(Images from Chapter 21 of Pathology of Genetically Engineered Mice (2000). JM Ward, JF Mahler, RR Maronpot, JP Sundberg, Eds. with permission of Iowa State University Press, Ames, Iowa)

Gross appearance of a liver with multiple hepatic neoplasms.

Hepatitis B surface antigen in hepatocytes of an HBV transgenic mouse. Immunohistochemistry stain counterstained with hematoxylin.

Hepatitis B surface antigen is absent in a preneoplastic focus from an HBV transgenic mouse. Immunohistochemistry stain counterstained with hematoxylin.

Hepatocellular adenoma in an HBV transgenic mouse. Arrows indicate compression of adjacent hepatic parenchyma.