Published March 1, 1999 | Version v1
Journal article Open
Microarrays and Toxicology: The Advent of Toxicogenomics
Description
The availability of genome-scale DNA sequence information and reagents has radically altered life-science research. This revolution has led to the development of a new scientific subdiscipline derived from a combination of the fields of toxicology and genomics. This subdiscipline, termed toxicogenomics, is concerned with the identification of potential human and environmental toxicants, and their putative mechanisms of action, through the use of genomics resources. One such resource is DNA microarrays or "chips," which allow the monitoring of the expression levels of thousands of genes simultaneously. Here we propose a general method by which gene expression, as measured by cDNA microarrays, can be used as a highly sensitive and informative marker for toxicity. Our purpose is to acquaint the reader with the development and current state of microarray technology and to present our view of the usefulness of microarrays to the field of toxicology.
Files
article.pdf
Files (176.1 kB)
| Name | Size | Download all |
|---|---|---|
| md5:f112224e59ec69b053f5c7c0258c4d2b | 176.1 kB | PreviewDownload |
432
Views
429
Downloads
Show more details
| All versions | This version | |
|---|---|---|
| Views Total views | 432 | 432 |
| Downloads Total downloads | 429 | 426 |
| Data volume Total data volume | 77.5 MB | 77.0 MB |
Versions
External resources
Indexed in
Communities
Details
- DOI
1098-2744(199903)24%3a3%253C153%3a%3aaid-mc1%253E3.0.co%3b2-p.svg&f=jpg&w=240)
DOI BadgeDOI
10.1002/(sici)1098-2744(199903)24:3<153::aid-mc1>3.0.co;2-p
Markdown
[1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p.svg)](https://doi.org/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p)
reStructuredText
.. image:: https://zenodo.org/badge/DOI/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p.svg :target: https://doi.org/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p
HTML
<a href="https://doi.org/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p"><img src="https://zenodo.org/badge/DOI/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p.svg" alt="DOI"></a>
Image URL
https://zenodo.org/badge/DOI/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p.svg
Target URL
https://doi.org/10.1002/(sici)1098-2744(199903)24:3%3C153::aid-mc1%3E3.0.co;2-p
- Resource type
- Journal article
- Publisher
- Zenodo
Rights
Creative Commons Zero v1.0 UniversalCC0 waives copyright interest in a work you've created and dedicates it to the world-wide public domain. Use CC0 to opt out of copyright entirely and ensure your work has the widest reach.Read more
Citation
Export
Technical metadata
- Created
- April 28, 2018
- Modified
- August 2, 2024