Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Branch
Chad Blystone, Ph.D., D.A.B.T., is a toxicologist in the Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. He serves as a study scientist for chemicals selected for toxicity and carcinogenicity evaluation by the NTP. Currently he is the lead on studies evaluating chemicals within the classes of parabens, phthalates, ethylene glycol ethers and perfluoroalkyl acids. These studies includein vitro andin vivo evaluation of toxicity, toxicokinetics, absorption, disposition, metabolism and excretion of the chemical. He has a particular interest in elucidating chemical toxicity to reproduction and development, developmental basis of disease, and the adverse effects from chemical mixtures.
Blystone received a B.S. in zoology from Auburn University, Auburn, Alabama, an M.S. in zoology from Miami University, Oxford, Ohio, and a Ph.D. in toxicology from North Carolina State University, Raleigh, North Carolina. He completed postdoctoral work at the National Health and Environmental Effects Research Laboratory within the U. S. Environmental Protection Agency, and at the NTP at the NIEHS. Blystone joined the NTP in 2009.
Recent Publications
- Shipkowski K, Cora M, Cesta M, Robinson V, Waidyanatha S, Witt K, Vallant M, Fallacara D, Hejtmancik M, Masten S, Cooper S, Fernando R, Blystone C. Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage.Toxicology reports. 2021;8:581-591. [ AbstractShipkowski K, Cora M, Cesta M, Robinson V, Waidyanatha S, Witt K, Vallant M, Fallacara D, Hejtmancik M, Masten S, Cooper S, Fernando R, Blystone C. Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage. Toxicology reports. 2021]
- Huang M, Dzierlenga A, Robinson V, Waidyanatha S, DeVito M, Eifrid M, Granville C, Gibbs S, Blystone C. Corrigendum to "Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration" [Toxicol. Rep. 6 (2019) 645-655].Toxicology reports. 2021;8:365. [ AbstractHuang M, Dzierlenga A, Robinson V, Waidyanatha S, DeVito M, Eifrid M, Granville C, Gibbs S, Blystone C. Corrigendum to "Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration" [Toxicol. Rep. 6 (2019) 645-655]. Toxicology reports. 2021]
- Watson A, Johnson V, Luster M, Burleson G, Fallacara D, Sparrow B, Cesta M, Cora M, Shockley K, Stout M, Blystone C, Germolec D. Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice.Journal of immunotoxicology. 2021 Dec;18(1):1-12. [ AbstractWatson A, Johnson V, Luster M, Burleson G, Fallacara D, Sparrow B, Cesta M, Cora M, Shockley K, Stout M, Blystone C, Germolec D. Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice. Journal of immunotoxicology. 2021 Dec]
- Watson A, Moeller B, Doyle-Eisele M, Garner E, Blystone C, McDonald J, Waidyanatha S. Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, andin vitro in rat hepatocytes.Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jun;51(6):689-702. [ AbstractWatson A, Moeller B, Doyle-Eisele M, Garner E, Blystone C, McDonald J, Waidyanatha S. Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, andin vitro in rat hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jun]
- Hubbard T, Brix A, Blystone C, McIntyre B, Shockley K, Cunny H, Waidyanatha S, Turner K, McBride S, Roberts G. Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure.Reproductive toxicology (Elmsford, N.Y.). 2020 Sep;96:258-272. [ AbstractHubbard T, Brix A, Blystone C, McIntyre B, Shockley K, Cunny H, Waidyanatha S, Turner K, McBride S, Roberts G. Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure. Reproductive toxicology (Elmsford, N.Y.). 2020 Sep]
NTP Reports
- National Toxicology Program. Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice.Toxicity report series. 2024 Oct [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice. Toxicity report series. 2024 Oct]
- National Toxicology Program. Toxicology and carcinogenesis study of triclosan administered dermally to B6C3F1/N mice.National Toxicology Program technical report series. 2024 May [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis study of triclosan administered dermally to B6C3F1/N mice. National Toxicology Program technical report series. 2024 May]
- National Toxicology Program. Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice.National Toxicology Program technical report series. 2023 Dec [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice. National Toxicology Program technical report series. 2023 Dec]
- National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.National Toxicology Program technical report series. 2023 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun]
- National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.Toxicity report series. 2023 Mar [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar]
Related Links
- PFOA evaluated for cancer links by NTP expert panel - Environmental Factor, January 2020