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Approximately 50 representatives from the Centers for Disease Control and Prevention, U.S. Department of Agriculture, and U.S. Food and Drug Administration attended an interagency workshop to develop a collaborative agenda for the control and prevention of human illness caused by multidrug-resistantSalmonella serotype Typhimurium Definitive Type 104 (DT104). Invited speakers from the Minnesota Department of Health, the Schools of Veterinary Medicine at Washington State University and Cornell University, and the ministries of health of the United Kingdom, Canada, and the Netherlands attended the workshop, held in Atlanta, Georgia, in May 1997. Workshop goals were to review the available data on multidrug-resistantS.Typhimurium DT104, identify research needs and available resources to address this emerging public health problem, and outline a strategic plan for the control and prevention of human illness caused by this organism.

Multidrug-resistantS.Typhimurium DT104 resistant to ampicillin, chloramphenicol, sulfonamides, streptomycin, and tetracycline (R-type ACSSuT) were among the most commonSalmonella isolates identified in the United States, Canada, the United Kingdom, and several other European countries in 1996. Data presented at the workshop indicate that multidrug-resistantS. Typhimurium DT104 recently emerged almost simultaneously in North America and Europe; mechanisms for this widespread distribution are not known. In several European countries, the organism is also frequently becoming resistant to trimethoprim and fluoroquinolones.S.Typhimurium DT104 R-type ACSSuT is also causing marked illness in animals, particularly cattle.

Further studies are necessary to elucidate the distribution of S. Typhimurium DT104 in the environment and in the human and animal food chains and to examine additional subtyping techniques, including pulsed-field gel electrophoresis, plasmid profiles, and polymerase chain reaction. In addition, laboratory procedures forS. Typhimurium DT104 (including phage typing techniques and interpretation) need to be standardized. Participants agreed to form an interagency working group to exchange information and assist in allocating resources to address this emerging public health problem.

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