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Annals of the Rheumatic Diseases logo

Pharmacogenetics in the rheumatic diseases

B Cronstein
PMCID: PMC1766779  PMID:15479867

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Figure 1.

Figure 1

 Metabolism of azathioprine. MP, mercaptopurine; TPMT, thiopurine methyl transferase; XO, xanthine oxidase.

Figure 2.

Figure 2

 Methotrexate and cellular metabolism. 5-CH3-THF, 5-methyl-tetrahydrofolate; AICAR, aminoimidazolecarboxamidoribonucleotide; DHFR, dihydrofolate reductase; dTMP, deoxythymidine monophosphate; dUMP, deoxyutidine monophosphate; FAICAR, formyl aminoimidazolecarboxamidoribonucleotide; FPGS, folylpolyglutamate synthase; IMP, inosine monophosphate; MTHFR, methylene tetrahydrofolate reductase; MTX, methotrexate; MTXglu, methotrexate polyglutamate; RFC1, reduced folate carrier 1; THF, tetrahydrofolate; TS, thymidylate synthase.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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