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The role of alpha-synuclein in Parkinson's disease: insights from animal models(Q35209957)

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English	The role of alpha-synuclein in Parkinson's disease: insights from animal models	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

The role of alpha-synuclein in Parkinson's disease: insights from animal models(English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Kathy Steece-Collier

5

object named as

Kathy Steece-Collier

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Jeffrey H Kordower

4

object named as

Jeffrey H Kordower

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

Eleonora Maries

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Biplob Dass

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Timothy J Collier

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

publication date

1 September 2003

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Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

0 references

Nature Reviews Neuroscience

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Europe PubMed Central

PubMed publication ID

7 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

727-738

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

publication type of scholarly work

1 reference

Europe PubMed Central

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The ubiquitin pathway in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Recent advances in the genetics and pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

α-Synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkin and the molecular pathways of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Neurodegenerative disease: amyloid pores from pathogenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

A role for alpha-synuclein in the regulation of dopamine biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Ageing and Parkinson's disease: substantia nigra regional selectivity

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Neuroprotective and neurorestorative strategies for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Generation of reactive oxygen species by the mitochondrial electron transport chain

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Engineered modeling and the secrets of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The mouse MPTP model: gene expression changes in dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Experimental models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkinson's disease, pesticides, and glutathione transferase polymorphisms

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Animal models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Pharmacological prevention of Parkinson disease in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Effects of Pharmacological Agents upon a Transgenic Model of Parkinson’s Disease in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Chaperoning brain degeneration

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

The genome sequence of Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Neuropathology in mice expressing human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Parkinson's disease. Dopamine may sustain toxic protein

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Clinical and neuropathological correlates of Lewy body disease

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

31 March 2020

Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma

1 reference

https://api.crossref.org/works/10.1038%2FNRN1199

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/NRN1199

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Europe PubMed Central

PubMed publication ID

7 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

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