Publications

• Lloyd D, House JS, Akhtari FS, Schmitt CP, Fargo DC, Scholl EH, Phillips J, Choksi S, Shah R, Hall JE, Motsinger-Reif AA. Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study.Exposome. 2024 Feb 12;4(1):osae002. doi: 10.1093/exposome/osae002. [Abstract]
• Lloyd D, House JS, Akhtari FS, Schmitt CP, Fargo DC, Scholl EH, Phillips J, Choksi S, Shah R, Hall JE, Motsinger-Reif AA. Interactive data sharing for multiple questionnaire-based exposome-wide association studies and exposome correlations in the Personalized Environment and Genes Study.Exposome. 2024 Feb 12;4(1):osae003. doi: 10.1093/exposome/osae003. [Abstract]
• Mack JA, Burkholder AB, Akhtari FS, House JS, Sovio U, Smith GSC, Schmitt CP, Fargo DC, Hall JE, Motsinger-Reif AA. A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy.medRxiv. 2023.10. 30.23297806. doi: 10.1101/2023.10.30.23297806. [Abstract]
• Lee EY, Choi W, Burkholder AB, Perera L, Mack JA, Miller FW, Fessler MB, Cook DN, Karmaus PWF, Nakano H, Garantziotis S, Madenspacher JH, House JS, Akhtari FS, Schmitt CS, Fargo DC, Hall JE, Motsinger-Reif AA. Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma.Front Genet. 2023 Jun 21;14:1173676. doi: 10.3389/fgene.2023.1173676. [Abstract]
• Ayala-Ramirez M, MacNell N, McNamee LE, McGrath JA, Akhtari FS, Curry MD, Dunnon AK, Fessler MB, Garantziotis S, Parks CG, Fargo DC, Schmitt CP, Motsinger-Reif AA, Hall JE, Miller FW, Schurman SH. Association of distance to swine concentrated animal feeding operations with immune-mediated diseases: An exploratory gene-environment study.Environ Int. 2023;171:107687. [AbstractAyala-Ramirez M, MacNell N, McNamee LE, McGrath JA, Akhtari FS, Curry MD, Dunnon AK, Fessler MB, Garantziotis S, Parks CG, Fargo DC, Schmitt CP, Motsinger-Reif AA, Hall JE, Miller FW, Schurman SH. Association of distance to swine concentrated animal feeding operations with immune-mediated diseases: An exploratory gene-environment study. Environ Int. 2023;171:107687.]
• Lowe ME, Akhtari FS, Potter TA, Fargo DC, Schmitt CP, Schurman SH, Eccles KM, Motsinger-Reif A, Hall JE, Messier KP. The skin is no barrier to mixtures: Air pollutant mixtures and reported psoriasis or eczema in the Personalized Environment and Genes Study (PEGS) [published online ahead of print, 2022 Dec 2].J Expo Sci Environ Epidemiol. J Expo Sci Environ Epidemiol. 2022;10.1038/s41370-022-00502-0. [AbstractLowe ME, Akhtari FS, Potter TA, Fargo DC, Schmitt CP, Schurman SH, Eccles KM, Motsinger-Reif A, Hall JE, Messier KP. The skin is no barrier to mixtures: Air pollutant mixtures and reported psoriasis or eczema in the Personalized Environment and Genes Study (PEGS) [published online ahead of print, 2022 Dec 2]. J Expo Sci Environ Epidemiol. J Expo Sci Environ Epidemiol. 2022;10.1038/s41370-022-00502-0.]
• Akhtari FS, Lloyd D, Burkholder A, Tong X, House JS, Lee EY, Buse J, Schurman SH, Fargo DC, Schmitt CP, Hall J, Motsinger-Reif AA. Questionnaire-based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort [published online ahead of print, 2022 Nov 16].Diabetes Care. 2022;dc220295. [AbstractAkhtari FS, Lloyd D, Burkholder A, Tong X, House JS, Lee EY, Buse J, Schurman SH, Fargo DC, Schmitt CP, Hall J, Motsinger-Reif AA. Questionnaire-based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort [published online ahead of print, 2022 Nov 16]. Diabetes Care. 2022;dc220295.]
• Lee EY, Akhtari F, House JS, Simpson RJ Jr, Schmitt CP, Fargo DC, Schurman SH, Hall JE, Motsinger-Reif AA. Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study.Environ Res. 2022;212(Pt D):113463. [AbstractLee EY, Akhtari F, House JS, Simpson RJ Jr, Schmitt CP, Fargo DC, Schurman SH, Hall JE, Motsinger-Reif AA. Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study. Environ Res. 2022;212(Pt D):113463.]
• Schupmann W, Miner SA, Sullivan HK, Glover JR, Hall JE, Schurman SH, Berkman BE. Exploring the motivations of research participants who chose not to learn medically actionable secondary genetic findings about themselves.Genet Med. 2021 Dec;23(12):2281-2288. [AbstractSchupmann W, Miner SA, Sullivan HK, Glover JR, Hall JE, Schurman SH, Berkman BE. Exploring the motivations of research participants who chose not to learn medically actionable secondary genetic findings about themselves. Genet Med. 2021 Dec;23(12):2281-2288.]
• Saini N, Giacobone CK, Klimczak LJ, Papas BN, Burkholder AB, Li JL, Fargo DC, Bai R, Gerrish K, Innes CL, Schurman SH, Gordenin DA. UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.PLoS Genet. 2021 Jan 14;17(1):e1009302. [AbstractSaini N, Giacobone CK, Klimczak LJ, Papas BN, Burkholder AB, Li JL, Fargo DC, Bai R, Gerrish K, Innes CL, Schurman SH, Gordenin DA. UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. PLoS Genet. 2021 Jan 14;17(1):e1009302.]
• Fecho K, Haaland P, Krishnamurthy A, Lan B, Ramsey SA, Schmitt PL, Sharma P, Sinha M, Xu H. An approach for open multivariate analysis of integrated clinical and environmental exposures data.Informatics in Medicine Unlocked. 2021; Volume 26, 100733. [AbstractFecho K, Haaland P, Krishnamurthy A, Lan B, Ramsey SA, Schmitt PL, Sharma P, Sinha M, Xu H. An approach for open multivariate analysis of integrated clinical and environmental exposures data. Informatics in Medicine Unlocked. 2021; Volume 26, 100733.]
• Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV Jr, Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T. The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.Cancer Epidemiol Biomarkers Prev. 2020 Jul; 29(7):1283-1289. [AbstractChan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV Jr, Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T. The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action. Cancer Epidemiol Biomarkers Prev. 2020 Jul; 29(7):1283-1289.]
• Drew DA, Nguyen LH, Steves CJ, Menni C, Freydin M, Varsavsky T, Sudre CH, Cardoso MJ, Ourselin S, Wolf J, Spector TD, Chan AT. Rapid implementation of mobile technology for real-time epidemiology of COVID-19.Science. 2020 Jun 19; 368(6497):1362-1367. [AbstractDrew DA, Nguyen LH, Steves CJ, Menni C, Freydin M, Varsavsky T, Sudre CH, Cardoso MJ, Ourselin S, Wolf J, Spector TD, Chan AT. Rapid implementation of mobile technology for real-time epidemiology of COVID-19. Science. 2020 Jun 19; 368(6497):1362-1367.]
• Whitehead GS, Hussain S, Fannin R, Trempus CS, Innes CL, Schurman SH, Cook DN, Garantziotis S. TLR5 Activation Exacerbates Airway Inflammation in Asthma.Lung. 2020 Apr;198(2):289-298. [AbstractWhitehead GS, Hussain S, Fannin R, Trempus CS, Innes CL, Schurman SH, Cook DN, Garantziotis S. TLR5 Activation Exacerbates Airway Inflammation in Asthma. Lung. 2020 Apr;198(2):289-298.]
• Schurman SH, O'Hanlon TP, McGrath JA, Gruzdev A, Bektas A, Xu H, Garantziotis S, Zeldin DC, Miller FW. Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.J Autoimmun. 2020 Feb;107:102363. [AbstractSchurman SH, O'Hanlon TP, McGrath JA, Gruzdev A, Bektas A, Xu H, Garantziotis S, Zeldin DC, Miller FW. Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene. J Autoimmun. 2020 Feb;107:102363.]
• Valencia A, Stillwell L, Appold S, Arunachalam S, Cox S, Xu H, Schmitt CP, Schurman SH, Garantziotis S, Xue W, Ahalt SC, Fecho K. Translator Exposure APIs: Open Access to Data on Airborne Pollutant Exposures, Roadway Exposures, and Socio-Environmental Exposures and Use Case Application.Int J Environ Res Public Health. 2020;17(14):5243. [AbstractValencia A, Stillwell L, Appold S, Arunachalam S, Cox S, Xu H, Schmitt CP, Schurman SH, Garantziotis S, Xue W, Ahalt SC, Fecho K. Translator Exposure APIs: Open Access to Data on Airborne Pollutant Exposures, Roadway Exposures, and Socio-Environmental Exposures and Use Case Application. Int J Environ Res Public Health. 2020;17(14):5243.]
• Ajayi T, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB. Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G95-G105. PMID: 30335469. [AbstractAjayi T, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB. Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G95-G105. PMID: 30335469.]
• Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA. p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.J Clin Invest. 2019; 129(11):4875-4884. [AbstractMenendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA. p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus. J Clin Invest. 2019; 129(11):4875-4884.]
• Schurman S, Bravo M, Innes C, Jackson II WB, McGrath J, Miranda ML, Garantziotis S. Toll-like Receptor 4 Pathway Polymorphisms Interact with Pollution to Influence Asthma Diagnosis and Severity.Sci Rep. 2018 Aug 23;8(1):12713. PMID: 30140039 PMCID: PMC6107668. [AbstractSchurman S, Bravo M, Innes C, Jackson II WB, McGrath J, Miranda ML, Garantziotis S. Toll-like Receptor 4 Pathway Polymorphisms Interact with Pollution to Influence Asthma Diagnosis and Severity. Sci Rep. 2018 Aug 23;8(1):12713. PMID: 30140039 PMCID: PMC6107668.]
• Whirledge SD, Jewell CM, Barber LM, Xu X, Katen KS, Garantziotis S, Cidlowski JA. Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor.Lab Invest 97. 2017 Jul; 1282–1295 (2017). [AbstractWhirledge SD, Jewell CM, Barber LM, Xu X, Katen KS, Garantziotis S, Cidlowski JA. Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor. Lab Invest 97. 2017 Jul; 1282–1295 (2017).]
• Jewell CM, Katen KS, Barber LM, Cannon C, Garantziotis S, Cidlowski JA. Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome.American Journal of Physiology - Endocrinology and Metabolism. 2016 Oct 1;311(4):E741-E748. [AbstractJewell CM, Katen KS, Barber LM, Cannon C, Garantziotis S, Cidlowski JA. Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome. American Journal of Physiology - Endocrinology and Metabolism. 2016 Oct 1;311(4):E741-E748.]
• Gale SC, Gao L, Mikacenic C, Coyle SM, Rafaels N, Murray Dudenkov T, Madenspacher JH, Draper DW, Ge W, Aloor JJ, Azzam KM, Lai L, Blackshear PJ, Calvano SE, Barnes KC, Lowry SF, Corbett S, Wurfel MM, Fessler MB. APOε4 is associated with enhanced in vivo innate immune responses in human subjects.Journal of Allergy and Clinical Immunology 2014 Jul;134(1):127-34. [AbstractGale SC, Gao L, Mikacenic C, Coyle SM, Rafaels N, Murray Dudenkov T, Madenspacher JH, Draper DW, Ge W, Aloor JJ, Azzam KM, Lai L, Blackshear PJ, Calvano SE, Barnes KC, Lowry SF, Corbett S, Wurfel MM, Fessler MB. APOε4 is associated with enhanced in vivo innate immune responses in human subjects. Journal of Allergy and Clinical Immunology 2014 Jul;134(1):127-34.]
• Pu D, Garantziotis S, Mostafa J. Anonymous Record Linkage Between EPR and CDW-H: Toward Development of a Federated Genotype-Phenotype System.AMIA Jt Summits Transl Sci Proc. 2013 Mar 18; 2013:143-6. [AbstractPu D, Garantziotis S, Mostafa J. Anonymous Record Linkage Between EPR and CDW-H: Toward Development of a Federated Genotype-Phenotype System. AMIA Jt Summits Transl Sci Proc. 2013 Mar 18; 2013:143-6.]
• Michie M, Cadigan RJ, Henderson G, Beskow LM. Am I a control?: Genotype-driven research recruitment and self-understandings of study participants.Genetics in Medicine 2012 Dec;14(12):983-9. [AbstractMichie M, Cadigan RJ, Henderson G, Beskow LM. Am I a control?: Genotype-driven research recruitment and self-understandings of study participants. Genetics in Medicine 2012 Dec;14(12):983-9.]
• Beskow LM, Namey EE, Cadigan RJ, Brazg T, Crouch J, Henderson GE, Michie M, Nelson DK, Tabor HK, Wilfond BS. Research participants’ perspectives on genotype-driven research recruitment.Journal of Empirical Research on Human Research Ethics 2011. Dec;6(4):3-20. [AbstractBeskow LM, Namey EE, Cadigan RJ, Brazg T, Crouch J, Henderson GE, Michie M, Nelson DK, Tabor HK, Wilfond BS. Research participants’ perspectives on genotype-driven research recruitment. Journal of Empirical Research on Human Research Ethics 2011. Dec;6(4):3-20.]
• Chulada PC, Vainorius E, Garantziotis S, Burch LH, Blackshear PJ, Zeldin, DC. The environmental polymorphisms registry: a unique resource that facilitates translational research of environmental disease.Environmental Health Perspectives 2011 Nov;119(11):1523-7. [AbstractChulada PC, Vainorius E, Garantziotis S, Burch LH, Blackshear PJ, Zeldin, DC. The environmental polymorphisms registry: a unique resource that facilitates translational research of environmental disease. Environmental Health Perspectives 2011 Nov;119(11):1523-7.]
• Menendez D, Shatz M, Azzam K, Garantziotis S, Fessler MB, Resnick MA. The Toll-Like Receptor Gene Family is Integrated into Human DNA Damage and p53 Networks.PLOS Genetics 2011 Mar;7(3):e1001360. [AbstractMenendez D, Shatz M, Azzam K, Garantziotis S, Fessler MB, Resnick MA. The Toll-Like Receptor Gene Family is Integrated into Human DNA Damage and p53 Networks. PLOS Genetics 2011 Mar;7(3):e1001360.]
• Chulada PC, Vahdat HL, Sharp RR, DeLozier TC, Watkins PB, Pusek SN, Blackshear PJ. The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci.Human Genetics 2008 Mar;123(2):207-14. [AbstractChulada PC, Vahdat HL, Sharp RR, DeLozier TC, Watkins PB, Pusek SN, Blackshear PJ. The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci. Human Genetics 2008 Mar;123(2):207-14.]
• Spivey A. Environmental Polymorphism Registry: DNA to discover the source of susceptibility.Environmental Health Perspectives 2006 Jul; 114(7): A408–A409. [AbstractSpivey A. Environmental Polymorphism Registry: DNA to discover the source of susceptibility. Environmental Health Perspectives 2006 Jul; 114(7): A408–A409.]
• Carrick DM, Chulada, P, Donn R, Fabris M, McNicholl J, Whitworth W, Blackshear PJ. Genetic variations in ZFP36 and their possible relationship to autoimmune diseases.Journal of Autoimmunity 2006 May;26(3):182-96. [AbstractCarrick DM, Chulada, P, Donn R, Fabris M, McNicholl J, Whitworth W, Blackshear PJ. Genetic variations in ZFP36 and their possible relationship to autoimmune diseases. Journal of Autoimmunity 2006 May;26(3):182-96.]
• Spivey A. Gene-environment studies: who, how, when, and where?.Environ Health Perspect. 2006;114(8):A466-A467. [AbstractSpivey A. Gene-environment studies: who, how, when, and where?. Environ Health Perspect. 2006;114(8):A466-A467.]