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凝血酶

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凝血因子II(凝血酶)
人类凝血酶结构,与其抑制剂水蛭素结合在一起[1]
有效结构
PDB直系同源检索:PDBe,RCSB
PDB查询代码列表

1a2c​,1a3b​,1a3e​,1a46​,1a4w​,1a5g​,1a61​,1abi​,1abj​,1ad8​,1ae8​,1afe​,1aht​,1ai8​,1aix​,1awf​,1awh​,1ay6​,1b5g​,1b7x​,1ba8​,1bb0​,1bbr​,1bcu​,1bhx​,1bmm​,1bmn​,1bth​,1c1u​,1c1v​,1c1w​,1c4u​,1c4v​,1c4y​,1c5l​,1c5n​,1c5o​,1ca8​,1d3d​,1d3p​,1d3q​,1d3t​,1d4p​,1d6w​,1d9i​,1de7​,1dit​,1dm4​,1doj​,1dwb​,1dwc​,1dwd​,1dwe​,1dx5​,1e0f​,1eb1​,1eoj​,1eol​,1fpc​,1fph​,1g30​,1g32​,1g37​,1ghv​,1ghw​,1ghx​,1ghy​,1gj4​,1gj5​,1h8d​,1h8i​,1hag​,1hah​,1hai​,1hao​,1hap​,1hbt​,1hdt​,1hgt​,1hlt​,1hut​,1hxe​,1hxf​,1ihs​,1iht​,1jmo​,1jou​,1jwt​,1k21​,1k22​,1kts​,1ktt​,1lhc​,1lhd​,1lhe​,1lhf​,1lhg​,1mh0​,1mu6​,1mu8​,1mue​,1nm6​,1no9​,1nrn​,1nro​,1nrp​,1nrq​,1nrr​,1nrs​,1nt1​,1nu7​,1nu9​,1ny2​,1nzq​,1o0d​,1o2g​,1o5g​,1ook​,1oyt​,1p8v​,1ppb​,1qbv​,1qhr​,1qj1​,1qj6​,1qj7​,1qur​,1rd3​,1riw​,1sb1​,1sfq​,1sg8​,1sgi​,1shh​,1sl3​,1sr5​,1t4u​,1t4v​,1ta2​,1ta6​,1tb6​,1tbz​,1thp​,1thr​,1ths​,1tmb​,1tmt​,1tmu​,1tom​,1tq0​,1tq7​,1twx​,1ucy​,1uma​,1uvs​,1vit​,1vr1​,1vzq​,1w7g​,1way​,1wbg​,1xm1​,1xmn​,1ycp​,1ype​,1ypg​,1ypj​,1ypk​,1ypl​,1ypm​,1z71​,1z8i​,1z8j​,1zgi​,1zgv​,1zrb​,2a0q​,2a2x​,2a45​,2afq​,2ank​,2anm​,2b5t​,2bdy​,2bvr​,2bvs​,2bvx​,2bxt​,2bxu​,2c8w​,2c8x​,2c8y​,2c8z​,2c90​,2c93​,2cf8​,2cf9​,2cn0​,2feq​,2fes​,2gde​,2gp9​,2h9t​,2hgt​,2hnt​,2hpp​,2hpq​,2hwl​,2jh0​,2jh5​,2jh6​,2od3​,2thf​,3hat​,3htc​,4htc​,4thn​,5gds​,7kme​,8kme

标识
代号F2; PT
扩展标识遗传学176930鼠基因88380同源基因426GeneCards:F2 Gene
EC編號3.4.21.5
基因本体论描述
分子功能·thrombin activity

·receptor binding

·calcium ion binding
细胞成分·extracellular region

·extracellular space

·soluble fraction
生物过程·regulation of progression through cell cycle

·proteolysis
·apoptosis
·caspase activation
·acute-phase response
·tyrosine phosphorylation of STAT protein
·STAT protein nuclear translocation
·multicellular organismal development
·blood coagulation
·response to wounding
·platelet activation
·regulation of blood coagulation

·fibrinolysis
Sources:Amigo /QuickGO
RNA表达模式
更多表达数据
直系同源体
物种人类小鼠
Entrez214714061
EnsemblENSG00000180210ENSMUSG00000027249
UniProtP00734Q3TJ94
mRNA序列NM_000506NM_010168
蛋白序列NP_000497NP_034298
基因位置Chr 11:
46.7 – 46.72 Mb
Chr 2:
91.43 – 91.44 Mb
PubMed查询[1][2]

凝血酶(英語:ThrombinEC3.4.21.5)是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质,在人体中被F2基因所编码[2][3]。在凝血作用第一级级联反应中,凝血酶原凝血因子Ⅱ)被蛋白水解性切除以生成凝血酶,级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白,同时催化其他许多与凝血相关的反应。

另见

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参考文献

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  1. ^PDB:2C93​;Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006,49 (4): 1346–55.PMID 16480269.doi:10.1021/jm050850v. 
  2. ^Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987,13 (3): 285–92.PMID 3474786.doi:10.1007/BF01535211. 
  3. ^Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987,26 (19): 6165–77.PMID 2825773.doi:10.1021/bi00393a033. 

深入阅读

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外部链接

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Template:凝固作用

消化酶
凝血
补体系统
其它免疫系统
毒液
其它
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 ·2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 ·3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 ·4.1/2/3/4/5/6 ·5.1/2/3/4/5/99 ·6.1-3英语Template:Ligases CO CS and CN/4/5-6
脱氢酶
轉麩醯胺酸酶英语Transglutaminase
核孔蛋白
其他
抗出血药英语Antihemorrhagic
(凝血)
系统性
维生素K
凝血因子
其他系统
局部
抗纤维蛋白溶解药英语Antifibrinolytic
描述
疾病
治療
检索自“https://zh.wikipedia.org/w/index.php?title=凝血酶&oldid=88102366
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