Oncotarget
Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.The term was introduced in the inaugural Editorial,Introducing Oncotarget.
As of January 1, 2022,Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.
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Impact Journals, LLC is the publisher of Oncotarget:www.impactjournals.com.
Impact Journals is a member of theWellcome Trust List of Compliant Publishers.
Impact Journals is a member of theSociety for Scholarly Publishing.
On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control.This malicious action will be reported to the FBI.
Dr. Samuel Silva from the Department of Pathology at Federal University of Ceará in Fortaleza, Brazil
Correspondence to -Fabio Tavora, email:[email protected]
Keywords:cancer, DLL3, pathology, biomarkers, qupath, small cell carcinoma
Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe from SUNY Upstate Medical University
Correspondence to -Mehdi Mollapour, email:[email protected]
Keywords:cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome
Dr. Benoit Chabot from Université de Sherbrooke in Quebec, Canada
Correspondence to -Benoit Chabot, email:[email protected]
Keywords:cancer, CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis
Dr. Georg F. Weber, from the University of Cincinnati Academic Health Center, James L. Winkle College of Pharmacy
Correspondence to -Georg F. Weber, email:[email protected]
Keywords:cancer, metastasis, metabolism, anchorage independence, mitochondrial mass, peroxide
Interview with Dr. Omkar Desai from the Department of Surgery at Case Western Reserve University and University Hospitals Cleveland Medical Center
Correspondence to -Rui Wang, email:[email protected]
Keywords:HER3, colorectal, pancreatic cancer, metastasis, microenvironment
Dr. Mangesh A. Thorat from Guy’s Hospital in London, Queen Mary University of London, and King’s College London, UK
Correspondence to -Mangesh A. Thorat, email:[email protected]
Keywords:cancer, ductal carcinoma in situ (DCIS), invasive breast cancer, ER, recurrence, clonality
Interview with Dr. Gopal C. Kundu from KIIT Deemed to be University in Odisha, India
Correspondence to -Gopal C. Kundu, email:[email protected]
Keywords:CAFs, heterogeneity, myofibroblasts, drug resistance, osteopontin
Interview with Dr. Georg F. Weber from the University of Cincinnati Academic Health Center, Cincinnati, OH, USA
Correspondence to -Georg F. Weber, email:[email protected]
Keywords:breast cancer premalignant lesion, biomarker, biopsy, mammography
Interview with Dr. Kerri Winters-Stone and Dr. Jacob Raber from Oregon Health and Science University, Portland, OR
Correspondence to -Jacob Raber , email:[email protected]
Keywords:apoE, breast cancer, exercise intervention, fall rate, functional status
Interview with Dr. Balraj Singh from the Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center
Keywords:resistant TNBC, minimal residual disease, intratumor heterogeneity, breast cancer relapse, metastasis prevention
Interview with Dr. Glenn Simmons Jr. from Cornell University College of Veterinary Medicine, and Dr. Stefani Thomas from University of Minnesota School of Medicine
Correspondence to -Glenn E. Simmons Jr., email:[email protected]
Keywords:ovarian cancer, lipid metabolism, biomarkers, microenvironment, fatty acid
Interview with Dr. Robert Hsu from the Department of Internal Medicine, Division of Medical Oncology, Norris Comprehensive Cancer Center and Hospital, University of Southern California
Correspondence to -Jorge J. Nieva, email:[email protected]
Keywords:lung cancer, tumor microenvironment, diagnostic biomarkers, biomarkers for immunotherapy, cancer testis antigen
Interview with Dr. Alexander Pohlman from Rush University Medical Center, Chicago, IL
Correspondence to -Jeffrey A. Borgia, email:[email protected]
Keywords:IGF, lung cancer, biomarkers, screening, prognostication
Interview with Franco Cortese from the Biogerontology Research Foundation, London, UK
Correspondence to -Ivan V. Ozerov, email:[email protected], Morten Scheibye-Knudsen, email:[email protected], and Alex Zhavoronkov, email:[email protected]
Keywords:radioresistance, space exploration, longevity, DNA damage, Mars mission
Interview with Dr. Dae Joon Kim and Liza Morales from the Department of Biomedical Sciences, School of Medicine, University of Texas Rio Grande Valley
Correspondence to -Dae Joon Kim, email:[email protected]
Keywords:TC-PTP, nuclear translocation, AKT, 14-3-3α, keratinocytes
Interview with Dr. Bishal Gyawali from the Institute of Cancer Policy, London and Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital
Correspondence to -Bishal Gyawali, email:[email protected]
Keywords:value, affordability, global oncology, drug prices, cancer
Interview with Dr. Derrick Haslem and Dr. Lincoln Nadauld from the Precision Genomics Program, Intermountain Healthcare, Saint George, UT
Correspondence to -Lincoln D. Nadauld, email:[email protected]
Keywords:precision medicine, oncology, outcomes, costs, overall survival
Interview with Dr. Nerymar Ortiz-Otero from the Meinig School of Biomedical Engineering, Cornell University
Correspondence to -Michael R. King, email:[email protected]
Keywords:metastasis, cancer associated fibroblasts, circulating tumor cells, cytoprotection, collective migration
Interview with Dr. Sandip Pravin Patel, Dr. Karen Yun and Dr. Karen Mccowen from the University of California San Diego
Correspondence to -Sandip Pravin Patel, email:[email protected]
Keywords:type 1 diabetes, diabetic ketoacidosis (DKA), immune-related adverse event (irAE), immunotherapy, PD-1 inhibitors
Interview with Dr. Sridhar Mani from Medicine and Genetics of the Albert Einstein College of Medicine
Correspondence to -Sridhar Mani, email:[email protected]
Keywords:microbial metabolites, inflammation, IBD, mimicry, drugs
Interview with Dr. J. Kimble Frazer and Dr. Gilseung Park from University of Oklahoma Health Sciences Center and Clay Foster from the University of North Carolina
Correspondence to -J. Kimble Frazer, email:[email protected]
Keywords:acute lymphoblastic leukemia, ALL, zebrafish, lymphocyte, MYC
Interview with Dr. Mobin Karimi from SUNY Upstate Medical University
Correspondence to -Mobin Karimi, email:[email protected]
Keywords:graft-versus-host disease, CrkL, T cell, migration, inflammation
Interview with Dr. Jennifer Sheng from Johns Hopkins Cancer Center
Correspondence to -Jennifer Y. Sheng, email:[email protected]
Keywords:breast cancer, obesity, lifestyle interventions
Interview with Dr. Gina Abdelaal and Dr. Stephany Veuger from Northumbria University
Correspondence to -Gina Abdelaal, email:[email protected]
Keywords:iron chelator, oncogenesis, selective cytotoxicity, hallmarks of cancer, NDRG1
Interview with Dr. Sivanesan Dakshanamurthy from Georgetown University Medical Center and Dr. Qiyi Tang and Dr. Hemayet Ullah from Howard University College of Medicine
Keywords:host targeted antiviral (HTA), herpes simplex virus (HSV), receptor for activated C kinase 1 (RACK1), RACK1 inhibitor, internal ribosomal entry site (IRES)
Interview with Dr. Jean-François Laes from OncoDNA SA
Correspondence to -Jean-François, email:[email protected]
Keywords:molecular profiling, solid tumour, precision medicine, next-generation sequencing, therapeutic decision making in oncology
Interview with Dr. Michael H. Roehrl from Memorial Sloan Kettering Cancer Center
Correspondence to -Michael H. Roehrl , email:[email protected]
Keywords:P4HA1, colorectal cancer, biomarker, prognosis, pathology
Interview with Brian A. Van Tine and Dr. Charles Schutt from the Division of Medical Oncology, Washington University
Correspondence to -Brian A. Van Tine, email:[email protected]
Keywords:head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration
Interview with Dr. Katherine M. Bever from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Correspondence to -Dung T. Le, email:[email protected]
Keywords:pancreatic cancer, mTOR inhibition, maintenance therapy, metformin
Interview with Susan E. Erdman from Massachusetts Institute of Technology
Correspondence to -Susan E. Erdman, email:[email protected]
Keywords:body weight, mouse, exotoxin subunit B, CLS, inflammation
Interview with Dr. Richard C. Schwartz from Michigan State University
Correspondence to -Richard C. Schwartz, email:[email protected]
Keywords:oxybenzone, benzophenone-3, mammary tumorigenesis, dietary animal fat, breast cancer
Interview with Dr. Yves C. Chabu from the Division of Biological Sciences, University of Missouri
Correspondence to -Yves C. Chabu, email:[email protected]
Keywords:salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP
Interview with Dr. Tapasree Roy Sarkar from the Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center and the Department of Biology, Texas A&M University
Correspondence to -Tapasree Roy Sarkar, email:[email protected]
Keywords:angiogenesis, endothelial transdifferentiation, epithelial-mesenchymal transition, vasculogenic mimicry, FOXC2
Interview with Dr. Wafik S. El-Deiry from the Cancer Center at Brown University and Warren Alpert Medical School, and Marie D. Ralff from Temple University
Correspondence to -Wafik S. El-Deiry, email:[email protected]
Keywords:ONC201, TRAIL, breast cancer, death receptors, apoptosis
Interview with Dr. Vladimir N. Anisimov from the N.N. Petrov National Medical Research Center of Oncology
Correspondence to -Vladimir N. Anisimov, email:[email protected]
Keywords:prostate cancer, overall survival, poor prognosis, melatonin
Interview with Dr. Hua Li and Dr. Shashwat Sharad from Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical and Center and Henry Jackson Foundation for the Advancement of Military Medicine
Correspondence to -Hua Li, email:[email protected] and Shashwat Sharad, email:[email protected]
Keywords:prostate cancer, PMEPA1, gene isoform, splice variant, TGF-β
Interview with Dr. Beatrice Aramini and Dr. Valentina Masciale from the Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia
Correspondence to -Beatrice Aramini, email:[email protected]
Keywords:cancer stem cells, macrophages, future perspectives, cancer, target treatments
Interview with Dr. Benjamin Purow from the Department of Neurology, University of Virginia
Correspondence to -Benjamin Purow, email:[email protected]
Keywords:statin, glioblastoma, TGF-beta, SMAD3, RhoA/ROCK
Interview with Dr. Bruce M. Boman from the University of Delaware, Helen F. Graham Cancer Center and Research Institute, and Thomas Jefferson University
Correspondence to -Bruce M. Boman, email:[email protected]
Keywords:ALDH, retinoic acid, colorectal cancer, stem cell, neuroendocrine cell
Interview with Dr. Lawrence M. Pfeffer and Dr. Debolina Ganguly from the Department of Pathology and Laboratory Medicine, and Center for Cancer Research, University of Tennessee Health Science Center
Correspondence to -Lawrence M. Pfeffer, email:[email protected]
Keywords:STAT3, glioblastoma, phosphorylation, gene expression, tumorigenesis
Interview with Dr. Mariana Perepitchka, Dr. Yekaterina Galat, and Dr. Vasiliy Galat
Correspondence to -Mariana Perepitchka, email:[email protected], Yekaterina Galat, email:[email protected], and Vasiliy Galat, email:[email protected]
Keywords:down syndrome, iPSC-derived endothelial model, T21 genome-wide Implications, meta-analysis, tumor microenvironment
Interview with Dr. Beatrice Aramini from the University of Modena and Reggio Emilia
Correspondence to -Beatrice Aramini, email:[email protected]
Keywords:immunophenotype, cancer stem cells, cancer stem-like cells, non-small cell lung cancer (NSCLC), target therapy
Interview with Dr. Kelber from the Department of Biology, at the California State University Northridge
Correspondence to -Jonathan A. Kelber, email:[email protected]
Keywords:premetastatic niche, tumor microenvironment, metastasis, breast cancer secretomes, LCN2
Interview with the National Institutes of Health's Dr. Stanley Lipkowitz & Dr. Yoshimi Endo Greer
Correspondence to -Stanley Lipkowitz, email:[email protected]
Keywords:ONC201, breast cancer, mitochondria
Interview with Dr. Arieh Eden from Lady Davis Carmel Medical Center
Correspondence to -Arieh Eden, email:[email protected]
Keywords:sepsis, empty SV40 capsids, RNAseq, signaling, cellular functions
Interview with Dr. Beatrice Aramini from the University of Modena University of Modena and Reggio Emilia
Correspondence to -Beatrice Aramini, email:[email protected]
Keywords:somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy
Interview with Dr. Mary J. Janatpour from Dynavax Technologies
Correspondence to -Mary J. Janatpour, email:[email protected]
Keywords:TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity
Interview with Prof. Malka Cohen-Armon from Tel Aviv University
Correspondence to -Malka Cohen-Armon, email:[email protected]
Keywords:PJ34, pancreas cancer, stroma, PANC1 cancer xenografts
Interview with Dr. Marie Wood from the University of Vermont Cancer Center
Correspondence to -Nicholas H. Farina, email:[email protected]
Marie E. Wood, email:[email protected]
Keywords:microRNA; high risk breast cancer; liquid biopsy; risk signature; benign breast disease
Interview with Dr. Sameek Roychowdhury & Dr. Hui Zi Chen from Ohio State University
Correspondence to -Sameek Roychowdhury, email:[email protected]
Keywords:tumor heterogeneity, research autopsy, hypermutation
Interview with Professor Mohamed El-Tanani from the University of Bradford
Correspondence to -Mohamed El-Tanan, email:[email protected]
Keywords:pimozide, breast cancer, DSB, apoptosis, xenograft
Interview with Dr. Tanwar from the University of Newcastle
Correspondence to -Pradeep S. Tanwar, email:[email protected]
Keywords:Wnt, βcatenin, spermatgonia, testicular cancer, fertility, Gerotarget
Interview with Dr. Anutosh Ganguly from the University of Texas Medical School
Correspondence to -Fernando Cabral, email:[email protected]
Keywords:tubulin isotypes; microtubules; dynamic instability; motility; drug resistance
Interview with Dr. Francisco Esteva from Perlmutter Cancer Center
Correspondence to -Francisco J. Esteva, email:[email protected]
Aristotelis Tsirigos, email:[email protected]
Keywords:breast cancer; gene expression profiling
Interview with Dr. Gregory J. Riggins from Johns Hopkins University
Correspondence to -Gregory J. Riggins, email:[email protected]
Paul J. Hergenrother, email:[email protected]
Timothy M. Fan, email:[email protected]
Keywords:PAC-1, procaspase-3 activator, glioblastoma, small molecule therapy
Interview with Dr. Marene Landström & Dr. Reshma Sundar from Umeå University
Correspondence to -Marene Landström, email:[email protected]
Keywords:signal transduction, tumor biology, Snail1, sumoylation, prostate cancer
Interview with Dr. John R. Hawse from Mayo Clinic
Correspondence to -John R. Hawse, email:[email protected]
Keywords:TNBC, ERβ, cell cycle, CDK, estrogen
Interview with Dr. Gary Goldberg from Rowan University
Correspondence to -Gary S. Goldberg, email:[email protected]
Keywords:podoplanin, cancer, cell migration, receptor, lectin
Interview with Dr. Neil from the University of Glasgow
Correspondence to -James C. Neil, email:[email protected]
Ewan Cameron, email:[email protected]
Keywords:Runx1, lymphoma, myc, oncogene addiction
Interview with Dr. Carmelo Nucera from Harvard Medical School
Correspondence to -Carmelo Nucera, email:[email protected]
Keywords:papillary thyroid cancer preclinical model, BRAFV600E, chromosome 5, combined therapy with vemurafenib and palbociclib, drug resistance
Interview with Dr. Whitney Henry from Harvard Medical School
Correspondence to -Alex Toker, email:[email protected]
John L. Rinn, email:[email protected]
Keywords:lncRNA, Src, PI3K, breast cancer, LINC00520
Interview with Dr. Field from the University of Miami
Correspondence to -J. William Harbour, email:[email protected]
Keywords:PRAME, preferentially expressed antigen in melanoma, uveal melanoma, DNA methylation, chromosomal instability
Interview with Dr. Dmitrovsky from the Geisel School of Medicine and the University of Texas
Correspondence to -Ethan Dmitrovsky, email:[email protected]
Keywords:ISG15, USP18, PTEN, protein stability, and lung cancer
Interview with Dr. Kelber from California State University Northridge
Correspondence to -Jonathan A. Kelber, email:[email protected]
Keywords:FFPE RNA extraction, microHomogenizer™, pancreatic cancer, patient-derived orthotopic xenografts (PDOX) tumor microenvironment, cancer biomarkers
Interview with Dr. Raz from Leiden University Medical Center
Correspondence to -Vered Raz, email:[email protected]
Keywords:shoulder disease, atrophy, fatty infiltration, muscle satellite cells, deep RNA-seq, Gerotarget
Interview with Dr. Hirbe from the Washington University School of Medicine
Correspondence to -David H. Gutmann, email:[email protected]
Keywords:Neurofibromatosis Type 1, MPNST, lentivirus, p53, mouse models
Interview with Dr. Larrivée from the University of Montreal
Correspondence to -Bruno Larrivée, email:[email protected]
Keywords:age-related macular degeneration, ocular pathologies, angiogenesis, BMP signaling, Gerotarget
Interview with Dr. Hechtman from Memorial Sloan Kettering Cancer Center
Correspondence to -Jaclyn F. Hechtman, email:[email protected]
Keywords:SOX9, colorectal carcinoma, KRAS, TP53, oncogene, Pathology Section
Interview with Dr. Chesler from the Institute of Cancer Research and the Royal Marsden NHS Trust
Correspondence to -Louis Chesler, email:[email protected]
Keywords:neuroblastoma, mTOR, MYC, MYCN, PI3-kinase
Interview with Dr. Schroeder from the University of Arizona
Correspondence to -Joyce Schroeder, email:[email protected]
Keywords:polarity, migration, Llgl1, epidermal growth factor receptor, TAZ
Interview with Dr. Bernards & Diede Brunen from the Netherlands Cancer Institute
Correspondence to -René Bernards, email:[email protected]
Keywords:AML, PIM, AZD1208, p38, resistance
Interview with Dr. Karpel-Massler & Dr. Siegelin from Columbia University Medical Center
Correspondence to -Markus D. Siegelin, email:[email protected]
Keywords:apoptosis, L-asparaginase, ABT263, TRAIL, glioblastoma
Interview with Dr. Ayyadevara & Dr. Shmookler Reis from the Central Arkansas Veterans Healthcare Service and the University of Arkansas
Correspondence to -Robert J. Shmookler Reis, email:[email protected]
Srinivas Ayyadevara, email:[email protected]
Keywords:phosphatidylinositol 3-kinase; phosphatidylinositol 3,4,5-triphosphate (PIP3); longevity; oxidative stress resistance; protein aggregation
Interview with Dr. Neelam and Sudeshna Goswami from the Chicago Medical School
Correspondence to -Neelam Sharma-Walia, email:[email protected]
Keywords:osteoprotegerin, NF-kB, COX-2, PGE2, FASN
Interview with Dr. Pastan from the National Cancer Institute
Correspondence to -Ira Pastan, email:[email protected]
Keywords:epitope, immunogenicity, rational design, mesothelioma, pancreatic cancer
Interview with Dr. Aaronson from the Icahn School of Medicine
Correspondence to -Stuart A. Aaronson, email:[email protected]
Keywords:tankyrase inhibitors, TEAD, YAP, angiomotin, tumor cell proliferation
Interview with Dr. Savaskan from the University Hospital Erlangen and BiMECON ENT.
Correspondence to -Nicolai E. Savaskan, email:[email protected],[email protected]
Keywords:glioma, PRG3, Ras, oncogenesis, neuronal plasticity
Interview with Dr. Felsher from Stanford University
Correspondence to -Dean W. Felsher, email:[email protected]
Keywords:apoptosis, BIM, targeted therapies, oncogene inactivation
Interview with Dr. Bohr from National Institute on Aging
Correspondence to -Vilhelm A. Bohr, email:[email protected]
Keywords:breast cancer, Werner syndrome, helicase, camptothecin, topoisomerase I
Interview with Dr. Loeb from Johns Hopkins University
Correspondence to -David M. Loeb, email:[email protected]
Keywords:sarcoma, metastasis, Wnt signaling, DKK-1, mouse model
Interview with Dr. Tanwar from the School of Biomedical Sciences and Pharmacy
Correspondence to -Pradeep S. Tanwar, email:[email protected]
Keywords:ovarian aging, rapamycin, mTOR, ovary, OSE, Gerotarget
Interview with Dr. Mancini & Dr. Toker from Harvard Medical School
Correspondence to -Alex Toker, email:[email protected]
Keywords:Akt, breast cancer, PI 3-kinase, HER2, estrogen receptor
Interview with Dr. Bratslavsky & Dr. Mollapour from SUNY Upstate Medical University
Correspondence to -Mehdi Mollapour, email:[email protected]
Gennady Bratslavsky, email:[email protected]
Keywords:FLCN, Birt-Hogg-Dubé syndrome, renal cell carcinoma, clear cell renal cell carcinoma
Interview with Dr. Slack from Harvard Medical School
Correspondence to -Frank J. Slack, email:[email protected]
Keywords:KRAS, 3′ UTR, post-transcriptional regulation, microRNAs (miRNAs), miR-185
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