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MK-7264

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MK-7264
法律規範狀態

法律規範	美：Investigational New Drug
识别信息
IUPAC命名法 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
CAS号	1015787-98-0^Y
PubChemCID	24764487
DrugBank	DB15097
ChemSpider	58828660
UNII	6K6L7E3F1L
KEGG	D11349
ChEMBL	ChEMBL3716057
CompTox Dashboard（英语：CompTox Chemicals Dashboard）(EPA)	DTXSID401337212
ECHA InfoCard	100.258.106
化学信息
化学式	C₁₄H₁₉N₅O₄S
摩尔质量	353.4
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
InChI InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) Key:HLWURFKMDLAKOD-UHFFFAOYSA-N

MK-7264（英語：Gefapixant）是一种磺胺类药物，作为嘌呤 P2X受体P2RX3（英语：P2RX3）的拮抗剂，可用于治疗慢性咳嗽（英语：chronic cough）^[1]^[2]^[3]。

^Muccino D, Green S. Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough. Pulmonary Pharmacology & Therapeutics. June 2019,56 ( ): 75–78.PMID 30880151.doi:10.1016/j.pupt.2019.03.006.
^Richards D, Gever JR, Ford AP, Fountain SJ.Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation. British Journal of Pharmacology. July 2019,176 (13): 2279–2291.PMC 6555852 .PMID 30927255.doi:10.1111/bph.14677.
^Marucci G, Dal Ben D, Buccioni M, Martí Navia A, Spinaci A, Volpini R, Lambertucci C. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications. Expert Opinion on Therapeutic Patents. December 2019,29 (12): 943–963.PMID 31726893.doi:10.1080/13543776.2019.1693542.

这是一篇關於呼吸系統的藥理學小作品。您可以通过编辑或修订扩充其内容。

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