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Allodynia

MedGen UID:: 105350
•Concept ID:: C0458247
•: Finding; Sign or Symptom

Synonym:	Allodynias
SNOMED CT:	Allodynia (247404004); Painful response to non-painful stimulus (247404004)

HPO:	HP:0012533

Definition

Pain due to a stimulus that does not normally provoke pain. [fromHPO]

Term Hierarchy

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAllodynia

Phenotypic abnormality
- Constitutional symptom
  - Pain
    - Allodynia

Conditions with this feature

Mitochondrial DNA depletion syndrome 1

MedGen UID:: 1631838
•Concept ID:: C4551995
•: Disease or Syndrome

Mitochondrial neurogastrointestinal encephalopathy (MNGIE) disease is characterized by progressive gastrointestinal dysmotility (manifesting as early satiety, nausea, dysphagia, gastroesophageal reflux, postprandial emesis, episodic abdominal pain and/or distention, and diarrhea); cachexia; ptosis/ophthalmoplegia or ophthalmoparesis; leukoencephalopathy; and demyelinating peripheral neuropathy (manifesting as paresthesias (tingling, numbness, and pain) and symmetric and distal weakness more prominently affecting the lower extremities). The order in which manifestations appear is unpredictable. Onset is usually between the first and fifth decades; in about 60% of individuals, symptoms begin before age 20 years.

See:Condition Record

Mitochondrial DNA depletion syndrome 1

Professional guidelines

PubMed

Cause and management of lipedema-associated pain.

Aksoy H,Karadag AS,Wollina U
Dermatol Ther2021 Jan;34(1):e14364.Epub 2020 Oct 12doi: 10.1111/dth.14364.PMID:33001552

Neuropathic Pain: From Mechanisms to Treatment.

Finnerup NB,Kuner R,Jensen TS
Physiol Rev2021 Jan 1;101(1):259-301.Epub 2020 Jun 25doi: 10.1152/physrev.00045.2019.PMID:32584191

Central sensitization: implications for the diagnosis and treatment of pain.

Woolf CJ
Pain2011 Mar;152(3 Suppl):S2-S15.Epub 2010 Oct 18doi: 10.1016/j.pain.2010.09.030.PMID:20961685 Free PMC Article

See all (162)

These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See theFAQ for details.

These guidelines are manually curated by the MedGen team to supplement articles available in PubMed. See theFAQ for details.

Recent clinical studies

Etiology

Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.

Kaplan CM,Kelleher E,Irani A,Schrepf A,Clauw DJ,Harte SE
Nat Rev Neurol2024 Jun;20(6):347-363.Epub 2024 May 16doi: 10.1038/s41582-024-00966-8.PMID:38755449

Medication "underuse" headache.

Rattanawong W,Rapoport A,Srikiatkhachorn A
Cephalalgia2024 Apr;44(4):3331024241245658.doi: 10.1177/03331024241245658.PMID:38613233

Variations in herpes zoster manifestation.

Wollina U
Indian J Med Res2017 Mar;145(3):294-298.doi: 10.4103/ijmr.IJMR_1622_16.PMID:28749391 Free PMC Article

Pathophysiology of migraine chronification.

Aguggia M,Saracco MG
Neurol Sci2010 Jun;31 Suppl 1:S15-7.doi: 10.1007/s10072-010-0264-y.PMID:20464576

Pudendal neuralgia.

Turner ML,Marinoff SC
Am J Obstet Gynecol1991 Oct;165(4 Pt 2):1233-6.doi: 10.1016/s0002-9378(12)90733-4.PMID:1951579

See all (943)

Diagnosis

Pathophysiology and Therapy of Associated Features of Migraine.

Villar-Martinez MD,Goadsby PJ
Cells2022 Sep 5;11(17)doi: 10.3390/cells11172767.PMID:36078174 Free PMC Article

The neuropathic pain: An overview of the current treatment and future therapeutic approaches.

Cavalli E,Mammana S,Nicoletti F,Bramanti P,Mazzon E
Int J Immunopathol Pharmacol2019 Jan-Dec;33:2058738419838383.doi: 10.1177/2058738419838383.PMID:30900486 Free PMC Article

Migraine: multiple processes, complex pathophysiology.

Burstein R,Noseda R,Borsook D
J Neurosci2015 Apr 29;35(17):6619-29.doi: 10.1523/JNEUROSCI.0373-15.2015.PMID:25926442 Free PMC Article

Neuropathic pain.

Basić-Kes V,Zavoreo I,Bosnar-Puretić M,Ivanković M,Bitunjac M,Govori V,Demarin V
Acta Clin Croat2009 Sep;48(3):359-65.PMID:20055264

Nummular headache.

Grosberg BM,Solomon S,Lipton RB
Curr Pain Headache Rep2007 Aug;11(4):310-2.doi: 10.1007/s11916-007-0209-1.PMID:17686396

See all (1059)

Therapy

The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4.

White JPM,Cibelli M,Nagy I,Nilius B,McGeown JG
Rev Physiol Biochem Pharmacol2023;186:57-93.doi: 10.1007/112_2022_75.PMID:36378366

Interventional Treatments for Postherpetic Neuralgia: A Systematic Review.

Lin CS,Lin YC,Lao HC,Chen CC
Pain Physician2019 May;22(3):209-228.PMID:31151330

The neuropathic pain: An overview of the current treatment and future therapeutic approaches.

Cavalli E,Mammana S,Nicoletti F,Bramanti P,Mazzon E
Int J Immunopathol Pharmacol2019 Jan-Dec;33:2058738419838383.doi: 10.1177/2058738419838383.PMID:30900486 Free PMC Article

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.

Ji RR,Nackley A,Huh Y,Terrando N,Maixner W
Anesthesiology2018 Aug;129(2):343-366.doi: 10.1097/ALN.0000000000002130.PMID:29462012 Free PMC Article

Quantitative sensory testing: a comprehensive protocol for clinical trials.

Rolke R,Magerl W,Campbell KA,Schalber C,Caspari S,Birklein F,Treede RD
Eur J Pain2006 Jan;10(1):77-88.doi: 10.1016/j.ejpain.2005.02.003.PMID:16291301

See all (1373)

Prognosis

GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.

Xie YK,Luo H,Zhang SX,Chen XY,Guo R,Qiu XY,Liu S,Wu H,Chen WB,Zhen XH,Ma Q,Tian JL,Li S,Chen X,Han Q,Duan S,Shen C,Yang F,Xu ZZ
Sci Transl Med2022 Apr 6;14(639):eabh2557.doi: 10.1126/scitranslmed.abh2557.PMID:35385340

Present status and future directions of intracanal medicaments.

Ordinola-Zapata R,Noblett WC,Perez-Ron A,Ye Z,Vera J
Int Endod J2022 May;55 Suppl 3(Suppl 3):613-636.Epub 2022 Apr 19doi: 10.1111/iej.13731.PMID:35322427 Free PMC Article

Complex Regional Pain Syndrome, Current Concepts and Treatment Options.

Urits I,Shen AH,Jones MR,Viswanath O,Kaye AD
Curr Pain Headache Rep2018 Feb 5;22(2):10.doi: 10.1007/s11916-018-0667-7.PMID:29404787

Pediatric complex regional pain syndrome: a review.

Weissmann R,Uziel Y
Pediatr Rheumatol Online J2016 Apr 29;14(1):29.doi: 10.1186/s12969-016-0090-8.PMID:27130211 Free PMC Article

Preclinical Assessment of Inflammatory Pain.

Muley MM,Krustev E,McDougall JJ
CNS Neurosci Ther2016 Feb;22(2):88-101.Epub 2015 Dec 10doi: 10.1111/cns.12486.PMID:26663896 Free PMC Article

See all (418)

Clinical prediction guides

Efficacy of galcanezumab in migraine central sensitization.

Danno D,Imai N,Kitamura S,Ishizaki K,Kikui S,Takeshima T
Sci Rep2024 Sep 18;14(1):21824.doi: 10.1038/s41598-024-72282-6.PMID:39294310 Free PMC Article

Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain.

Xie H,Li J,Lian N,Xie M,Wu M,Tang K,Kang Y,Lu P,Li T
EMBO Rep2023 Nov 6;24(11):e56958.Epub 2023 Sep 18doi: 10.15252/embr.202356958.PMID:37721527 Free PMC Article

Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination.

Ueda H
Mol Pain2008 Apr 1;4:11.doi: 10.1186/1744-8069-4-11.PMID:18377664 Free PMC Article

Preventing chronicity of migraine.

Fanciullacci M,De Cesaris F
J Headache Pain2005 Sep;6(4):331-3.doi: 10.1007/s10194-005-0224-8.PMID:16362703 Free PMC Article

Clinical features and pathophysiologic mechanisms of postherpetic neuralgia.

Nurmikko T
Neurology1995 Dec;45(12 Suppl 8):S54-5.doi: 10.1212/wnl.45.12_suppl_8.s54.PMID:8545022

See all (1010)

Recent systematic reviews

Clinical overlap between fibromyalgia and myalgic encephalomyelitis. A systematic review and meta-analysis.

Ramírez-Morales R,Bermúdez-Benítez E,Martínez-Martínez LA,Martínez-Lavín M
Autoimmun Rev2022 Aug;21(8):103129.Epub 2022 Jun 9doi: 10.1016/j.autrev.2022.103129.PMID:35690247

Interventional Treatments for Postherpetic Neuralgia: A Systematic Review.

Lin CS,Lin YC,Lao HC,Chen CC
Pain Physician2019 May;22(3):209-228.PMID:31151330

Pediatric Erythromelalgia and SCN9A Mutations: Systematic Review and Single-Center Case Series.

Arthur L,Keen K,Verriotis M,Peters J,Kelly A,Howard RF,Dib-Hajj SD,Waxman SG,Walker SM
J Pediatr2019 Mar;206:217-224.e9.Epub 2018 Nov 9doi: 10.1016/j.jpeds.2018.10.024.PMID:30416015

Central Pain Processing in Patients with Shoulder Pain: A Review of the Literature.

Noten S,Struyf F,Lluch E,D'Hoore M,Van Looveren E,Meeus M
Pain Pract2017 Feb;17(2):267-280.Epub 2016 Oct 14doi: 10.1111/papr.12502.PMID:27739242

Tramadol for neuropathic pain.

Hollingshead J,Dühmke RM,Cornblath DR
Cochrane Database Syst Rev2006 Jul 19;(3):CD003726.doi: 10.1002/14651858.CD003726.pub3.PMID:16856016

See all (45)

Supplemental Content

Clinical resources

ClinicalTrials.gov

Practice guidelines

PubMed
See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.
Bookshelf
See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See theFAQ for details.