PREDICTED: Mus musculus MAP/microtubule affinity regulating kinase 2 (Mark2), transcript variant X21, mRNA

NCBI Reference Sequence: XM_036161427.1

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• Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2.[FASEB J. 2024]
  Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2.

  Caiola HO, Wu Q, Li J, Wang XF, Soni S, Monahan K, Wagner GC, Pang ZP, Zhang H.FASEB J. 2024 Oct 31; 38(20):e70124.
• MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway.[Am J Hum Genet. 2024]
  MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway.

  Gong M, Li J, Qin Z, Machado Bressan Wilke MV, Liu Y, Li Q, Liu H, Liang C, Morales-Rosado JA, Cohen ASA, et al.Am J Hum Genet. 2024 Nov 7; 111(11):2392-2410. Epub 2024 Oct 16.
• MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.[Proc Natl Acad Sci U S A. 2024]
  MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.

  Han Y, Li M, Zhao B, Wang H, Liu Y, Liu Z, Xu J, Yang R.Proc Natl Acad Sci U S A. 2024 May 14; 121(20):e2316266121. Epub 2024 May 6.

• RefSeq alternative splicing
  See 27 reference mRNA sequence splice variants for the Mark2 gene.
• RefSeq protein product
  See the reference protein sequence for serine/threonine-protein kinase MARK2 isoform X19 (XP_036017320.1).

• Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and tau protein binding activity. Pre...
  Also Known As: EMK-1, Emk, Par-1, Par-1b

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