Movatterモバイル変換


[0]ホーム

URL:


跳转到内容
维基百科自由的百科全书
搜索

糖蛋白激素α亚基

维基百科,自由的百科全书
Glycoprotein hormones, alpha polypeptide
绒毛膜促性腺激素,α多肽
PDB rendering based on 1dz7.
有效结构
PDB直系同源检索:PDBe,RCSB
PDB查询代码列表

1DZ7​,1E9J​,1FL7​,1HCN​,1HD4​,1HRP​,1QFW​,1XWD​,4AY9

标识
代号CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
扩展标识遗传学118850鼠基因88390同源基因587GeneCards:CGA Gene
基因本体论描述
分子功能·hormone activity
·protein binding
细胞成分·extracellular region
生物过程·thyroid hormone generation

·signal transduction
·cell-cell signaling
·positive regulation of cell proliferation
·gonad development
·peptide hormone processing
·positive regulation of cell migration
·thyroid gland development
·luteinizing hormone secretion
·cellular response to hormone stimulus
·cellular protein metabolic process
·positive regulation of transcription from RNA polymerase II promoter
·negative regulation of organ growth
·follicle-stimulating hormone secretion

·developmental growth
Sources:Amigo /QuickGO
RNA表达模式
更多表达数据
直系同源体
物种人类小鼠
Entrez108112640
EnsemblENSG00000135346ENSMUSG00000028298
UniProtP01215P01216
mRNA序列NM_000735NM_009889
蛋白序列NP_000726NP_034019
基因位置Chr 6:
87.8 – 87.8 Mb
Chr 4:
34.89 – 34.91 Mb
PubMed查询[1][2]

糖蛋白激素α亚基(英語:Alpha subunit of glycoprotein hormones,或称为绒毛膜促性腺激素α亚基Glycoprotein hormones alpha chain)是一个由人类基因CGA 编码的蛋白质[1]

人体的四种糖蛋白激素英语glycoprotein hormones--人绒毛膜促性腺激素(hCG)、黄体生成素(LH)、促卵泡激素(FSH)和促甲状腺激素(TSH)都是以同样的该α亚基和各自不同的β亚基组成的二聚体。[2]化学式为[3]:C561H876O224N130S13[4]

此α链的92个氨基酸残基的序列为:

NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

参考文献

[编辑]
  1. ^Fiddes JC, Goodman HM. The gene encoding the common alpha subunit of the four human glycoprotein hormones. J Mol Appl Genet. Oct 1982,1 (1): 3–18.PMID 6286817. 
  2. ^Entrez Gene: CGA glycoprotein hormones, alpha polypeptide. (原始内容存档于2010-12-05). 
  3. ^Expasy - ProtParam. web.expasy.org. [2025-06-02]. 
  4. ^UniProt. UniProt. [2025-06-02](英语). 

延伸阅读

[编辑]
  • Roger M, Lahlou N, Couzinet B; et al. [Free alpha-subunit glycoprotein hormones: physiological and pathological data]. J. Steroid Biochem. 1990,33 (4B): 763–9.PMID 2481154.doi:10.1016/0022-4731(89)90489-5.  引文格式1维护:显式使用等标签 (link)
  • Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1972,89 (6): 1331–44.PMID 5002675.doi:10.1210/endo-89-6-1331. 
  • Kourides IA, Gurr JA, Wolf O. The regulation and organization of thyroid stimulating hormone genes.. Recent Prog. Horm. Res. 1984,40: 79–120.PMID 6207569. 
  • Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994,52 (4): 940–7.PMID 8196184. 
  • Barrios-De-Tomasi J, Timossi C, Merchant H; et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.. Mol. Cell. Endocrinol. 2002,186 (2): 189–98.PMID 11900895.doi:10.1016/S0303-7207(01)00657-8.  引文格式1维护:显式使用等标签 (link)
  • Moyle WR, Bahl OP, März L. Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action.. J. Biol. Chem. 1976,250 (23): 9163–9.PMID 172504. 
  • Fiddes JC, Goodman HM. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.. Nature. 1979,281 (5730): 351–6.PMID 481597.doi:10.1038/281351a0. 
  • Sairam MR, Li CH. Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.. Can. J. Biochem. 1977,55 (7): 755–60.PMID 890569.doi:10.1139/o77-108. 
  • Morgan FJ, Birken S, Canfield RE. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.. J. Biol. Chem. 1975,250 (13): 5247–58.PMID 1150658. 
  • Rathnam P, Saxena BB. Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit.. J. Biol. Chem. 1975,250 (17): 6735–46.PMID 1158880. 
  • Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.. Eur. J. Biochem. 1991,195 (1): 257–68.PMID 1991473.doi:10.1111/j.1432-1033.1991.tb15702.x. 
  • Sakakibara R, Yokoo Y, Yoshikoshi K; et al. Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.. J. Biochem. 1988,102 (5): 993–1001.PMID 2449427.  引文格式1维护:显式使用等标签 (link)
  • Matzuk MM, Keene JL, Boime I. Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction.. J. Biol. Chem. 1989,264 (5): 2409–14.PMID 2536708. 
  • Lustbader JW, Birken S, Pileggi NF; et al. Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.. Biochemistry. 1990,28 (24): 9239–43.PMID 2611225.doi:10.1021/bi00450a001.  引文格式1维护:显式使用等标签 (link)
  • Harris DC, Machin KJ, Evin GM; et al. Preliminary X-ray diffraction analysis of human chorionic gonadotropin.. J. Biol. Chem. 1989,264 (12): 6705–6.PMID 2708337.  引文格式1维护:显式使用等标签 (link)
  • Hayashizaki Y, Miyai K, Kato K, Matsubara K. Molecular cloning of the human thyrotropin-beta subunit gene.. FEBS Lett. 1985,188 (2): 394–400.PMID 3839756.doi:10.1016/0014-5793(85)80409-9. 
  • Bellisario R, Carlsen RB, Bahl OP. Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.. J. Biol. Chem. 1973,248 (19): 6796–809.PMID 4745444. 
  • Shome B, Parlow AF.Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).. J. Clin. Endocrinol. Metab. 1974,39 (1): 199–202.PMID 4835135.doi:10.1210/jcem-39-1-199. 


糖蛋白激素α亚基引用了美国国家医学图书馆提供的資料,这些資料属于公共领域

内分泌腺
下丘脑-垂体
下丘脑
垂体后叶
垂体前叶
性腺轴
睾丸
卵巢
胎盘
肾上腺轴
甲状腺轴
胰脏
松果體
非内分泌腺
消化系统
十二指肠
回肠
肝脏/其它
循环系统
心脏
其它
脂肪組織
胸腺
骨骼
靶源性
描述
疾病
治療
检索自“https://zh.wikipedia.org/w/index.php?title=糖蛋白激素α亚基&oldid=88274295
分类:​
隐藏分类:​

[8]ページ先頭

©2009-2025 Movatter.jp