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Phosphodiesterase 4C
(Q21202200)
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From Wikidata
mammalian protein found in Homo sapiens
PDE4C
DPDE1
PDE21
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
dunce-like phosphodiesterase E1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
edit
Language
Label
Description
Also known as
default for all languages
No label defined
–
English
Phosphodiesterase 4C
mammalian protein found in Homo sapiens
PDE4C
DPDE1
PDE21
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
dunce-like phosphodiesterase E1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q08493
subclass of
protein
1 reference
stated in
UniProt
retrieved
1 December 2016
UniProt protein ID
Q08493
part of
3'5'-cyclic nucleotide phosphodiesterase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q08493
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q08493
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
HD/PDEase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q08493
encoded by
PDE4C
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q08493
molecular function
phosphoric diester hydrolase activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
protein binding
determination method or standard
IPI
1 reference
retrieved
31 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08493&geneProductId=UniProtKB:Q08493
determination method or standard
IPI
3',5'-cyclic-nucleotide phosphodiesterase activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
hydrolase activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
metal ion binding
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
3',5'-cyclic-AMP phosphodiesterase activity
determination method or standard
TAS
2 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08493&geneProductId=UniProtKB:Q08493
determination method or standard
TAS
retrieved
31 October 2017
stated in
Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08493&geneProductId=UniProtKB:Q08493
determination method or standard
TAS
3',5'-cyclic-AMP phosphodiesterase activity
determination method or standard
IBA
TAS
2 references
retrieved
8 April 2019
stated in
Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
TAS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IBA
protein binding
determination method or standard
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IBA
cell component
cytosol
determination method or standard
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
TAS
cell projection
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
extracellular space
determination method or standard
IDA
1 reference
retrieved
31 October 2017
stated in
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08493&geneProductId=UniProtKB:Q08493
determination method or standard
IDA
cilium
determination method or standard
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
extracellular space
determination method or standard
HDA
1 reference
retrieved
8 April 2019
stated in
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
HDA
biological process
cAMP catabolic process
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q08493
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
signal transduction
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
IEA
G protein-coupled receptor signaling pathway
determination method or standard
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08493
determination method or standard
TAS
physically interacts with
ibudilast
has use
enzyme inhibitor
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
7399
language of work or name
English
retrieved
17 August 2016
rolipram
has use
enzyme inhibitor
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
5260
language of work or name
English
retrieved
17 August 2016
dyphylline
object of statement has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1752
crisaborole
object of statement has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL484785
ibudilast
object of statement has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL19449
tetomilast
object of statement has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL332750
flavoxate hydrochloride
object of statement has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1200875
has part(s)
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q08493
HD/PDEase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q08493
3'5'-cyclic nucleotide phosphodiesterase, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q08493
Identifiers
RefSeq protein ID
NP_000914
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
NP_001092288
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
NP_001092289
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
NP_001317101
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
XP_011526358
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
XP_011526360
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
XP_024307303
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
NP_001356630
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5143
UniProt protein ID
Q08493
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q08493
Ensembl protein ID
ENSP00000262805
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000262805
ENSP00000402091
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000402091
ENSP00000469696
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000469696
ENSP00000470210
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000470210
ENSP00000439470
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000439470
ENSP00000472034
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000472034
ENSP00000473713
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000473713
ENSP00000473937
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000473937
ENSP00000474591
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000474591
ENSP00000474849
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000474849
ENSP00000476961
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000476961
PDB structure ID
2QYM
1 reference
stated in
UniProt
UniProt protein ID
Q08493
retrieved
9 August 2016
language of work or name
English
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(0 entries)
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(0 entries)
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(0 entries)
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Multilingual sites
(0 entries)
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Phosphodiesterase 4C
(Q21202200)
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