
OECD-validated tissue models contribute to the safety of cosmetics and pharmaceuticals
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The incubator and bioreactor systems developed at TLC-RT have a modular structure and can be adjusted to a wide variety of culture conditions.
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The TLC-RT develops synthetic as well as bio-logically based materials, e. g. (μ- and nano-) particles, fibers, coatings for regenerative medicine, tissue engineering and diagnostics. One of the core tasks is to cover the entire value chain, starting from R&D-tasks over process up-scaling, pre-clinic evaluation to the clinical phases.
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The production of novel drugs and medical devices is subject to high quality requirements. By fulfilling current regulatory guidelines, the TLC-RT ensures the highest level of patient safety for these new, innovative therapies.
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3D tissue models includes model systems of healthy and diseased organs to study pathogenic mechanisms and to test and evaluate new drugs. Picture shows a full skin model.
more info© Fraunhofer ISC / freepik
Incollaboration with WALA, the Translational Center at Fraunhofer ISC is developing anovel conjunctival model that enables theprecise analysis of inflammatory processes on the surface of the eye. Robust and scalable test systems allow active ingredients and complex drugs to be investigated under controlled but application-relevant conditions.
Are you working on similar topics? We would be happy to support you!
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Our innovative, patented 3D fibrous polyamide membrane forstromal in vitro tissue models offers a biomimetic structure with high porosity and bioactivity. It supports cell migration and the synthesis of human tissue.
Thisversatile solution is suitable formodels such as skin, small intestine andcolon andenables animal-free research.
© unsplash
Silicic acids, which are found in rice and bamboo, are important for our lives because they have a biostimulating effect on the body and the environment. At Fraunhofer ISC,sustainable, biodegradable materials are being developed from silicic acid that accelerate the body's regeneration and promote health. Dr. Bastian Christ will be glad to tell you more about the sustainable synthesis of biodegradable materials for life science applications!
© Fraunhofer ISC
The Fraunhofer Translation Center for Regenerative Therapies (TLC-RT) is taking overepiCS® technology from Henkel AG & Co. KGaA, ensuring the availability of internationally standardized epidermis models. TheseOECD-validated tissue models offer a reliable alternative for evaluating skin reactions to chemical substances and contribute to the safety of cosmetics and pharmaceuticals.
© freepik
Article SOFW Journal /29.1.2025
The ISC biomaterial team is generating abioresorbable RENACER® material platform for anovel vegan, biodegradable hair fixative from IPPM Technologies GmbH.
Together with its research partner Kneipp, the TLC-RT team is investigatingprotective as well as regenerative effects of various plant oils onin vitro skin models developed in-house. Thesescreenings can be carried outquickly, flexibly andwithout animal testing.
© K. Dobberke for Fraunhofer ISC
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Director of TLC-RT
Fraunhofer Translational Center Regenerative Therapies TLC-RT
Röntgenring 12
97070 Würzburg, Germany
Phone + 49 931 4100-136

Deputy Director of TLC-RT / Head of Biomaterials
Fraunhofer Translational Center Regenerative Therapies TLC-RT
Neunerplatz 2
97082 Würzburg, Germany
Phone +49 931 4100-516