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Glutamate ionotropic receptor NMDA type subunit 1
(Q21118862)
Item
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From Wikidata
mammalian protein found in Homo sapiens
glutamate [NMDA] receptor subunit zeta-1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor ionotropic, NMDA 1
N-methyl-D-aspartate receptor channel, subunit zeta-1
NMD-R1
N-methyl-D-aspartate receptor subunit NR1
GRIN1
edit
Language
Label
Description
Also known as
default for all languages
No label defined
–
English
Glutamate ionotropic receptor NMDA type subunit 1
mammalian protein found in Homo sapiens
glutamate [NMDA] receptor subunit zeta-1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor ionotropic, NMDA 1
N-methyl-D-aspartate receptor channel, subunit zeta-1
NMD-R1
N-methyl-D-aspartate receptor subunit NR1
GRIN1
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q05586
subclass of
NMDA receptor
0 references
part of
Periplasmic binding protein-like I
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
ionotropic glutamate receptor, metazoa
2 references
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
Transporter Classification Database ID
1.A.10.1.20
retrieved
2 October 2019
based on heuristic
hierarchical database ID heuristic
Calmodulin-binding domain C0, NMDA receptor, NR1 subunit, protein family
1 reference
based on heuristic
inferred from protein domain or family
Receptor, ligand binding region, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ionotropic glutamate receptor domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q05586
encoded by
GRIN1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q05586
molecular function
calcium ion binding
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
signaling receptor binding
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
glycine binding
determination method or standard
IDA
IEA
IMP
4 references
retrieved
8 April 2019
stated in
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
calmodulin binding
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
protein binding
determination method or standard
IPI
2 references
retrieved
8 April 2019
stated in
Analysis of NR3A receptor subunits in human native NMDA receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IPI
retrieved
8 April 2019
stated in
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IPI
cation channel activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
extracellularly glutamate-gated ion channel activity
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
glutamate binding
determination method or standard
IDA
1 reference
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
calcium channel activity
determination method or standard
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
NMDA glutamate receptor activity
determination method or standard
IDA
IEA
3 references
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
retrieved
14 February 2017
stated in
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IDA
retrieved
14 February 2017
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IDA
ion channel activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ionotropic glutamate receptor activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
neurotransmitter binding
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
amyloid-beta binding
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
NMDA glutamate receptor activity
determination method or standard
IBA
IDA
IEA
IMP
ISS
TAS
9 references
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IBA
glutamate-gated calcium ion channel activity
determination method or standard
IDA
1 reference
retrieved
8 April 2019
stated in
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
signaling receptor activity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
protein-containing complex binding
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
cell component
cytoplasm
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
postsynaptic membrane
determination method or standard
ISS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
membrane
determination method or standard
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
synapse
determination method or standard
ISS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
NMDA selective glutamate receptor complex
determination method or standard
IDA
IEA
4 references
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
retrieved
14 February 2017
stated in
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IDA
retrieved
14 February 2017
stated in
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IDA
retrieved
14 February 2017
stated in
Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IDA
neuron projection
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
synaptic vesicle
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
dendritic spine
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cell surface
determination method or standard
ISS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
endoplasmic reticulum
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
integral component of membrane
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
plasma membrane
determination method or standard
TAS
IEA
2 references
retrieved
14 February 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
TAS
retrieved
14 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
postsynaptic density
determination method or standard
ISS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
integral component of plasma membrane
determination method or standard
IDA
4 references
retrieved
8 April 2019
stated in
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
excitatory synapse
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
cell junction
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
dendrite
determination method or standard
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
NMDA spikes in basal dendrites of cortical pyramidal neurons
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
synaptic cleft
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
terminal bouton
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
postsynaptic density membrane
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cytoplasm
determination method or standard
IEA
ISS
2 references
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
plasma membrane
determination method or standard
IBA
IDA
IEA
TAS
4 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IBA
NMDA selective glutamate receptor complex
determination method or standard
IBA
IDA
IEA
TAS
9 references
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IBA
synaptic membrane
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
glutamatergic synapse
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
integral component of postsynaptic density membrane
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
biological process
negative regulation of neuron apoptotic process
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
pons maturation
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
synaptic transmission, glutamatergic
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of respiratory gaseous exchange
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
response to amphetamine
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of membrane potential
determination method or standard
IDA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
retrieved
8 April 2019
stated in
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
regulation of synapse assembly
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
learning
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
positive regulation of excitatory postsynaptic potential
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
response to ethanol
determination method or standard
IDA
1 reference
retrieved
8 April 2019
stated in
Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
calcium ion transport
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
suckling behavior
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
prepulse inhibition
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
male mating behavior
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of long-term neuronal synaptic plasticity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
adult locomotory behavior
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of neuron apoptotic process
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ion transport
determination method or standard
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
memory
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of axonogenesis
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
neuromuscular process
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ionotropic glutamate receptor signaling pathway
determination method or standard
ISS
IEA
2 references
retrieved
14 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
ISS
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
excitatory postsynaptic potential
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
learning or memory
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
social behavior
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of neuronal synaptic plasticity
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
associative learning
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
startle response
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
calcium ion homeostasis
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cation transport
determination method or standard
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
cellular calcium ion homeostasis
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cation transmembrane transport
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
respiratory gaseous exchange by respiratory system
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of synaptic plasticity
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
response to morphine
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
propylene metabolic process
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
conditioned taste aversion
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cerebral cortex development
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
transport
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
sensory perception of pain
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
olfactory learning
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of cell communication
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
visual learning
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ephrin receptor signaling pathway
determination method or standard
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
MAPK cascade
determination method or standard
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
regulation of dendrite morphogenesis
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ion transmembrane transport
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
long-term memory
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
positive regulation of apoptotic process
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
positive regulation of transcription by RNA polymerase II
determination method or standard
ISS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
positive regulation of GTPase activity
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
calcium ion transmembrane transport
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
regulation of ion transmembrane transport
determination method or standard
IEA
1 reference
retrieved
14 February 2017
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586
determination method or standard
IEA
brain development
determination method or standard
NAS
1 reference
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
NAS
positive regulation of calcium ion transport into cytosol
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
calcium-mediated signaling
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
ionotropic glutamate receptor signaling pathway
determination method or standard
IEA
IMP
ISS
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
retrieved
8 April 2019
stated in
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
regulation of synaptic plasticity
determination method or standard
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
protein heterotetramerization
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
calcium ion transmembrane import into cytosol
determination method or standard
IDA
1 reference
retrieved
8 April 2019
stated in
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
excitatory chemical synaptic transmission
determination method or standard
NAS
1 reference
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
NAS
positive regulation of reactive oxygen species biosynthetic process
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
protein localization to postsynaptic membrane
determination method or standard
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IEA
cellular response to amyloid-beta
determination method or standard
IGI
1 reference
retrieved
8 April 2019
stated in
A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IGI
response to glycine
determination method or standard
IDA
1 reference
retrieved
8 April 2019
stated in
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
GOA
curator
UniProt
UniProt protein ID
Q05586
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
IDA
positive regulation of cysteine-type endopeptidase activity
determination method or standard
ISS
1 reference
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
ISS
regulation of NMDA receptor activity
determination method or standard
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586
determination method or standard
TAS
physically interacts with
glycine
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
727
language of work or name
English
retrieved
17 August 2016
L-aspartic acid
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
3309
language of work or name
English
retrieved
17 August 2016
Tetrazolylglycine
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
4068
language of work or name
English
retrieved
17 August 2016
N-methyl-D-aspartic acid
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
4268
language of work or name
English
retrieved
17 August 2016
homoquinolinic acid
has use
agonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
4216
language of work or name
English
retrieved
17 August 2016
5,7-dichlorokynurenic acid
has use
antagonist
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
2361
language of work or name
English
retrieved
17 August 2016
lanicemine
object of statement has role
channel blocker
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL467084
CERC-301
object of statement has role
antagonist
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL2068839
neboglamine
object of statement has role
positive allosteric modullator
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1255840
priralfinamide
object of statement has role
antagonist
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL2107771
esketamine
object of statement has role
negative allosteric modulator
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL395091
(RS)-ketamine
object of statement has role
negative allosteric modulator
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL742
cns-5161
object of statement has role
channel blocker
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL41306
(RS)-ketamine hydrochloride
object of statement has role
negative allosteric modulator
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1714
amantadine hydrochloride
object of statement has role
antagonist
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1569
orphenadrine citrate
object of statement has role
antagonist
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL1200395
has part(s)
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
Receptor, ligand binding region
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
Ionotropic glutamate receptor domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q05586
Identifiers
RefSeq protein ID
NP_000823
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
NP_001172019
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
NP_001172020
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
NP_015566
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
NP_067544
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
XP_005266128
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
XP_005266129
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
XP_005266130
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
XP_011516885
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2902
UniProt protein ID
Q05586
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q05586
Ensembl protein ID
ENSP00000360601
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360601
ENSP00000360605
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360605
ENSP00000360608
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360608
ENSP00000360614
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360614
ENSP00000360615
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360615
ENSP00000360616
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360616
ENSP00000316915
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000316915
ENSP00000360610
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000360610
PDB structure ID
2HQW
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
2NR1
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
3BYA
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5H8N
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5H8H
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5H8Q
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5H8F
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5I2N
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5I2K
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5KCJ
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
5KDT
1 reference
stated in
UniProt
UniProt protein ID
Q05586
retrieved
9 August 2016
language of work or name
English
Transporter Classification Database ID
1.A.10.1.20
2 references
stated in
Transporter Classification database
retrieved
13 March 2020
stated in
Transporter Classification database
retrieved
29 April 2020
Sitelinks
Wikipedia
(0 entries)
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Wikibooks
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
(0 entries)
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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Retrieved from "
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Glutamate ionotropic receptor NMDA type subunit 1
(Q21118862)
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