Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
David Crizer, Ph.D., is a chemist in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Before joining DTT he completed his doctorate in Analytical Chemistry at the University of North Carolina at Chapel Hill under the direction of Gary Glish. At UNC his dissertation research focused on the use of mass spectrometry, differential ion mobility, and theoretical chemistry to understand novel ion chemistries.
His work at DTT is focused on the development of mass spectrometry-based untargeted metabolomic methods to aid in the screening of potentially toxic substances. His research also includes analytical method development for hepatic clearance assays, specific activity assays, and metabolite profiling assays. Other interests include the investigation of in silico metabolite prediction and how predictions compare toin vitro data.
Crizer obtained his B.S. in Chemistry from James Madison University followed by a Ph.D. in Analytical Chemistry from University of North Carolina at Chapel Hill.
Recent Publications
- Scherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays.Environmental science & technology. 2026 Feb 02 [Epub ahead of print]. [ AbstractScherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays. Environmental science & technology. 2026 Feb 02]
- Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories.Toxics. 2024 Sep 14;12(9):. [ AbstractCrizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14]
- Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay.Chemical research in toxicology. 2024 Jun 17;37(6):923-934. [ AbstractSostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay. Chemical research in toxicology. 2024 Jun 17]
- Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.Archives of toxicology. 2024 Apr;98(4):1111-1123. [ AbstractViant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr]
- Crizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models.Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27;181(2):175-186. [ AbstractCrizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27]
NTP Reports
- National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12NTP Research Reports. 2019 Jul [Epub ahead of print]. [ AbstractNational Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul]
- Insight into how metabolites affect health aided by new data platforms - Environmental Factor, January 2022
- To study metabolome, a hybrid approach is needed, expert says - Environmental Factor, August 2021
- Novel toxicity assessment strategies highlighted at DNTP board meeting - Environmental Factor, July 2021