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Constitutional symptom

MedGen UID:: 3593
•Concept ID:: C0009812
•: Sign or Symptom

Synonyms:	Constitutional Finding; Constitutional Symptom

HPO:	HP:0025142

Definition

A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual. [fromHPO]

Term Hierarchy

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVConstitutional symptom

Phenotypic abnormality
- Constitutional symptom

Professional guidelines

PubMed

Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.

Padrnos L,Mesa R
Expert Opin Investig Drugs2020 Aug;29(8):809-817.Epub 2020 Jul 16doi: 10.1080/13543784.2020.1782886.PMID:32552220 Free PMC Article

Impact of influenza treatment with oseltamivir on health, sleep and daily activities of otherwise healthy adults and adolescents.

Bettis R,Iacuzio D,Jung T,Fuchs R,Aultman R,Gyldmark M
Clin Drug Investig2006;26(6):329-40.doi: 10.2165/00044011-200626060-00004.PMID:17163267

See all (2)

These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See theFAQ for details.

These guidelines are manually curated by the MedGen team to supplement articles available in PubMed. See theFAQ for details.

Recent clinical studies

Etiology

Fever in systemic lupus erythematosus: associated clinical features and genetic factors.

Olivieri G,Ceccarelli F,Perricone C,Ciccacci C,Pirone C,Natalucci F,Spinelli FR,Alessandri C,Borgiani P,Conti F
Clin Exp Rheumatol2022 Nov;40(11):2141-2146.Epub 2022 Mar 23doi: 10.55563/clinexprheumatol/7x37pf.PMID:35349414

Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.

Pata D,Buonsenso D,Frasca G,Lazzareschi I,Salerno G,Turriziani Colonna A,Mariotti P,Valentini P
Pediatr Infect Dis J2021 Jun 1;40(6):513-517.doi: 10.1097/INF.0000000000003070.PMID:33902074

Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.

Padrnos L,Mesa R
Expert Opin Investig Drugs2020 Aug;29(8):809-817.Epub 2020 Jul 16doi: 10.1080/13543784.2020.1782886.PMID:32552220 Free PMC Article

Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.

Seynaeve D,Augusseau-Rivière B,Couturier P,Morel-Baccard C,Landelle C,Bosson JL,Gavazzi G,Mallaret MR
J Am Med Dir Assoc2020 Jan;21(1):104-109.e1.Epub 2019 May 14doi: 10.1016/j.jamda.2019.03.015.PMID:31101588 Free PMC Article

Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.

Alcabes P,Schoenbaum EE,Klein RS
Am J Epidemiol1993 May 1;137(9):989-1000.doi: 10.1093/oxfordjournals.aje.a116771.PMID:8100395

See all (17)

Diagnosis

Fever in systemic lupus erythematosus: associated clinical features and genetic factors.

Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.

Sung J,Choudry N,Bachour R
Epidemiol Infect2020 Nov 13;148:e273.doi: 10.1017/S0950268820002769.PMID:33183384 Free PMC Article

Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.

Impetigo herpetiformis in a primigravida: successful treatment with etretinate.

Bukhari IA
J Drugs Dermatol2004 Jul-Aug;3(4):449-51.PMID:15303793

Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.

Alcabes P,Schoenbaum EE,Klein RS
Am J Epidemiol1993 May 1;137(9):989-1000.doi: 10.1093/oxfordjournals.aje.a116771.PMID:8100395

See all (15)

Therapy

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.

Le Gall-Ianotto C,Ficheux AS,Lippert E,Herbreteau L,Rio L,Pan-Petesch B,Misery L,Ianotto JC
J Eur Acad Dermatol Venereol2023 Jun;37(6):1175-1183.Epub 2023 Mar 9doi: 10.1111/jdv.18990.PMID:36808754

Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.

Padrnos L,Mesa R
Expert Opin Investig Drugs2020 Aug;29(8):809-817.Epub 2020 Jul 16doi: 10.1080/13543784.2020.1782886.PMID:32552220 Free PMC Article

Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial.

Haffizulla J,Hartman A,Hoppers M,Resnick H,Samudrala S,Ginocchio C,Bardin M,Rossignol JF;US Nitazoxanide Influenza Clinical Study Group
Lancet Infect Dis2014 Jul;14(7):609-18.Epub 2014 May 19doi: 10.1016/S1473-3099(14)70717-0.PMID:24852376 Free PMC Article

Impetigo herpetiformis in a primigravida: successful treatment with etretinate.

Bukhari IA
J Drugs Dermatol2004 Jul-Aug;3(4):449-51.PMID:15303793

Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.

Alcabes P,Schoenbaum EE,Klein RS
Am J Epidemiol1993 May 1;137(9):989-1000.doi: 10.1093/oxfordjournals.aje.a116771.PMID:8100395

See all (11)

Prognosis

Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.

Pata D,Buonsenso D,Frasca G,Lazzareschi I,Salerno G,Turriziani Colonna A,Mariotti P,Valentini P
Pediatr Infect Dis J2021 Jun 1;40(6):513-517.doi: 10.1097/INF.0000000000003070.PMID:33902074

Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.

Sung J,Choudry N,Bachour R
Epidemiol Infect2020 Nov 13;148:e273.doi: 10.1017/S0950268820002769.PMID:33183384 Free PMC Article

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants.

Mulazzani E,Wagner D,Havla J,Schlüter M,Meinl I,Gerdes LA,Kümpfel T
J Neuroinflammation2020 Jun 20;17(1):196.doi: 10.1186/s12974-020-01867-5.PMID:32563262 Free PMC Article

Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.

McLornan DP,Malpassuti V,Lippinkhof-Kozijn A,Potter V,Beelen D,Bunjes D,Sengeloev H,Radujkovic A,Passweg J,Chalandon Y,Kröger N,Wulf GG,Johansson JE,Ciceri F,Bornhäuser M,Holler E,Guffroy B,Martin S,Neubauer A,Gramatski M,Robin M,Iacobelli S,Hayden P,Hernández Boluda JC,Czerw T,Yakoub-Agha I
Br J Haematol2020 Aug;190(3):437-441.Epub 2020 Feb 28doi: 10.1111/bjh.16537.PMID:32108327

Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.

Alcabes P,Schoenbaum EE,Klein RS
Am J Epidemiol1993 May 1;137(9):989-1000.doi: 10.1093/oxfordjournals.aje.a116771.PMID:8100395

See all (9)

Clinical prediction guides

Clinical and Radiological Presentation of Patients with Smear Positive Pulmonary Tuberculosis.

Noor SM,Ahmad MM,Anwar KMR,Chowdhury MF,Sultana M,Kader MA,Khan MAS
Mymensingh Med J2024 Oct;33(4):1211-1218.PMID:39351745

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.

Le Gall-Ianotto C,Ficheux AS,Lippert E,Herbreteau L,Rio L,Pan-Petesch B,Misery L,Ianotto JC
J Eur Acad Dermatol Venereol2023 Jun;37(6):1175-1183.Epub 2023 Mar 9doi: 10.1111/jdv.18990.PMID:36808754

Fever in systemic lupus erythematosus: associated clinical features and genetic factors.

Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.

Sung J,Choudry N,Bachour R
Epidemiol Infect2020 Nov 13;148:e273.doi: 10.1017/S0950268820002769.PMID:33183384 Free PMC Article

Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.

Alcabes P,Schoenbaum EE,Klein RS
Am J Epidemiol1993 May 1;137(9):989-1000.doi: 10.1093/oxfordjournals.aje.a116771.PMID:8100395

See all (14)

Supplemental Content

Clinical resources

ClinicalTrials.gov

Practice guidelines

PubMed
See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.
Bookshelf
See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.