Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis
- PMID:36206958
- DOI: 10.1016/j.phrs.2022.106484
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis
Abstract
Background: Vitamin D supplementation has attracted a lot of attention as a potential modulator of inflammation and oxidative stress, while some studies have reported controversial findings. In this regard, the purpose of this study was to summarize existing systematic reviews and meta-analyses of clinical trials that determined the effects of supplementation with vitamin D on inflammatory and oxidative biomarkers.
Methods: The following international databases were systematically searched till March 20th, 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of vitamin D on inflammatory and oxidative stress biomarkers.
Results: Overall, 23 meta-analyses were qualified in this umbrella meta-analysis. Our findings revealed that the vitamin D supplementation significantly reduced serum C-reactive protein (CRP) (ES = -0.42; 95% CI: -0.55, -0.29, p < 0.001), tumor necrosis factor-α (TNF-α) (ES = -0.27; 95% CI: -0.42, -0.12; p < 0.001), and malondialdehyde (MDA) concentrations (ES = -0.37; 95% CI: -0.48, -0.25, p < 0.001). However, no significant changes were illustrated regarding interleukin-6 (IL-6) (ES = -0.35, 95% CI: -0.80, 0.10; p = 0.125), total antioxidant capacity (TAC) (ES = 0.68; 95% CI: -0.31, 1.66, p = 0.179), and glutathione (GSH) activity (ES = 0.08; 95% CI: -0.44, 0.60, p = 0.757).
Conclusion: The present umbrella meta-analysis indicated that supplementation of vitamin D in adults can improve CRP, TNF-α, and MDA levels under various health conditions. Vitamin D could be considered an adjuvant therapy for relieving inflammation and oxidative stress.
Keywords: Inflammation; Meta-analysis; Oxidative stress; Vitamin D.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Conflicts of interest No conflict of interest to declare.
Similar articles
- The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Mansournia MA, Ostadmohammadi V, Doosti-Irani A, Ghayour-Mobarhan M, Ferns G, Akbari H, Ghaderi A, Talari HR, Asemi Z.Mansournia MA, et al.Horm Metab Res. 2018 Jun;50(6):429-440. doi: 10.1055/a-0630-1303. Epub 2018 Jun 8.Horm Metab Res. 2018.PMID:29883970Review.
- The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials.Motamed S, Nikooyeh B, Anari R, Motamed S, Mokhtari Z, Neyestani T.Motamed S, et al.BMC Pregnancy Childbirth. 2022 Nov 5;22(1):816. doi: 10.1186/s12884-022-05132-w.BMC Pregnancy Childbirth. 2022.PMID:36335311Free PMC article.
- Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis.Kavyani Z, Musazadeh V, Fathi S, Hossein Faghfouri A, Dehghan P, Sarmadi B.Kavyani Z, et al.Int Immunopharmacol. 2022 Oct;111:109104. doi: 10.1016/j.intimp.2022.109104. Epub 2022 Jul 30.Int Immunopharmacol. 2022.PMID:35914448Review.
- Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM.Hoseini R, Rahim HA, Ahmed JK.Hoseini R, et al.BMC Complement Med Ther. 2022 Jun 22;22(1):165. doi: 10.1186/s12906-022-03645-7.BMC Complement Med Ther. 2022.PMID:35733163Free PMC article.Clinical Trial.
- The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Akbari M, Ostadmohammadi V, Lankarani KB, Tabrizi R, Kolahdooz F, Heydari ST, Kavari SH, Mirhosseini N, Mafi A, Dastorani M, Asemi Z.Akbari M, et al.Horm Metab Res. 2018 Apr;50(4):271-279. doi: 10.1055/s-0044-101355. Epub 2018 Feb 23.Horm Metab Res. 2018.PMID:29475212Review.
Cited by
- Tumor Microbial Communities and Thyroid Cancer Development-The Protective Role of Antioxidant Nutrients: Application Strategies and Future Directions.Gorini F, Tonacci A.Gorini F, et al.Antioxidants (Basel). 2023 Oct 23;12(10):1898. doi: 10.3390/antiox12101898.Antioxidants (Basel). 2023.PMID:37891977Free PMC article.Review.
- Vitamin D deficiency prevention policies in Iran: a retrospective policy analysis.Aghapour B, Kheirouri S, Alizadeh M, Khodayari-Zarnaq R.Aghapour B, et al.Front Nutr. 2023 Aug 23;10:1249402. doi: 10.3389/fnut.2023.1249402. eCollection 2023.Front Nutr. 2023.PMID:37680901Free PMC article.
- The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?Rust P, Ekmekcioglu C.Rust P, et al.Int J Environ Res Public Health. 2023 Apr 4;20(7):5400. doi: 10.3390/ijerph20075400.Int J Environ Res Public Health. 2023.PMID:37048015Free PMC article.Review.
- Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World.Kacemi R, Campos MG.Kacemi R, et al.Nutrients. 2023 May 22;15(10):2413. doi: 10.3390/nu15102413.Nutrients. 2023.PMID:37242296Free PMC article.
- Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions.Vázquez-Lorente H, Herrera-Quintana L, Jiménez-Sánchez L, Fernández-Perea B, Plaza-Diaz J.Vázquez-Lorente H, et al.Antioxidants (Basel). 2024 Aug 17;13(8):996. doi: 10.3390/antiox13080996.Antioxidants (Basel). 2024.PMID:39199241Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous