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heme oxygenase 1
(Q5631153)
Item
Discussion
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From Wikidata
mammalian protein found in Homo sapiens
P32 protein
HO-1
HMOX1
heme oxygenase (decycling) 1
heat shock protein, 32-kD
edit
Language
Label
Description
Also known as
default for all languages
No label defined
–
English
heme oxygenase 1
mammalian protein found in Homo sapiens
P32 protein
HO-1
HMOX1
heme oxygenase (decycling) 1
heat shock protein, 32-kD
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P09601
part of
Haem oxygenase, subgroup
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P09601
Haem oxygenase-like, multi-helical
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P09601
Haem oxygenase conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
image
Protein HMOX1 PDB 1n3u.png
867 × 586; 406 KB
0 references
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P09601
encoded by
HMOX1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P09601
molecular function
phospholipase D activity
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
protein homodimerization activity
determination method or standard
IDA
1 reference
retrieved
26 September 2017
stated in
Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
heme oxygenase (decyclizing) activity
determination method or standard
IDA
TAS
IMP
IEA
6 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
metal ion binding
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
signal transducer activity
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
heme binding
determination method or standard
IDA
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
protein binding
determination method or standard
IPI
2 references
retrieved
26 September 2017
stated in
Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IPI
retrieved
26 September 2017
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IPI
enzyme binding
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
oxidoreductase activity
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cell component
cytosol
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
endoplasmic reticulum membrane
determination method or standard
IEA
TAS
2 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
membrane
determination method or standard
IEA
TAS
2 references
retrieved
26 September 2017
stated in
Human heme oxygenase cDNA and induction of its mRNA by hemin
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
intracellular membrane-bounded organelle
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
nucleolus
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
endoplasmic reticulum
determination method or standard
IDA
ISS
IEA
TAS
6 references
retrieved
26 September 2017
stated in
Human heme oxygenase cDNA and induction of its mRNA by hemin
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
retrieved
26 September 2017
stated in
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
caveola
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
perinuclear region of cytoplasm
determination method or standard
IDA
1 reference
retrieved
26 September 2017
stated in
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
nucleus
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
extracellular space
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
biological process
negative regulation of neuron apoptotic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
apoptotic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cellular iron ion homeostasis
determination method or standard
TAS
IMP
2 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
Haem oxygenase-1 overexpression alters intracellular iron distribution
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
negative regulation of smooth muscle cell proliferation
determination method or standard
IDA
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
cellular response to heat
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
intracellular signal transduction
determination method or standard
IEA
TAS
2 references
retrieved
26 September 2017
stated in
Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of mast cell cytokine production
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
response to hypoxia
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
excretion
determination method or standard
IC
1 reference
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IC
low-density lipoprotein particle clearance
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
small GTPase mediated signal transduction
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of DNA binding
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
response to nicotine
determination method or standard
IDA
1 reference
retrieved
26 September 2017
stated in
Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
iron ion homeostasis
determination method or standard
IDA
IMP
2 references
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
cell death
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
heme oxidation
determination method or standard
IDA
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
negative regulation of mast cell degranulation
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cellular response to cadmium ion
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
regulation of angiogenesis
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
negative regulation of muscle cell apoptotic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
response to oxidative stress
determination method or standard
IEA
IMP
2 references
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of DNA-binding transcription factor activity
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cellular response to nutrient
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
positive regulation of angiogenesis
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
response to estrogen
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
wound healing involved in inflammatory response
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
regulation of blood pressure
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
heme catabolic process
determination method or standard
IDA
IEA
TAS
3 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
retrieved
26 September 2017
stated in
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
erythrocyte homeostasis
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
regulation of DNA-binding transcription factor activity
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cellular response to arsenic-containing substance
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
HO-1 underlies resistance of AML cells to TNF-induced apoptosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
angiogenesis
determination method or standard
IEA
TAS
2 references
retrieved
26 September 2017
stated in
Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
intrinsic apoptotic signaling pathway in response to DNA damage
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
endothelial cell proliferation
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
positive regulation of I-kappaB kinase/NF-kappaB signaling
determination method or standard
IMP
1 reference
retrieved
26 September 2017
stated in
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IMP
smooth muscle hyperplasia
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
protein homooligomerization
determination method or standard
IDA
1 reference
retrieved
26 September 2017
stated in
Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
negative regulation of leukocyte migration
determination method or standard
TAS
1 reference
retrieved
26 September 2017
stated in
Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
TAS
cellular response to hypoxia
determination method or standard
IEP
1 reference
retrieved
26 September 2017
stated in
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEP
response to hydrogen peroxide
determination method or standard
ISS
IEA
2 references
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
ISS
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of cell population proliferation
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
heme metabolic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
positive regulation of smooth muscle cell proliferation
determination method or standard
IDA
1 reference
retrieved
26 September 2017
stated in
BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes
GOA
curator
UniProt
UniProt protein ID
P09601
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IDA
regulation of transcription from RNA polymerase II promoter in response to iron
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
positive regulation of apoptotic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
cellular response to cisplatin
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
positive regulation of macroautophagy
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of vascular associated smooth muscle cell proliferation
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of epithelial cell apoptotic process
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
liver regeneration
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
negative regulation of macroautophagy
determination method or standard
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09601&geneProductId=UniProtKB:P09601
determination method or standard
IEA
physically interacts with
Viroporin 3a
determination method or standard
Affinity Capture-MS
1 reference
reference URL
https://thebiogrid.org/news/227
retrieved
19 April 2020
stated in
BioGRID
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Family with sequence similarity 209 member A
determination method or standard
two-hybrid screening
0 references
Gene Atlas image
PBB GE HMOX1 203665 at fs.png
732 × 530; 11 KB
0 references
has part(s)
Haem oxygenase conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P09601
Identifiers
MeSH descriptor ID
D051547
subject named as
Heme Oxygenase-1
0 references
MeSH tree code
D08.811.682.690.708.410.500
0 references
RefSeq protein ID
NP_002124
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
3162
UniProt protein ID
P09601
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P09601
Ensembl protein ID
ENSP00000216117
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000216117
ENSP00000413316
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000413316
Freebase ID
/m/09lgtl
0 references
OpenAlex ID
C2779730776
1 reference
stated in
OpenAlex
retrieved
26 January 2022
reference URL
https://docs.openalex.org/download-snapshot/snapshot-data-format
PDB structure ID
1N3U
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1N45
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1NI6
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OYK
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OYL
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OZE
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OZL
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OZR
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1OZW
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1S13
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1S8C
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1T5P
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1TWN
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1TWR
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1XJZ
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1XK0
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1XK1
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1XK2
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
1XK3
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
3CZY
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
3HOK
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
3K4F
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
3TGM
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
4WD4
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
5BTQ
1 reference
stated in
UniProt
UniProt protein ID
P09601
retrieved
9 August 2016
language of work or name
English
UMLS CUI
C0538674
1 reference
based on heuristic
inferred by common MeSH mappings on source and on Wikidata
stated in
UMLS 2023
retrieved
25 May 2023
Sitelinks
Wikipedia
(7 entries)
edit
cywiki
HMOX1
enwiki
HMOX1
frwiki
Hème oxygénase 1
ptwiki
HMOX1
srwiki
HMOX1
ukwiki
Гемоксигеназа-1
zhwiki
HMOX1
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
Retrieved from "
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heme oxygenase 1
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