| Director General | Oren Weinberg | 074-733-6100 |
| Chief Content Officer | Shai Nitzan | 074-733-6105 |
| Head of Technical Services | Orly Simon | 074-733-6432 |
| Head of Public Services | Tomer Hadad | 074-7336434 |
| Head of Information Systems | Itzik Burshan | 074-733-6333 |
| Head of Logistics and Operation | Ephrat Pomerantz | 074-733-6150 |
| Head of Culture and Visitors | Tsila Hayun | 074-733-6195 |
| Head of Education | Neta Shapira | 074-633-6352 |
| Head of Collections | Raquel Ukeles | 074-733-6281 |
| Head of Digital | Yaron Deutscher | 074-733-6341 |
| CFO | Chedva Knopf | 074-733-6120 |
| Human Resources Manager | Sarit Goldansky | 074-733-6193 |
| Head of International Relations & Partnerships | Naomi Schacter | 074-733-6106 |
| Senior Academic Advisor | Prof. Vered Noam | 074-733-6390 |
| Israel | Dr. Hezi Amiur | 074-733-6283 |
| Judaica | Dr. Chaim Meir Neria | 074-733-6112 |
| Humanities | Dr. Stefan Litt | 074-733-6282 |
| Islam and Middle East | Dr. Sam Thrope | 074-733-6433 |
| Music | Dr. Amalia Kedem | 074-733-6450 |
| Reference | Nachum Zitter | 074-733-6400 |
| Customer Experience | Tomer Hadad | 074-733-6434 |
| Call Center | Maya Marin | 074-733-6336 |
| Circulation | Liry Kaminer | 074-733-6414 |
| Interlibrary Loans | Zmira Reuveni | 074-733-6412 |
| Humanities and Islam Reading Room | Liry Kaminer | 074-733-6420 |
| Israel and Judaica Reading Room | Maayan Sasson | 074-733-6392 |
| Judaica Reference Librarian | Dr. Aliza Moreno | 074-733-6168 |
| Israel Reference Librarian | Dr. Galia Richler-Grebler | 074-733-6443 |
| Special Collections Reading Room | Alexander Gordin | 074-733-6480 |
| Archives | Matan Barzilai | 074-733-6265 |
| The Institute of Microfilmed Manuscripts | Yitzchack Gila | 074-733-6238 |
| Music and Sound Archive | Ohad Sofer | 074-733-6450 |
| Map Collections (Howard I. Golden, Eran Laor) | Ayelet Rubin | 074-733-6430 |
| Edelstein Collection | Dr. Shay Eshel | 074-733-6286 |
| Acquisition | Erez Elimelech | 074-733-6204 |
| Books Acquisition Department | Maya Zlotnikov-Golan | 074-733-6240 |
| Stacks Department | Alexis Lacher | 074-733-6130 |
| Head of Catalogue Department | Dr. Ahava Cohen | 074-733-6231 |
| Hebrew Catalogue Department | Veronika Leshchiner | 074-733-6242 |
| Foreign Language Catalogue Department | Ester Taga | 074-733-6290 |
| Arabic and Middle Eastern Languages Department | Bekriah Mawasi | 074-733-6336 |
| Union List of Serials Department | Ariel Lock | 074-733-6227 |
| RAMBI/Classification | Aviad Rosenberg | 074-733-6216 |
| Restoration Department | Marcela Szekely | 074-733-6250 |
| Photocopying and Scanning Room | Elishema Atias | 074-733-6317 |
| External Exhibitions | Netanel Moses | 074-733-6014 |
| Serials DB Shelflist and Book Bindery | Alexis Lacher | 074-733-6130 |
| Head of Culture Department | Ruty Rubinshtein | 074-733-6180 |
| Head of Visitors Center | Tamar Sorek | 074-633-6197 |
| Exhibitions Curator | Netta Assaf | 074-733-6339 |
| Head of Marketing | Amir Orni | 074-733-6438 |
| Head of Digital Content | Nati Gabbay | 074-733-6219 |
| Spokesperson | Vered Lyon-Yerushalmi | |
| Resource Development – Israel | Irit Jacobowitz | 074-7336362 |
| International Media Relations | Rachel Neiman | 074-733-6152 |
| Aharon Cohen | 1892-1920 |
| Schmuel Hugo Bergman | 1920-1935 |
| Gotthold Weil | 1935-1946 |
| David Hartwig | 1946-1947 |
| Curt David Wormann | 1947-1968 |
| Issachar Joel | 1968-1969 |
| Israel Adler | 1969-1971 |
| Peretz Tishby | 1971-1972 |
| Roy Mersky | 1972-1973 |
| Reuven Yaron | 1973-1978 |
| Malachi Beit-Arie | 1978-1990 |
| Israel Shatzman | 1990-1997 |
| Sara Japhet | 1997-2001 |
| Yoram Tsafrir | 2001-2005 |
| Rosalind Duke | 2005-2006 |
| Doron Avital | April-November 2006 |
| Shmuel Har-Noy | 2007-2009 |
| Oren Weinberg | January 2010-present |
