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SUDDEN INFANT DEATH SYNDROME(SIDS)

MedGen UID:: 52548
•Concept ID:: C0038644
•: Disease or Syndrome

Synonyms:	CAV3-Related Sudden Infant Death Syndrome; SIDS; Sudden Infant Death
SNOMED CT:	SIDS - sudden infant death syndrome (51178009); Sudden infant death syndrome (51178009); Unexpected sudden death of infant (51178009); Crib death (51178009); Cot death (51178009)

Gene (location): Gene(s) directly associated with this condition or phenotype.	SCN5A (3p22.2)

OMIM®:	272120

Definition

Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy without identification of a specific cause of death (Mage and Donner, 2004). Weese-Mayer et al. (2007) provided a detailed review of genetic factors that have been implicated in SIDS. The authors concluded that SIDS represents more than 1 entity and has a heterogeneous etiology most likely involving several different genetically controlled metabolic pathways. [fromOMIM]

Clinical features

From HPO

Sudden death

MedGen UID:: 8257
•Concept ID:: C0011071
•: Pathologic Function

Rapid and unexpected death.

See:Feature record | Search on this feature

Apneic episodes in infancy

MedGen UID:: 814310
•Concept ID:: C3807980
•: Finding

Recurrent episodes of apnea occurring during infancy.

See:Feature record | Search on this feature

Malignant hyperthermia

MedGen UID:: 1830388
•Concept ID:: C5779784
•: Pathologic Function

Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise.

See:Feature record | Search on this feature

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Abnormality of metabolism/homeostasis
- Malignant hyperthermia
Abnormality of the respiratory system
- Apneic episodes in infancy
Constitutional symptom
- Sudden death

Term Hierarchy

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSUDDEN INFANT DEATH SYNDROME

Infant death
- SUDDEN INFANT DEATH SYNDROME

Professional guidelines

PubMed

How to use genetic testing after sudden infant death syndrome.

Bryson LJ,Joss S
Arch Dis Child Educ Pract Ed2022 Oct;107(5):383-385.Epub 2021 Jan 12doi: 10.1136/archdischild-2020-320835.PMID:33436404

Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: US Preventive Services Task Force Recommendation Statement.

US Preventive Services Task Force,Krist AH,Davidson KW,Mangione CM,Barry MJ,Cabana M,Caughey AB,Donahue K,Doubeni CA,Epling JW Jr,Kubik M,Ogedegbe G,Pbert L,Silverstein M,Simon MA,Tseng CW,Wong JB
JAMA2021 Jan 19;325(3):265-279.doi: 10.1001/jama.2020.25019.PMID:33464343

Sudden infant death syndrome.

Gelfer P,Tatum M
J Pediatr Health Care2014 Sep-Oct;28(5):470-4.Epub 2014 Jun 16doi: 10.1016/j.pedhc.2014.04.007.PMID:24944089

See all (90)

These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See theFAQ for details.

These guidelines are manually curated by the MedGen team to supplement articles available in PubMed. See theFAQ for details.

Recent clinical studies

Etiology

Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions.

Fraile-Martinez O,García-Montero C,Díez SC,Bravo C,Quintana-Coronado MG,Lopez-Gonzalez L,Barrena-Blázquez S,García-Honduvilla N,De León-Luis JA,Rodriguez-Martín S,Saez MA,Alvarez-Mon M,Diaz-Pedrero R,Ortega MA
Int J Med Sci2024;21(5):848-861.Epub 2024 Mar 25doi: 10.7150/ijms.89490.PMID:38617004 Free PMC Article

Inflammation in sudden infant death syndrome.

MacFarlane PM
Pediatr Res2024 Mar;95(4):885-886.Epub 2023 Dec 15doi: 10.1038/s41390-023-02966-8.PMID:38097722

Sudden infant death syndrome prevention.

Jullien S
BMC Pediatr2021 Sep 8;21(Suppl 1):320.doi: 10.1186/s12887-021-02536-z.PMID:34496779 Free PMC Article

Parent-infant co-sleeping and the implications for sudden infant death syndrome.

Straw J,Jones P
Nurs Child Young People2017 Dec 5;29(10):24-29.doi: 10.7748/ncyp.2017.e945.PMID:29206359

Sudden infant death syndrome.

Nagler J
Curr Opin Pediatr2002 Apr;14(2):247-50.doi: 10.1097/00008480-200204000-00018.PMID:11981299

See all (2737)

Diagnosis

Positional Plagiocephaly and Craniosynostosis.

Santiago GS,Santiago CN,Chwa ES,Purnell CA
Pediatr Ann2023 Jan;52(1):e10-e17.Epub 2023 Jan 1doi: 10.3928/19382359-20221114-03.PMID:36625797

How to use genetic testing after sudden infant death syndrome.

Bryson LJ,Joss S
Arch Dis Child Educ Pract Ed2022 Oct;107(5):383-385.Epub 2021 Jan 12doi: 10.1136/archdischild-2020-320835.PMID:33436404

SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment.

Moon RY;TASK FORCE ON SUDDEN INFANT DEATH SYNDROME
Pediatrics2016 Nov;138(5)doi: 10.1542/peds.2016-2940.PMID:27940805

Sudden infant death syndrome.

Moon RY,Fu LY
Pediatr Rev2007 Jun;28(6):209-14.doi: 10.1542/pir.28-6-209.PMID:17545332

Infant botulism.

Polin RA,Brown LW
Pediatr Clin North Am1979 May;26(2):345-54.doi: 10.1016/s0031-3955(16)33710-5.PMID:379778

See all (925)

Therapy

Burden of disease attributable to second-hand smoke exposure: A systematic review.

Carreras G,Lugo A,Gallus S,Cortini B,Fernández E,López MJ,Soriano JB,López-Nicolás A,Semple S,Gorini G;TackSHS Project Investigators
Prev Med2019 Dec;129:105833.Epub 2019 Sep 7doi: 10.1016/j.ypmed.2019.105833.PMID:31505203

Parent-infant co-sleeping and the implications for sudden infant death syndrome.

Straw J,Jones P
Nurs Child Young People2017 Dec 5;29(10):24-29.doi: 10.7748/ncyp.2017.e945.PMID:29206359

Sudden infant death syndrome and advice for safe sleeping.

Horne RS,Hauck FR,Moon RY
BMJ2015 Apr 28;350:h1989.doi: 10.1136/bmj.h1989.PMID:25921604

Sudden infant death syndrome.

Moon RY,Fu LY
Pediatr Rev2007 Jun;28(6):209-14.doi: 10.1542/pir.28-6-209.PMID:17545332

Infant botulism.

Polin RA,Brown LW
Pediatr Clin North Am1979 May;26(2):345-54.doi: 10.1016/s0031-3955(16)33710-5.PMID:379778

See all (808)

Prognosis

Pathobiology of cardiovascular diseases: an update.

Buja LM,Ottaviani G,Mitchell RN
Cardiovasc Pathol2019 Sep-Oct;42:44-53.Epub 2019 Jun 14doi: 10.1016/j.carpath.2019.06.002.PMID:31255975

Sudden infant death syndrome and advice for safe sleeping.

Horne RS,Hauck FR,Moon RY
BMJ2015 Apr 28;350:h1989.doi: 10.1136/bmj.h1989.PMID:25921604

Sudden infant death syndrome.

Creery D,Mikrogianakis A
Am Fam Physician2003 Oct 1;68(7):1375-6.PMID:14567492

Sudden infant death syndrome and subsequent siblings.

Carbone MT
N J Med1992 Sep;89(9):684-6.PMID:1436732

Sudden-infant-death syndrome.

Meyer RJ
N Engl J Med1973 Feb 8;288(6):324.doi: 10.1056/NEJM197302082880621.PMID:4682681

See all (1061)

Clinical prediction guides

Neonatal respiratory inhibition.

Minowa H
J Matern Fetal Neonatal Med2022 Dec;35(25):7132-7138.Epub 2021 Jun 28doi: 10.1080/14767058.2021.1944094.PMID:34182876

Sudden infant death syndrome prevention.

Jullien S
BMC Pediatr2021 Sep 8;21(Suppl 1):320.doi: 10.1186/s12887-021-02536-z.PMID:34496779 Free PMC Article

Sids.

Hauck FR,Tanabe KO
BMJ Clin Evid2009 Jun 5;2009PMID:21726486 Free PMC Article

Sudden infant death syndrome: a critical review of approaches to research.

Goldwater PN
Arch Dis Child2003 Dec;88(12):1095-100.doi: 10.1136/adc.88.12.1095.PMID:14670779 Free PMC Article

Prolonged apnea and the sudden infant death syndrome: clinical and laboratory observations.

Steinschneider A
Pediatrics1972 Oct;50(4):646-54.PMID:4342142

See all (834)

Recent systematic reviews

Positioning for acute respiratory distress in hospitalised infants and children.

Bhandari AP,Nnate DA,Vasanthan L,Konstantinidis M,Thompson J
Cochrane Database Syst Rev2022 Jun 6;6(6):CD003645.doi: 10.1002/14651858.CD003645.pub4.PMID:35661343 Free PMC Article

Burden of disease attributable to second-hand smoke exposure: A systematic review.

Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review.

Banderali G,Martelli A,Landi M,Moretti F,Betti F,Radaelli G,Lassandro C,Verduci E
J Transl Med2015 Oct 15;13:327.doi: 10.1186/s12967-015-0690-y.PMID:26472248 Free PMC Article

Sids.

Hauck FR,Tanabe KO
BMJ Clin Evid2009 Jun 5;2009PMID:21726486 Free PMC Article

Swaddling: a systematic review.

van Sleuwen BE,Engelberts AC,Boere-Boonekamp MM,Kuis W,Schulpen TW,L'Hoir MP
Pediatrics2007 Oct;120(4):e1097-106.doi: 10.1542/peds.2006-2083.PMID:17908730

See all (46)

Supplemental Content

Genetic Testing Registry

Clinical resources

Practice guidelines

PubMed
See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.
Bookshelf
See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.

Molecular resources

Consumer resources

Reviews

Related information

ClinVar
Related medical variations
Gene
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GTR
Related information in GTR
GTR(Clinical)
Clinical tests in GTR
MeSH
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OMIM
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OMIM(Genes)
OMIM records containing genes associated with phenotypes registered in MedGen
PMC Articles
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PubMed
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PubMed (OMIM)
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