Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
The Predictive Toxicology Branch (PTB) partners across the NIEHSDivision of Translational Toxicology (DTT) to develop and apply innovative approaches to predict human-relevant health effects from agents of interest to DTT. DTT is a team-based scientific organization, and its mission is to improve public health through development of data and knowledge that are translatable, predictive, and timely.
Capabilities of the Branch include the development, validation, and application of computational tools, dose-response models, and systems toxicology models. The Branch serves as the DTT lead for key partnerships such as the interagencyTox21 Program and theInteragency Coordinating Committee on the Validation of Alternative Methods (ICCVAM).
The goals of PTB are carried out by the following groups.
- NTP Interagency Center for the Evaluation of Alternative Toxicological Methods
- Spatiotemporal Exposures and Toxicology Group
- Toxicoinformatics Group
PTB scientists contribute toNTP report and monograph series and publish findings in theNIEHS report series and peer-reviewed scientific literature.Staff publications can be viewed on the webpage.
Chief
- Agencies advised on reducing animal testing, embracing alternatives - Environmental Factor, November 2021
- Moving away from animal-based antibodies - Environmental Factor, January 2020
- Tox21: Understanding the Potential Health Risks of Chemicals (442KB) (442KB)