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ED-A is expressed both in primary tumors and metastases in the MMTV-PyMT model of mammary carcinoma. SeeFemel et al.

Table of Contents

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation

WW domain-containing oxidoreductase in neuronal injury and neurological diseases

ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age

A microRNA signature profile in EBV⁺ diffuse large B-cell lymphoma of the elderly

Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells.

The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells

Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells

Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells

Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

Transcriptomic profiling of taxol-resistant ovarian cancer cells identifies FKBP5 and the androgen receptor as critical markers of chemotherapeutic response

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2in vitro andin vivo

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma

The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases

Role of p53 in the progression of gastric cancer

Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation

PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells

AGK enhances angiogenesis and inhibits apoptosis via activation of the NF-κB signaling pathway in hepatocellular carcinoma

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway

MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma

E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis

Cooperative interactions between p53 and NFκB enhance cell plasticity

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling

MiR-520d-5p directly targets TWIST1 and downregulates the metastamiR miR-10b

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

Molecular profiling and computational network analysis of TAZ-mediated mammary tumorigenesis identifies actionable therapeutic targets

Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells

EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy

CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization

Prognostic significance of catalase expression and its regulatory effects on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas

GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma

ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma

Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway

MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer

Targeting cytosolic phospholipase A₂ α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation

The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models

Bortezomib induces AMPK-dependent autophagosome formation uncoupled from apoptosis in drug resistant cells

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model

Prognostic value of LAMP3 and TP53 overexpression in benign and malignant gastrointestinal tissues

Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: Analysis of 1806 cases

Early outcome prediction on 18F-fluorocholine PET/CT in metastatic castration-resistant prostate cancer patients treated with abiraterone

Increased number of negative lymph nodes is associated with improved cancer specific survival in pathological IIIB and IIIC rectal cancer treated with preoperative radiotherapy