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Pain, Intractable

MedGen UID:: 14574
•Concept ID:: C0030200
•: Sign or Symptom

Synonyms:

Intractable Pain; Intractable Pains; Pain, Refractory; Pains, Intractable; Pains, Refractory; Refractory Pain; Refractory Pains

Definition

Persistent pain that is refractory to some or all forms of treatment. [fromMeSH]

Term Hierarchy

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPain, Intractable

Phenotypic abnormality
- Constitutional symptom
  - Pain
    - Pain, Intractable

Professional guidelines

PubMed

Current Understanding of Phantom Pain and its Treatment.

Culp CJ,Abdi S
Pain Physician2022 Oct;25(7):E941-E957.PMID:36288580

Progress in the treatment of diabetic peripheral neuropathy.

Yang K,Wang Y,Li YW,Chen YG,Xing N,Lin HB,Zhou P,Yu XP
Biomed Pharmacother2022 Apr;148:112717.Epub 2022 Feb 19doi: 10.1016/j.biopha.2022.112717.PMID:35193039

Scheuermann's Kyphosis: Diagnosis, Management, and Selecting Fusion Levels.

Sardar ZM,Ames RJ,Lenke L
J Am Acad Orthop Surg2019 May 15;27(10):e462-e472.doi: 10.5435/JAAOS-D-17-00748.PMID:30407981

See all (309)

These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See theFAQ for details.

These guidelines are manually curated by the MedGen team to supplement articles available in PubMed. See theFAQ for details.

Recent clinical studies

Etiology

Cancer pain and current theory for pain control.

Kahan B
Phys Med Rehabil Clin N Am2014 May;25(2):439-56.doi: 10.1016/j.pmr.2014.01.013.PMID:24787342

Medullary sponge kidney.

Gambaro G,Danza FM,Fabris A
Curr Opin Nephrol Hypertens2013 Jul;22(4):421-6.doi: 10.1097/MNH.0b013e3283622b86.PMID:23680648

Oral mucositis.

Raber-Durlacher JE,Elad S,Barasch A
Oral Oncol2010 Jun;46(6):452-6.Epub 2010 Apr 18doi: 10.1016/j.oraloncology.2010.03.012.PMID:20403721

Palliative therapy for pancreatic/biliary cancer.

House MG,Choti MA
Surg Oncol Clin N Am2004 Jul;13(3):491-503, ix.doi: 10.1016/j.soc.2004.04.004.PMID:15236731

Coccygeal retroversion.

Dennell LV,Nathan S
Spine (Phila Pa 1976)2004 Jun 15;29(12):E256-7.doi: 10.1097/01.brs.0000127194.97062.17.PMID:15187650

See all (1414)

Diagnosis

Interventional Cryoneurolysis: An Illustrative Approach.

Prologo JD,Edalat F,Moussa M
Tech Vasc Interv Radiol2020 Dec;23(4):100698.Epub 2020 Oct 15doi: 10.1016/j.tvir.2020.100698.PMID:33308581

Only in Silence.

Eison D
Hastings Cent Rep2018 May;48(3):3-4.doi: 10.1002/hast.845.PMID:29806890

Intractable pain.

Viswanathan A,Burchiel KJ
Neurosurg Focus2013 Sep;35(3):Introduction.doi: 10.3171/2013.7.FOCUS13277.PMID:23991823

Medullary sponge kidney.

Gambaro G,Danza FM,Fabris A
Curr Opin Nephrol Hypertens2013 Jul;22(4):421-6.doi: 10.1097/MNH.0b013e3283622b86.PMID:23680648

Central post-stroke pain: clinical characteristics, pathophysiology, and management.

Klit H,Finnerup NB,Jensen TS
Lancet Neurol2009 Sep;8(9):857-68.doi: 10.1016/S1474-4422(09)70176-0.PMID:19679277

See all (897)

Therapy

Defining refractory rheumatoid arthritis.

Buch MH
Ann Rheum Dis2018 Jul;77(7):966-969.Epub 2018 Mar 27doi: 10.1136/annrheumdis-2017-212862.PMID:29588276

Central neuromodulation for refractory pain.

Moore NZ,Lempka SF,Machado A
Neurosurg Clin N Am2014 Jan;25(1):77-83.Epub 2013 Oct 10doi: 10.1016/j.nec.2013.08.011.PMID:24262901 Free PMC Article

Radiofrequency procedures.

Racz GB,Ruiz-Lopez R
Pain Pract2006 Mar;6(1):46-50.doi: 10.1111/j.1533-2500.2006.00058.x.PMID:17309709

Cancer pain.

Bruera E,Kim HN
JAMA2003 Nov 12;290(18):2476-9.doi: 10.1001/jama.290.18.2476.PMID:14612485

Defining the clinically important difference in pain outcome measures.

Farrar JT,Portenoy RK,Berlin JA,Kinman JL,Strom BL
Pain2000 Dec 1;88(3):287-294.doi: 10.1016/S0304-3959(00)00339-0.PMID:11068116

See all (2427)

Prognosis

Defining refractory rheumatoid arthritis.

Buch MH
Ann Rheum Dis2018 Jul;77(7):966-969.Epub 2018 Mar 27doi: 10.1136/annrheumdis-2017-212862.PMID:29588276

Side effects of commonly prescribed analgesic medications.

Carter GT,Duong V,Ho S,Ngo KC,Greer CL,Weeks DL
Phys Med Rehabil Clin N Am2014 May;25(2):457-70.doi: 10.1016/j.pmr.2014.01.007.PMID:24787343

Cancer pain and current theory for pain control.

Kahan B
Phys Med Rehabil Clin N Am2014 May;25(2):439-56.doi: 10.1016/j.pmr.2014.01.013.PMID:24787342

Medullary sponge kidney.

Gambaro G,Danza FM,Fabris A
Curr Opin Nephrol Hypertens2013 Jul;22(4):421-6.doi: 10.1097/MNH.0b013e3283622b86.PMID:23680648

Pathophysiology of joint pain.

Perrot S,Guilbaud G
Rev Rhum Engl Ed1996 Jul-Sep;63(7-8):485-92.PMID:8896062

See all (747)

Clinical prediction guides

New insights into perineural invasion of pancreatic cancer: More than pain.

Liang D,Shi S,Xu J,Zhang B,Qin Y,Ji S,Xu W,Liu J,Liu L,Liu C,Long J,Ni Q,Yu X
Biochim Biophys Acta2016 Apr;1865(2):111-22.Epub 2016 Jan 12doi: 10.1016/j.bbcan.2016.01.002.PMID:26794395

Medullary sponge kidney.

Gambaro G,Danza FM,Fabris A
Curr Opin Nephrol Hypertens2013 Jul;22(4):421-6.doi: 10.1097/MNH.0b013e3283622b86.PMID:23680648

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.

Johnson JR,Burnell-Nugent M,Lossignol D,Ganae-Motan ED,Potts R,Fallon MT
J Pain Symptom Manage2010 Feb;39(2):167-79.Epub 2009 Nov 5doi: 10.1016/j.jpainsymman.2009.06.008.PMID:19896326

Transdermal matrix fentanyl membrane patch (matrifen): in severe cancer-related chronic pain.

Hair PI,Keating GM,McKeage K
Drugs2008;68(14):2001-9.doi: 10.2165/00003495-200868140-00005.PMID:18778121

Intractable trigeminal neuralgia.

Watts PG
J R Soc Med1987 Sep;80(9):561-2.doi: 10.1177/014107688708000909.PMID:3681871 Free PMC Article

See all (966)

Recent systematic reviews

Medial thalamotomy using stereotactic radiosurgery for intractable pain: a systematic review.

Franzini A,Rossini Z,Moosa S,Tropeano MP,Milani D,Attuati L,Clerici E,Navarria P,Pessina F,Picozzi P
Neurosurg Rev2022 Feb;45(1):71-80.Epub 2021 May 12doi: 10.1007/s10143-021-01561-x.PMID:33978923

Chronic and Refractory Pain: A Systematic Review of Pharmacologic Management in Oncology .

Brant JM,Keller L,McLeod K,Yeh C,Eaton LH
Clin J Oncol Nurs2017 Jun 1;21(3 Suppl):31-53.doi: 10.1188/17.CJON.S3.31-53.PMID:28524906

African Americans' Perceptions of Pain and Pain Management: A Systematic Review.

Booker SQ
J Transcult Nurs2016 Jan;27(1):73-80.Epub 2014 May 19doi: 10.1177/1043659614526250.PMID:24841472

WITHDRAWN: Radiotherapy for the palliation of painful bone metastases.

McQuay HJ,Collins SL,Carroll D,Moore RA,Derry S
Cochrane Database Syst Rev2013 Nov 22;2013(11):CD001793.doi: 10.1002/14651858.CD001793.pub2.PMID:24271498 Free PMC Article

WITHDRAWN: Comparative efficacy of epidural, subarachnoid, and intracerebroventricular opioids in patients with pain due to cancer.

Ballantyne JC,Carwood C,Gupta A,Bennett MI,Simpson KH,Dhandapani K,Lynch L,Baranidharan G
Cochrane Database Syst Rev2013 Oct 25;2013(10):CD005178.doi: 10.1002/14651858.CD005178.pub2.PMID:24163272 Free PMC Article

See all (54)

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Practice guidelines

PubMed
See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.
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See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.