receptor-type tyrosine-protein phosphatase eta isoform 1 precursor [Homo sapiens]

NCBI Reference Sequence: NP_002834.3

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• Crystal structure of the PTPRJ inactivating mutant C1239S
  PDB: 2NZ6

  Source: Homo sapiens

  Method: X-ray Diffraction

  Resolution: 2.3 Å

• PTPRJ is downregulated in cervical squamous cell carcinoma.[J Genet. 2022]
  PTPRJ is downregulated in cervical squamous cell carcinoma.

  Roychowdhury A, Basu M, Pal D, Dutta P, Samadder S, Mondal R, Roy AK, Roychoudhury S, Panda CK.J Genet. 2022; 101.
• The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling.[Cancer Rep (Hoboken). 2022]
  The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling.

  He L, Takahashi K, Pasic L, Narui C, Ellinger P, Grundmann M, Takahashi T.Cancer Rep (Hoboken). 2022 Sep; 5(9):e1566. Epub 2021 Nov 17.
• Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.[J Neurol Sci. 2020]
  Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.

  Waldt N, Scharnetzki D, Kesseler C, Kirches E, Stroscher N, Böhmer FD, Mawrin C.J Neurol Sci. 2020 Jan 15; 408:116553. Epub 2019 Nov 9.

• RefSeq genomic sequence
  See the genomic reference sequence for the PTPRJ gene (NG_012209.1).
• RefSeq mRNA
  See reference mRNA sequence for the PTPRJ gene (NM_002843.4).
• RefSeq protein isoforms
  See 6 reference sequence protein isoforms for the PTPRJ gene.

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that...
  Also Known As: CD148, DEP1, HPTP eta, ...

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• NP_002834[Domain Mapping of Disease Mut...]
  NP_002834

  Domain Mapping of Disease Mutations
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