General
Preferred name
NEBIVOLOL
Synonyms
NEBIVOLOL HYDROCHLORIDE()
Nebivolol HCl()
RO67555()
R-067555()
Bystolic()
R067555()
Hypoloc()
R65,824()
R-65824()
Narbivolol()
Nebilet()
(?)-Nebivolol-d4 (hydrochloride)()
P&D ID
PD009358
CAS
118457-14-0
104365-59-5
99200-09-6
2701283-32-9
Tags
available
biased GPCR ligand
drug
Approved by
FDA
First approval
2007
Drug indication
Antihypertensive (beta-blocker)
Hypertension
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nebivolol is a β-blocker, selective for β1-adrenoceptors.
Marketed formulations may contain nebivolol hydrochloride (PubChem CID ). (GtoPdb)
Marketed formulations may contain nebivolol hydrochloride (PubChem CID ). (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
BiasDB
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
405.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
2.36
TPSA
70.95
Fraction CSP3
0.45
Chiral centers
4.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antihypertensive Agents
VGSC Target
Nav1.5
Source data
