Oncotarget
Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.The term was introduced in the inaugural Editorial,Introducing Oncotarget.
As of January 1, 2022,Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.
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| 10.18632/ONCOTARGET.23208 |
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| 10.18632/ONCOTARGET.9859 |
| 10.18632/ONCOTARGET.13553 |
| 10.18632/ONCOTARGET.14401 |
| 10.18632/ONCOTARGET.15422 |
| 10.18632/ONCOTARGET.16407 |
| 10.18632/ONCOTARGET.19087 |
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On August 25, 2022, the Office of Science and Technology Policy announced a new government policy legislating the immediate public release of all United States-funded research publications by 2025.Learn more here andhere.
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June 19, 2018
About The Cover
The cover for issue 47 of Oncotarget features Figure 6, "MR-409 down-regulates IGF-1 expression in cancer cells," byCui, et al.
Table of Contents
Letters to the Editor
| Maintenance ramucirumab monotherapy after intolerable toxicities following docetaxel plus ramucirumab |
https://doi.org/10.18632/oncotarget.25623 Akito Hata, and Nobuyuki Katakami |
| 28292-28293 |
| PDF | How to cite |
Research Papers: Immunology
| BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells |
https://doi.org/10.18632/oncotarget.25511 Eva Hajek,Franziska Krebs,Rebekka Bent,Katharina Haas,Antje Bast,Ivo Steinmetz,Andrea Tuettenberg,Stephan Grabbe, and Matthias Bros |
| 28294-28308 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |  |
Research Papers
| IL-23 enhances the malignant properties of hepatoma cells by attenuation of HNF4α |
https://doi.org/10.18632/oncotarget.24875 Qing Jiang,Yuanli Sun,Zilong Guo,Ru Chen,Simin Ma,Mingpeng Fu,Huifen Zhu,Qin Ning,Ping Lei, and Guanxin Shen |
| 28309-28321 |
| Abstract | PDF | HTML | How to cite |
| Proteomics identification and characterization of MbovP730 as a potential DIVA antigen ofMycoplasma bovis |
https://doi.org/10.18632/oncotarget.22265 Farhan Anwar Khan,Gang Zhao,Yusi Guo,Muhammad Faisal,Jin Chao,Xi Chen,Chenfei He,Harish Menghwar,Rahim Dad,Muhammad Zubair,Changmin Hu,Yingyu Chen,Huanchun Chen,Zhang Rui, and Aizhen Guo |
| 28322-28336 |
| Abstract | PDF | HTML | How to cite |
| The human blood DNA methylome identifies crucial role of β-catenin in the pathogenesis of Kawasaki disease |
https://doi.org/10.18632/oncotarget.25305 Kuang-Den Chen,Ying-Hsien Huang,Mindy Ming-Huey Guo,Tzu-Yang Lin,Wei-Teng Weng,Hsiang-Jen Yang,Kuender D. Yang, and Ho-Chang Kuo |
| 28337-28350 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Increased Nrf2 expression by renal cell carcinoma is associated with postoperative chronic kidney disease and an unfavorable prognosis |
https://doi.org/10.18632/oncotarget.25322 Hideo Yuki,Takao Kamai,Satoshi Murakami,Satoru Higashi,Takahiro Narimatsu,Tsunehito Kambara,Hironori Betsunoh,Hideyuki Abe,Kyoko Arai,Hiromichi Shirataki, and Ken-Ichiro Yoshida |
| 28351-28363 |
| Abstract | PDF | HTML | How to cite |
| Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment |
https://doi.org/10.18632/oncotarget.25342 Amandine Martin,Cédric Seignez,Cindy Racoeur,Nicolas Isambert,Nesrine Mabrouk,Alessandra Scagliarini,Sylvie Reveneau,Laurent Arnould,Ali Bettaieb,Jean-François Jeannin, and Catherine Paul |
| 28364-28378 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| MicroRNA analysis of gastroenteropancreatic neuroendocrine tumors and metastases |
https://doi.org/10.18632/oncotarget.25357 Nadine Zimmermann,Juliana Knief,Tim Kacprowski,Pamela Lazar-Karsten,Tobias Keck,Franck Billmann,Sebastian Schmid,Kim Luley,Hendrik Lehnert,Georg Brabant, and Christoph Thorns |
| 28379-28390 |
| Abstract | PDF | HTML | How to cite |
| MiR-199a-3p decreases esophageal cancer cell proliferation by targeting p21 activated kinase 4 |
https://doi.org/10.18632/oncotarget.25375 Pornima Phatak,Whitney M. Burrows,Ingrid E. Chesnick,Mohan E. Tulapurkar,Jaladanki N. Rao,Douglas J. Turner,Anne W. Hamburger,Jian-Ying Wang, and James M. Donahue |
| 28391-28407 |
| Abstract | PDF | HTML | How to cite |
| Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression |
https://doi.org/10.18632/oncotarget.25400 Naomi Nakayama,Gyosuke Sakashita,Yuko Nariai,Hiroaki Kato,Kaori Sinmyozu,Jun-Ichi Nakayama,Satoru Kyo,Takeshi Urano, and Kentaro Nakayama |
| 28408-28420 |
| Abstract | PDF | HTML | How to cite |
| Comparative molecular characterization of typical and exceptional responders in glioblastoma |
https://doi.org/10.18632/oncotarget.25420 Kristin Wipfler,Adam S. Cornish, and Chittibabu Guda |
| 28421-28433 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growthin vitro andin vivo |
https://doi.org/10.18632/oncotarget.25421 Shuhei Shinoda,Seiji Kaino,Shogo Amano,Hirofumi Harima,Toshihiko Matsumoto,Koichi Fujisawa,Taro Takami,Naoki Yamamoto,Takahiro Yamasaki, and Isao Sakaida |
| 28434-28444 |
| Abstract | PDF | HTML | How to cite |
| Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis |
https://doi.org/10.18632/oncotarget.25442 Chrissta X. Maracle,Kim C.M. Jeucken,Boy Helder,Thomas M. van Gulik,Anne Steins,Hanneke W.M. van Laarhoven, and Sander W. Tas |
| 28445-28455 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells |
https://doi.org/10.18632/oncotarget.25466 Vojtech Novohradsky,Juraj Zajac,Oldrich Vrana,Jana Kasparkova, and Viktor Brabec |
| 28456-28473 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib |
https://doi.org/10.18632/oncotarget.25494 Rocio I.R. Macias,Anabel Sánchez-Martín,Gabriela Rodríguez-Macías,Luis I. Sánchez-Abarca,Elisa Lozano,Elisa Herraez,Maria D. Odero,José L. Díez- Martín,Jose J.G. Marin, and Oscar Briz |
| 28474-28485 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma |
https://doi.org/10.18632/oncotarget.25503 Ekaterina A. Potter,Anastasia S. Proskurina,Genrikh S. Ritter,Evgenia V. Dolgova,Valeriy P. Nikolin,Nelly A. Popova,Oleg S. Taranov,Yaroslav R. Efremov,Sergey I. Bayborodin,Aleksandr A. Ostanin,Elena R. Chernykh,Nikolay A. Kolchanov, and Sergey S. Bogachev |
| 28486-28499 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells |
https://doi.org/10.18632/oncotarget.25526 Dana Koslawsky,Marianna Zaretsky,Ron Alcalay,Ohad Mazor,Amir Aharoni, and Niv Papo |
| 28500-28513 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells |
https://doi.org/10.18632/oncotarget.25530 Sony Pandey,Jennifer Bourn, and Maria Cekanova |
| 28514-28531 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Prostate cancer susceptibility geneHIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition |
https://doi.org/10.18632/oncotarget.25536 Kendra A. Williams,Minnkyong Lee,Jean M. Winter,Derek E. Gildea,Carla Calagua,Natasha L. Curry,Jens Lichtenberg,Huihui Ye, and Nigel P.S. Crawford |
| 28532-28546 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma |
https://doi.org/10.18632/oncotarget.25558 Aya Maeda,Yuki Nishida,Marla Weetall,Liangxian Cao,Arthur Branstrom,Jo Ishizawa,Takenobu Nii,Wendy D. Schober,Yoshiaki Abe,Kosei Matsue,Mariko Yoshimura,Shinya Kimura, and Kensuke Kojima |
| 28547-28560 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer |
https://doi.org/10.18632/oncotarget.25564 Karim Boudadi,Daniel L. Suzman,Valsamo Anagnostou,Wei Fu,Brandon Luber,Hao Wang,Noushin Niknafs,James R. White,John L. Silberstein,Rana Sullivan,Donna Dowling,Rana Harb,Thomas R. Nirschl,Brendan A. Veeneman,Scott A. Tomlins,Yipeng Wang,Adam Jendrisak,Ryon P. Graf,Ryan Dittamore,Michael A. Carducci,Mario A. Eisenberger,Michael C. Haffner,Alan K. Meeker,James R. Eshleman,Jun Luo,Victor E. Velculescu,Charles G. Drake, and Emmanuel S. Antonarakis |
| 28561-28571 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| 2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography, diffusion-weighted magnetic resonance imaging, and choline spectroscopy to predict the activity of cetuximab in tumor xenografts derived from patients with squamous cell carcinoma of the head and neck |
https://doi.org/10.18632/oncotarget.25574 Lionel Mignion,Sandra Schmitz,Nicolas Michoux,Xavier Caignet,Rose-Marie Goebbels,Anne Bol,Marie-Aline C. Neveu,Vincent Grégoire,Thierry Duprez,Renaud Lhommel,Fréderic Amant,Els Hermans,Benedicte F. Jordan, and Jean-Pascal Machiels |
| 28572-28585 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma |
https://doi.org/10.18632/oncotarget.25580 Joana N.R. Dias,Sandra I. Aguiar,Diane M. Pereira,Ana S. André,Lurdes Gano,João D.G. Correia,Belmira Carrapiço,Barbara Rütgen,Rui Malhó,Conceição Peleteiro,João Goncalves,Cecília M.P. Rodrigues,Solange Gil,Luís Tavares, and Frederico Aires-da-Silva |
| 28586-28598 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells |
https://doi.org/10.18632/oncotarget.25583 Abdulkhaleg Ibrahim,Mahmoud Alhosin,Christophe Papin,Khalid Ouararhni,Ziad Omran,Mazin A. Zamzami,Abdulrahman Labeed Al-Malki,Hani Choudhry,Yves Mély,Ali Hamiche,Marc Mousli, and Christian Bronner |
| 28599-28611 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer |
https://doi.org/10.18632/oncotarget.25584 Laura Barrio-Real,Cynthia Lopez-Haber,Victoria Casado-Medrano,Alexander G. Goglia,Jared E. Toettcher,Maria J. Caloca, and Marcelo G. Kazanietz |
| 28612-28624 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| RIOK1 kinase activity is required for cell survival irrespective of MTAP status |
https://doi.org/10.18632/oncotarget.25586 Alexandra Hörmann,Barbara Hopfgartner,Thomas Köcher,Maja Corcokovic,Teresa Krammer,Christoph Reiser,Gerd Bader,Junwei Shi,Katharina Ehrenhöfer,Simon Wöhrle,Norbert Schweifer,Christopher R. Vakoc,Norbert Kraut,Mark Pearson,Mark Petronczki, and Ralph A. Neumüller |
| 28625-28637 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model |
https://doi.org/10.18632/oncotarget.25587 Kenichiro Seki,Mitsuteru Kitade,Norihisa Nishimura,Kosuke Kaji,Kiyoshi Asada,Tadashi Namisaki,Kei Moriya,Hideto Kawaratani,Yasushi Okura,Hiroaki Takaya,Yasuhiko Sawada,Shinya Sato,Keisuke Nakanishi, and Hitoshi Yoshiji |
| 28638-28651 |
| Abstract | PDF | HTML | How to cite |
| Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry |
https://doi.org/10.18632/oncotarget.25595 Maria-Magdalena Georgescu,Adriana Olar,Bret C. Mobley,Phyllis L. Faust, and Jack M. Raisanen |
| 28652-28665 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance |
https://doi.org/10.18632/oncotarget.25596 Aysegül Kaymak,Sergi Sayols,Thaleia Papadopoulu, and Holger Richly |
| 28666-28690 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Advantage ofHSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients |
https://doi.org/10.18632/oncotarget.25611 Gustavo Noriz Berardinelli,Cristovam Scapulatempo-Neto,Ronílson Durães,Marco Antônio de Oliveira,Denise Guimarães, and Rui Manuel Reis |
| 28691-28701 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus |
https://doi.org/10.18632/oncotarget.25614 Anton Oseledchyk,Jacob M. Ricca,Mathieu Gigoux,Brian Ko,Gil Redelman-Sidi,Tyler Walther,Cailian Liu,Gopa Iyer,Taha Merghoub,Jedd D. Wolchok, and Dmitriy Zamarin |
| 28702-28716 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids |
https://doi.org/10.18632/oncotarget.25617 Samaneh K. Sarvestani,Steven A. Signs,Veronique Lefebvre,Stephen Mack,Ying Ni,Andrew Morton,Ernest R. Chan,Xiaoxia Li,Paul Fox,Angela Ting,Matthew F. Kalady,Michael Cruise,Jean Ashburn,Jennifer Stiene,Wei Lai,David Liska,Shao Xiang, and Emina H. Huang |
| 28717-28730 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer |
https://doi.org/10.18632/oncotarget.25618 Alfiah Noor,Ijeoma Adaku Umelo,Peter Kronenberger,Philippe Giron,Elly De Vlieghere,Olivier De Wever,Erik Teugels, and Jacques De Grève |
| 28731-28744 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Growth hormone-releasing hormone (GHRH) and its agonists inhibit hepatic and tumoral secretion of IGF-1 |
https://doi.org/10.18632/oncotarget.25676 Tengjiao Cui, and Andrew V. Schally |
| 28745-28756 |
| Abstract | PDF | HTML | Supplementary Information | How to cite | Press Release |
Clinical Research Papers
| Trends and outcomes of women with synchronous endometrial and ovarian cancer |
https://doi.org/10.18632/oncotarget.25550 Koji Matsuo,Hiroko Machida,Erin A. Blake,Laura L. Holman,Bobbie J. Rimel,Lynda D. Roman, and Jason D. Wright |
| 28757-28771 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients |
https://doi.org/10.18632/oncotarget.25594 Sebastian Regnery,Sebastian Adeberg,Constantin Dreher,Johanna Oberhollenzer,Jan-Eric Meissner,Steffen Goerke,Johannes Windschuh,Katerina Deike-Hofmann,Sebastian Bickelhaupt,Moritz Zaiss,Alexander Radbruch,Martin Bendszus,Wolfgang Wick,Andreas Unterberg,Stefan Rieken,Jürgen Debus,Peter Bachert,Mark Ladd,Heinz-Peter Schlemmer, and Daniel Paech |
| 28772-28783 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
| Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia |
https://doi.org/10.18632/oncotarget.25609 Ana Paula Trussardi Fayh,Camila de Carvalho Gomes,Helena Trevisan Schroeder,Carlos Henrique de Lemos Muller,Telma Maria de Araújo Moura Lemos, and Mauricio Krause |
| 28784-28795 |
| Abstract | PDF | HTML | How to cite |
Corrections
| Correction: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway |
https://doi.org/10.18632/oncotarget.25677 Bo Ram Kim,Yoon A. Jeong,Yoo Jin Na,Seong Hye Park,Min Jee Jo,Jung Lim Kim,Soyeon Jeong,Suk-Young Lee,Hong Jun Kim,Sang Cheul Oh, and Dae-Hee Lee |
| 28796-28796 |
| Correction | PDF | How to cite |
| Correction: Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment |
https://doi.org/10.18632/oncotarget.25683 Hajer Ziouziou,Claudia Andrieu,Erik Laurini,Sara Karaki,Maurizio Fermeglia,Ridha Oueslati,David Taieb,Michel Camplo,Olivier Siri,Sabrina Pricl,Maria Katsogiannou, and Palma Rocchi |
| 28797-28797 |
| Correction | PDF | How to cite |
| Correction: Combining molecular and immunohistochemical analyses of key drivers in primary melanomas: interplay between germline and somatic variations |
https://doi.org/10.18632/oncotarget.25684 William Bruno,Claudia Martinuzzi,Bruna Dalmasso,Virginia Andreotti,Lorenza Pastorino,Francesco Cabiddu,Marina Gualco,Francesco Spagnolo,Alberto Ballestrero,Paola Queirolo,Federica Grillo,Luca Mastracci, and Paola Ghiorzo |
| 28798-28798 |
| Correction | PDF | How to cite |
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