Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
- PMID:16753311
- DOI: 10.1016/j.cellbi.2006.04.002
Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
Abstract
Theodor Boveri (1862-1915) is often credited with suggesting (in 1914) the first chromosomal theory of cancer, especially in terms of abnormal numbers of chromosomes arising in cells by multipolar mitoses in adult cells. However, multipolar mitoses in animal cells had been described as early as 1875, and Hansemann (1858-1920), in publications between 1890 and 1919, included this mechanism among various ways by which abnormal chromosome numbers might arise in cells and cause tumour formation. Both theories were conceived in a period when gametogenic ideas of tumour formation were current. Boveri based his theory on the observation that some cells in early sea urchin embryos having abnormal chromosome complements wander from their usual developmental paths. His observation may have been seen by other authors at the time as support for Cohnheim's "embryonic cell rest" theory of cancer. Hansemann's contribution is seen as both the original, and the more significant of the chromosomal theories of cancer.
Similar articles
- Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors.Hardy PA, Zacharias H.Hardy PA, et al.Cell Biol Int. 2005 Dec;29(12):983-92. doi: 10.1016/j.cellbi.2005.10.001. Epub 2005 Nov 28.Cell Biol Int. 2005.PMID:16314117Review.
- ["He corrects my view and develops it further." Comments by David von Hansemann on the monograph by Theodor Boveri Concerning the origin of malignant tumors (1914)].Wunderlich V.Wunderlich V.Ber Wiss. 2011 Sep;34(3):263-83. doi: 10.1002/bewi.201101505.Ber Wiss. 2011.PMID:22043658German.
- Theodor and Marcella Boveri: chromosomes and cytoplasm in heredity and development.Satzinger H.Satzinger H.Nat Rev Genet. 2008 Mar;9(3):231-8. doi: 10.1038/nrg2311.Nat Rev Genet. 2008.PMID:18268510Review.
- Boveri at 100: Theodor Boveri and genetic predisposition to cancer.Hansford S, Huntsman DG.Hansford S, et al.J Pathol. 2014 Oct;234(2):142-5. doi: 10.1002/path.4414.J Pathol. 2014.PMID:25074498
- The three-dimensional cancer nucleus.Mai S.Mai S.Genes Chromosomes Cancer. 2019 Jul;58(7):462-473. doi: 10.1002/gcc.22720. Epub 2019 Jan 21.Genes Chromosomes Cancer. 2019.PMID:30536826Review.
Cited by
- Overactivation of Ras signaling pathway in CD133+ MPNST cells.Borrego-Diaz E, Terai K, Lialyte K, Wise AL, Esfandyari T, Behbod F, Mautner VF, Spyra M, Taylor S, Parada LF, Upadhyaya M, Farassati F.Borrego-Diaz E, et al.J Neurooncol. 2012 Jul;108(3):423-34. doi: 10.1007/s11060-012-0852-1. Epub 2012 Apr 8.J Neurooncol. 2012.PMID:22484909
- Differential expression of centrosomal proteins at different stages of human glioma.Loh JK, Lieu AS, Chou CH, Lin FY, Wu CH, Howng SL, Chio CC, Hong YR.Loh JK, et al.BMC Cancer. 2010 Jun 9;10:268. doi: 10.1186/1471-2407-10-268.BMC Cancer. 2010.PMID:20529377Free PMC article.
- Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance.Liu C, Cai Z, Jin G, Peng D, Pan BS, Zhang X, Han F, Xu X, Lin HK.Liu C, et al.Cell Discov. 2018 Oct 2;4:54. doi: 10.1038/s41421-018-0054-x. eCollection 2018.Cell Discov. 2018.PMID:30302273Free PMC article.
- NK cells control breast cancer and related cancer stem cell hematological spread.Tallerico R, Conti L, Lanzardo S, Sottile R, Garofalo C, Wagner AK, Johansson MH, Cristiani CM, Kärre K, Carbone E, Cavallo F.Tallerico R, et al.Oncoimmunology. 2017 Feb 23;6(3):e1284718. doi: 10.1080/2162402X.2017.1284718. eCollection 2017.Oncoimmunology. 2017.PMID:28405511Free PMC article.
- Expression level comparison of marker genes related to early embryonic development and tumor growth.Cai QC, Li DL, Zhang Y, Liu YY, Fang P, Zheng SQ, Zhang YY, Yang YK, Hou C, Gao CW, Zhu QS, Cao CH.Cai QC, et al.Oncol Lett. 2022 Oct 26;24(6):444. doi: 10.3892/ol.2022.13564. eCollection 2022 Dec.Oncol Lett. 2022.PMID:36420077Free PMC article.
Publication types
MeSH terms
Personal name as subject
- Actions
- Actions