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remdesivir(Q28209496)

From Wikidata
chemical compound and antiviral drug
  • GS-5734
  • 2-ethylbutyl (2S)-2-({[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl}amino)propanoate
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    English
    remdesivir
    chemical compound and antiviral drug
    • GS-5734
    • 2-ethylbutyl (2S)-2-({[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl}amino)propanoate
    • Veklury

    Statements

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    Remdesivir.svg
    512 × 432; 11 KB
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    C₂₇H₃₅N₆O₈P
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    Nc3ncnn2c3ccc2C(C#N)(C1O)OC(C1O)CO[P](=O)(NC(C)C(=O)OCC(CC)CC)Oc4ccccc4
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    CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
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    1 reference
    22 January 2022
    The antiviral remdesivir should not be used as treatment for hospitalized Covid-19 patients, the World Health Organization said Thursday, only a month after the Food and Drug Administration approved the drug to treat patients over age 12 who are hospitalized with Covid-19.(English)
    1 reference
    22 January 2022
    Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak.(English)
    1 reference
    FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.(English)
    602.2253987099999dalton
    2 references
    22 January 2022
    WHO has issued a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients.(English)
    22 January 2022
    However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups.(English)
    1 reference
    22 January 2022
    Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak.(English)
    Remdesivir
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    Identifiers

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    EMEA/H/C/005622
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