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Membrane metalloendopeptidase(Q414232)

From Wikidata

mammalian protein found in Homo sapiens

CALLA
Neutral endopeptidase
neprilysin
skin fibroblast elastase
membrane metallo-endopeptidase variant 2
neprilysin-390
common acute lymphocytic leukemia antigen
neprilysin-411
neutral endopeptidase 24.11
SFE
atriopeptidase
membrane metallo-endopeptidase variant 1
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
NEP
MME
Enkephalinase

Language	Label	Description	Also known as
default for all languages	No label defined
English	Membrane metalloendopeptidase	mammalian protein found in Homo sapiens	CALLA Neutral endopeptidase neprilysin skin fibroblast elastase membrane metallo-endopeptidase variant 2 neprilysin-390 common acute lymphocytic leukemia antigen neprilysin-411 neutral endopeptidase 24.11 SFE atriopeptidase membrane metallo-endopeptidase variant 1 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) NEP MME Enkephalinase

Statements

1 reference

13 November 2019

UniProt protein ID

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08473

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08473

Enkephalinase (human)

0 references

Peptidase M13, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M13, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

2 references

8 April 2019

Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

zinc ion binding

determination method or standard

1 reference

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

exopeptidase activity

determination method or standard

1 reference

8 April 2019

Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

endopeptidase activity

determination method or standard

4 references

3 January 2017

Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

peptidase activity

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

peptide binding

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

metalloendopeptidase activity

determination method or standard

4 references

8 April 2019

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

metallopeptidase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

phosphatidylserine binding

determination method or standard

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

endopeptidase activity

determination method or standard

9 references

8 April 2019

Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

oligopeptidase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

cardiolipin binding

determination method or standard

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

3 January 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

extracellular exosome

determination method or standard

3 references

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

integral component of membrane

determination method or standard

2 references

8 April 2019

Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

synaptic vesicle

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

plasma membrane

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

neuron projection terminus

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

secretory granule membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

trans-Golgi network

determination method or standard

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

2 references

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

extracellular exosome

determination method or standard

2 references

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

biological process

angiotensin maturation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

cellular response to UV-B

determination method or standard

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

kidney development

determination method or standard

1 reference

3 January 2017

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

replicative senescence

determination method or standard

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

cellular response to UV-A

determination method or standard

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

creatinine metabolic process

determination method or standard

1 reference

8 April 2019

Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

peptide metabolic process

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

amyloid-beta metabolic process

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

6 references

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

3 January 2017

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

determination method or standard

sensory perception of pain

determination method or standard

2 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

kidney development

determination method or standard

2 references

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

placenta development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

12 references

8 April 2019

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

determination method or standard

1 reference

8 April 2019

Neprylisin decreases uniformly in Alzheimer's disease and in normal aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

learning or memory

determination method or standard

1 reference

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

lung development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

positive regulation of neurogenesis

determination method or standard

1 reference

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

neuropeptide processing

determination method or standard

1 reference

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

amyloid-beta clearance

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

amyloid-beta clearance by cellular catabolic process

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

positive regulation of long-term synaptic potentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

determination method or standard

Gene Atlas image

PBB GE MME 203434 s at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P08473

1 reference

Identifiers.org

Peptidase M13, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08473

Peptidase M13, C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08473

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353679

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353679

ENSP00000417079

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417079

ENSP00000418525

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418525

ENSP00000419653

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419653

ENSP00000420389

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420389

ENSP00000478173

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478173

ENSP00000372450

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000372450

ENSP00000417595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417595

ENSP00000418238

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418238

ENSP00000418791

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418791

ENSP00000420101

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420101

ENSP00000420542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420542

ENSP00000480349

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480349

ENSP00000485791

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485791

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(17 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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