no9​,1nrn​,1nro​,1nrp​,1nrq​,1nrr​,1nrs​,1nt1​,1nu7​,1nu9​,1ny2​,1nzq​,1o0d​,1o2g​,1o5g​,1ook​,1oyt​,1p8v​,1ppb​,1qbv​,1qhr​,1qj1​,1qj6​,1qj7​,1qur​,1rd3​,1riw​,1sb1​,1sfq​,1sg8​,1sgi​,1shh​,1sl3​,1sr5​,1t4u​,1t4v​,1ta2​,1ta6​,1tb6​,1tbz​,1thp​,1thr​,1ths​,1tmb​,1tmt​,1tmu​,1tom​,1tq0​,1tq7​,1twx​,1ucy​,1uma​,1uvs​,1vit​,1vr1​,1vzq​,1w7g​,1way​,1wbg​,1xm1​,1xmn​,1ycp​,1ype​,1ypg​,1ypj​,1ypk​,1ypl​,1ypm​,1z71​,1z8i​,1z8j​,1zgi​,1zgv​,1zrb​,2a0q​,2a2x​,2a45​,2afq​,2ank​,2anm​,2b5t​,2bdy​,2bvr​,2bvs​,2bvx​,2bxt​,2bxu​,2c8w​,2c8x​,2c8y​,2c8z​,2c90​,2c93​,2cf8​,2cf9​,2cn0​,2feq​,2fes​,2gde​,2gp9​,2h9t​,2hgt​,2hnt​,2hpp​,2hpq​,2hwl​,2jh0​,2jh5​,2jh6​,2od3​,2thf​,3hat​,3htc​,4htc​,4thn​,5gds​,7kme​,8kme

標識
代號F2; PT
擴展標識遺傳學176930鼠基因88380同源基因426GeneCards:F2 Gene
EC編號3.4.21.5
基因本體論描述
分子功能·thrombin activity

·receptor binding

·calcium ion binding
細胞成分·extracellular region

·extracellular space

·soluble fraction
生物過程·regulation of progression through cell cycle

·proteolysis
·apoptosis
·caspase activation
·acute-phase response
·tyrosine phosphorylation of STAT protein
·STAT protein nuclear translocation
·multicellular organismal development
·blood coagulation
·response to wounding
·platelet activation
·regulation of blood coagulation

·fibrinolysis
Sources:Amigo /QuickGO
RNA表達模式
更多表達數據
直系同源體
物種人類小鼠
Entrez214714061
EnsemblENSG00000180210ENSMUSG00000027249
UniProtP00734Q3TJ94
mRNA序列NM_000506NM_010168
蛋白序列NP_000497NP_034298
基因位置Chr 11:
46.7 – 46.72 Mb
Chr 2:
91.43 – 91.44 Mb
PubMed查詢[1][2]

凝血酶(英語:ThrombinEC3.4.21.5)是一種「胰蛋白酶樣」絲氨酸蛋白酶蛋白質,在人體中被F2基因所編碼[2][3]。在凝血作用第一級級聯反應中,凝血酶原凝血因子Ⅱ)被蛋白水解性切除以生成凝血酶,級聯反應最終阻止了血液的繼續流失。凝血酶轉而作為一種絲氨酸蛋白酶以使可溶性的纖維蛋白原轉變為不溶性的纖維蛋白,同時催化其他許多與凝血相關的反應。

另見

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參考文獻

[編輯]
  1. ^PDB:2C93​;Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006,49 (4): 1346–55.PMID 16480269.doi:10.1021/jm050850v. 
  2. ^Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987,13 (3): 285–92.PMID 3474786.doi:10.1007/BF01535211. 
  3. ^Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987,26 (19): 6165–77.PMID 2825773.doi:10.1021/bi00393a033. 

深入閱讀

[編輯]

外部連結

[編輯]

Template:凝固作用

消化酶
凝血
補體系統
其它免疫系統
毒液
其它
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 ·2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 ·3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 ·4.1/2/3/4/5/6 ·5.1/2/3/4/5/99 ·6.1-3英語Template:Ligases CO CS and CN/4/5-6
脫氫酶
轉穀氨醯胺酶英語Transglutaminase
核孔蛋白
其他
抗出血藥英語Antihemorrhagic
(凝血)
系統性
維他命K
凝血因子
其他系統
局部
抗纖維蛋白溶解藥英語Antifibrinolytic
描述
疾病
治療
取自 "https://zh.wikipedia.org/w/index.php?title=凝血酶&oldid=88102366"
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