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Oncoscience

Oncoscience is a peer-reviewed, open-access journal dedicated to cancer research without financial barriers. It is a unique journal that provides FREE publication and access for both authors and readers. Oncoscience is indexed and archived by PubMed and PMC. It is recognized by Impact Journals as a philanthropic endeavor.

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About The Cover

γKlotho is a Novel Marker and Cell Survival Factor in a Subset of Triple Negative Breast Cancers. Cover art by J. Weon, See Trošt et al. 

Table of Contents

Click chemistry, 3D-printing, and omics: the future of drug development

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3

Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns

Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

EZH2 in normal hematopoiesis and hematological malignancies

MEF2 transcription factors: developmental regulators and emerging cancer genes

Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance?

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma

Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma

Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma

Disentangling the microRNA regulatorymilieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

Transcription factor LSF (TFCP2) inhibits melanoma growth

Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma

Prognostic impact of concurrentMYC andBCL6 rearrangements and expression inde novo diffuse large B-cell lymphoma

MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalitiesin vitro andin vivo

Transforming growth factor-β1 polymorphisms and graft-versus-host disease risk: a meta-analysis

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression

NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal

Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma

Tumor-associated fibroblast-conditioned medium induces CDDP resistance in HNSCC cells

LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer

Computational selection of antibody-drug conjugate targets for breast cancer

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells

Overexpression ofATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

Novel variants inMLL confer to bladder cancer recurrence identified by whole-exome sequencing

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma

MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1

miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma

STB-HO, a novel mica fine particle, inhibits the teratoma-forming ability of human embryonic stem cells after in vivo transplantation

Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation

microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10

TheBIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas

An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese

Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effectsin vitro andin vivo

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

Biocompatible and colloidally stabilized mPEG-PE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors

Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity

TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway

Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML)

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation

The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms

Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells

miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways

Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells

Mps1 is SUMO-modified during the cell cycle

Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer

Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells

Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression

A chemotherapy response classifier based on support vector machines for high-grade serous ovarian carcinoma

Direct quantitative detection for cell-free miR-155 in urine: a potential role in diagnosis and prognosis for non-muscle invasive bladder cancer

Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma

Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity

Unique roles ofAkt1 andAkt2 in IGF-IR mediated lung tumorigenesis

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Prognostic significance of FAM83D gene expression across human cancer types

Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions

EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment

Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3

Regulatory T cells may participate inHelicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells

Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop

Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer

HER2 genomic amplification in circulating tumor DNA from patients with cetuximab-resistant colorectal cancer

Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ

FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

Metronomic topotecan impedes tumor growth ofMYCN-amplified neuroblastoma cellsin vitro andin vivo by therapy induced senescence

A microRNA-based prediction model for lymph node metastasis in hepatocellular carcinoma

Mutually exclusive mutations inNOTCH1 andPIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China

Tolerability and efficacy of gamma knife radiosurgery on hepatocellular carcinoma with portal vein tumor thrombosis

HAG regimen improves survival in adult patients with hypocellular acute myeloid leukemia

Greater efficacy of chemotherapy plus bevacizumab compared to chemo- and targeted therapy alone on non-small cell lung cancer patients with brain metastasis

Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients’ survival