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维基百科自由的百科全书
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TLR4

本页使用了标题或全文手工转换
维基百科，自由的百科全书
TLR4
已知的結構
PDB直系同源搜索:PDBeRCSB
PDBID列表

4G8A、​2Z62、​2Z63、​2Z65、​2Z66、​3FXI、​3UL7、​3UL8、​3UL9、​3ULA

識別號
别名TLR4；, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
外部IDOMIM：603030MGI：96824HomoloGene：41317GeneCards：TLR4
為以下藥物的標靶
resatorvid[1]
基因位置（人类）
9號染色體
染色体9號染色體[2]
9號染色體
TLR4的基因位置
TLR4的基因位置
基因座9q33.1起始117,704,175bp[2]
终止117,724,735bp[2]
基因位置（小鼠）
小鼠4号染色体
染色体小鼠4号染色体[3]
小鼠4号染色体
TLR4的基因位置
TLR4的基因位置
基因座4 C1|4 34.66 cM起始66,745,821bp[3]
终止66,848,521bp[3]
RNA表达模式
查阅更多表达数据
基因本體
分子功能•lipopolysaccharide immune receptor activity
•lipopolysaccharide binding
•血浆蛋白结合
•transmembrane signaling receptor activity
細胞組分•細胞質
•膜
•细胞质的核周区域
•cell surface
•integral component of membrane
•细胞膜
•endosome membrane
•intrinsic component of plasma membrane
•integral component of plasma membrane
•lipopolysaccharide receptor complex
•external side of plasma membrane
生物學過程•positive regulation of MHC class II biosynthetic process
•positive regulation of JNK cascade
•TRIF-dependent toll-like receptor signaling pathway
•cellular response to mechanical stimulus
•positive regulation of interleukin-8 production
•positive regulation of ERK1 and ERK2 cascade
•T-helper 1 type immune response
•positive regulation of platelet activation
•positive regulation of interleukin-1 production
•positive regulation of stress-activated MAPK cascade
•positive regulation of NLRP3 inflammasome complex assembly
•positive regulation of interleukin-12 production
•positive regulation of interferon-alpha production
•I-kappaB phosphorylation
•positive regulation of nitric-oxide synthase biosynthetic process
•positive regulation of B cell proliferation
•defense response to bacterium
•positive regulation of interleukin-6 production
•activation of innate immune response
•positive regulation of tumor necrosis factor production
•腫瘤壞死因子產生的負調控
•先天免疫系統
•negative regulation of interleukin-17 production
•I-kappaB kinase/NF-kappaB signaling
•positive regulation of interferon-beta production
•positive regulation of inflammatory response
•toll-like receptor 4 signaling pathway
•positive regulation of macrophage cytokine production
•positive regulation of interleukin-10 production
•immune system process
•astrocyte development
•intestinal epithelial structure maintenance
•positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
•response to lipopolysaccharide
•cellular response to lipoteichoic acid
•positive regulation of NF-kappaB transcription factor activity
•免疫反应
•negative regulation of interleukin-23 production
•regulation of inflammatory response
•positive regulation of chemokine production
•lipopolysaccharide-mediated signaling pathway
•detection of fungus
•positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
•negative regulation of interferon-gamma production
•response to bacterium
•negative regulation of osteoclast differentiation
•B cell proliferation involved in immune response
•positive regulation of nitric oxide biosynthetic process
•negative regulation of interleukin-6 production
•positive regulation of interferon-gamma production
•nitric oxide production involved in inflammatory response
•MyD88-dependent toll-like receptor signaling pathway
•regulation of dendritic cell cytokine production
•positive regulation of gene expression
•negative regulation of ERK1 and ERK2 cascade
•positive regulation of I-kappaB kinase/NF-kappaB signaling
•macrophage activation
•detection of lipopolysaccharide
•cellular response to lipopolysaccharide
•positive regulation of lymphocyte proliferation
•positive regulation of transcription by RNA polymerase II
•MyD88-independent toll-like receptor signaling pathway
•訊息傳遞
•inflammatory response
•defense response to Gram-negative bacterium
•toll-like receptor signaling pathway
•程序性坏死
•apoptotic signaling pathway
•negative regulation of MyD88-independent toll-like receptor signaling pathway
Sources:Amigo /QuickGO
直系同源
物種人類小鼠
Entrez

7099

21898

Ensembl

ENSG00000136869

ENSMUSG00000039005

UniProt

O00206

Q9QUK6

mRNA​序列

NM_138557
​NM_003266
​NM_138554
​NM_138556

NM_021297

蛋白序列

NP_003257
​NP_612564
​NP_612567

NP_067272

基因位置​（UCSC）Chr 9: 117.7 – 117.72 MbChr 4: 66.75 – 66.85 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

Toll样受体4（英語：Toll-like receptor 4）是由人类基因TLR4 编码的蛋白质，是一种膜蛋白质，也被称为CD284（分化簇284，cluster of differentiation 284），是模式识别受体中Toll样受体（TLR）家族的成员，可结合其配体脂多糖（LPS）激活NF-κB信号通路，在先天免疫系統中起到重要作用[6]。

参考文献

[编辑]
  1. ^對toll like receptor 4起作用的藥物；在維基數據上查看/編輯參考. 
  2. ^2.02.12.2GRCh38: Ensembl release 89: ENSG00000136869 -Ensembl, May 2017
  3. ^3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000039005 -Ensembl, May 2017
  4. ^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^Vaure C, Liu Y.A comparative review of toll-like receptor 4 expression and functionality in different animal species. Frontiers in Immunology. 2014-07-10,5: 316.PMC 4090903 可免费查阅.PMID 25071777.doi:10.3389/fimmu.2014.00316. 

外部链接

[编辑]
1-50
51-100
101-150
151-200
201-250
251-300
301-350
信号转导:TLR信号通路
受体
其它胞外分子
胞内分子
衔接体：Myd88（英语：Myd88） ·TRIF（英语：TRIF） ·TIRAP（英语：TIRAP） ·TRAF6（英语：TRAF6） ·TOLLIP（英语：TOLLIP）

IRAK1（英语：IRAK1） ·IRAK4（英语：IRAK4）

IRF3（英语：IRF3）

TLR 3（英语：TLR 3） ·TLR 7（英语：TLR 7） ·TLR 8（英语：TLR 8） ·TLR 9
描述
检索自“https://zh.wikipedia.org/w/index.php?title=TLR4&oldid=65753438”
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