Experimental transmission of hepatitis B virus by semen and saliva
- PMID:7400629
- DOI: 10.1093/infdis/142.1.67
Experimental transmission of hepatitis B virus by semen and saliva
Abstract
The ability of human semen and saliva to transmit hepatitis B virus (HBV) by parenteral and nonparenteral routes was studied. Semen, donated by a hepatitis B surface antigen (HBsAg)- and hepatitis B e antigen (HBeAg)-positive carrier, was administered to one gibbon by subcutaneous inoculation and to another by intravaginal instillation. Both developed HBsAg, followed by the development of antibody to HBsAg (anti-HBs) and antibody to hepatitis B core antigen (anti-HBc). Saliva from two donors who were HBsAg- and HBeAg-positive was pooled and administered subcutaneously to two gibbons and orally to five others. The animals inoculated subcutaneously developed HBsAg followed by anti-HBs, but none of the gibbons exposed orally developed evidence of HBV infection. Thus, semen and saliva of HBsAg carriers can be infectious, and venereal transmission of HBV by semen can occur. Transmission of HBV in saliva can also occur through breaks in the skin, but experimental transmission of HBV by saliva administered orally has not been accomplished.
Similar articles
- Transmission of hepatitis B to chimpanzees by hepatitis B surface antigen-positive saliva and semen.Alter HJ, Purcell RH, Gerin JL, London WT, Kaplan PM, McAuliffe VJ, Wagner J, Holland PV.Alter HJ, et al.Infect Immun. 1977 Jun;16(3):928-33. doi: 10.1128/iai.16.3.928-933.1977.Infect Immun. 1977.PMID:892901Free PMC article.
- Transmission of hepatitis B virus to gibbons by exposure to human saliva containing hepatitis B surface antigen.Bancroft WH, Snitbhan R, Scott RM, Tingpalapong M, Watson WT, Tanticharoenyos P, Karwacki JJ, Srimarut S.Bancroft WH, et al.J Infect Dis. 1977 Jan;135(1):79-85. doi: 10.1093/infdis/135.1.79.J Infect Dis. 1977.PMID:833450
- Transmission of hepatitis B infection from hepatitis B core antibody--positive liver allografts is prevented by lamivudine therapy.Yu AS, Vierling JM, Colquhoun SD, Arnaout WS, Chan CK, Khanafshar E, Geller SA, Nichols WS, Fong TL.Yu AS, et al.Liver Transpl. 2001 Jun;7(6):513-7. doi: 10.1053/jlts.2001.23911.Liver Transpl. 2001.PMID:11443579
- Occult hepatitis B virus infection.Allain JP.Allain JP.Transfus Clin Biol. 2004 Feb;11(1):18-25. doi: 10.1016/j.tracli.2003.11.007.Transfus Clin Biol. 2004.PMID:14980545Review.
- Occult hepatitis B virus infection: implications in transfusion.Allain JP.Allain JP.Vox Sang. 2004 Feb;86(2):83-91. doi: 10.1111/j.0042-9007.2004.00406.x.Vox Sang. 2004.PMID:15023176Review.
Cited by
- Relationship between age and prevalence of hepatitis B infection in first-year university students in Hong Kong.Suen SS, Lao TT, Chan OK, Lau TK, Leung TY, Chan PK.Suen SS, et al.Infection. 2013 Apr;41(2):529-35. doi: 10.1007/s15010-012-0379-6. Epub 2012 Dec 12.Infection. 2013.PMID:23233215
- Impact of neonatal hepatitis B vaccination programme on age-specific prevalence of hepatitis B infection in teenage mothers in Hong Kong.Lao TT, Sahota DS, Suen SS, Chan PK, Leung TY.Lao TT, et al.Epidemiol Infect. 2013 Oct;141(10):2131-9. doi: 10.1017/S0950268812002701. Epub 2012 Dec 5.Epidemiol Infect. 2013.PMID:23211684Free PMC article.
- Exposure to hepatitis B: review of current concepts.Zimmerman FH, Wormser GP.Zimmerman FH, et al.Bull N Y Acad Med. 1989 Sep;65(7):741-56.Bull N Y Acad Med. 1989.PMID:2695200Free PMC article.Review.No abstract available.
- Signature of chronic hepatitis B virus infection in nails and hair.Komatsu H, Inui A, Odmaa E, Ito Y, Hoshino H, Umetsu S, Tsunoda T, Fujisawa T.Komatsu H, et al.BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.BMC Infect Dis. 2022.PMID:35509029Free PMC article.
- A sensitive and rapid assay for investigating vertical transmission of hepatitis B virus via male germ line using EGFP Vector as reporter.Ahmed MM, Huang TH, Xie QD.Ahmed MM, et al.J Biomed Biotechnol. 2008;2008:495436. doi: 10.1155/2008/495436.J Biomed Biotechnol. 2008.PMID:18670607Free PMC article.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical