Movatterモバイル変換

[0]ホーム
URL:

U.S. flag

An official website of the United States government

NIH NLM Logo
Log in

Gene

Genes and mapped phenotypes

Result Filters

  • Chromosome locations

    Clear
      more...

      Chromosome locations





  • Show additional filters

    • Additional filters

SIDEBAR
Format

Send to:

Choose Destination

IFNAR1 interferon alpha and beta receptor subunit 1 [Homo sapiens (human) ]

Gene ID: 3454, updated on 6-Feb-2026

In addition, your package will include a detailed data report in both TSV and JSONL formats.

Official Symbol
IFNAR1provided byHGNC
Official Full Name
interferon alpha and beta receptor subunit 1provided byHGNC
Primary source
HGNC:HGNC:5432
See related
Ensembl:ENSG00000142166MIM:107450;AllianceGenome:HGNC:5432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AVP; IFRC; IFNAR; IFNBR; CRF2-1; IMD106; IFN-R-1; IFN-alpha-REC
Summary
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in thyroid (RPKM 14.1), urinary bladder (RPKM 11.9) and 25 other tissuesSee more
Orthologs
all
Try the newGene page
Try the newTranscripts and proteins table
See IFNAR1 inGenome Data Viewer
Location:
21q22.11
Exon count:
12
Annotation releaseStatusAssemblyChrLocation
RS_2025_08currentGRCh38.p14 (GCF_000001405.40)21NC_000021.9 (33324395..33359864)
RS_2025_08currentT2T-CHM13v2.0 (GCF_009914755.1)21NC_060945.1 (31696639..31732109)
RS_2024_09previous assemblyGRCh37.p13 (GCF_000001405.25)21NC_000021.8 (34696700..34732170)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes

Go to nucleotide:GraphicsFASTAGenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject:PRJNA270632
  • Publication:PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. IFNAR1 expression level in Iranian multiple sclerosis patients treated with IFN-B. Sayad A,et al. Hum Antibodies, 2017. PMID 28282804
  2. Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization. Lutfalla G,et al. J Interferon Res, 1990 Oct. PMID 2148760
  3. Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection. Zhang Q,et al. Front Immunol, 2021. PMID 33746965,Free PMC Article
  4. Polymorphisms in the IFNAR1 gene in patients with chronic hepatitis C: outcome of combined IFN-alpha therapy. Tena-Tomás C,et al. Eur Cytokine Netw, 2007 Sep. PMID 17823081
  5. A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis. Gothe F,et al. Clin Infect Dis, 2022 Jan 7. PMID 33252644,Free PMC Article

See all (209) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping.
    Title: Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386∗ variant by tri-allelic genotyping.
  2. Association of IFNAR1 and IFNAR2 with COVID-19 severity.
    Title: Association of IFNAR1 and IFNAR2 with COVID-19 severity.
  3. CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.
    Title: CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.
  4. Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer.
    Title: Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer.
  5. Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.
    Title: Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.
  6. A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.
    Title: A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.
  7. Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
    Title: Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
  8. Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis.
    Title: Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis.
  9. Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.
    Title: Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.
  10. A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.
    Title: A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

DescriptionTests
Immunodeficiency 106, susceptibility to viral infections
MedGen:C5677009OMIM: 619935GeneReviews:Not available
Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Protein interactions

ProteinGeneInteractionPubs
Envelope surface glycoprotein gp120envSeven-day cultured macrophages treated with HIV-1 gp120 exhibit higher levels of type I IFN receptors than that of 1-day cultured monocytesPubMed

Go to the HIV-1, Human Interaction Database

    ProductsInteractantOther GeneComplexSourcePubsDescription

    Markers

    Gene OntologyProvided by GOA

    FunctionEvidence CodePubs
    enables JAK pathway signal transduction adaptor activity IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    enables JAK pathway signal transduction adaptor activity TAS
    Traceable Author Statement
    more info
    		PubMed 
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    		PubMed 
    enables interferon receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		PubMed 
    enables type I interferon binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 
    enables type I interferon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 
    enables type I interferon receptor activity IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    enables type I interferon receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 
    enables type I interferon receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		PubMed 
    ProcessEvidence CodePubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    		PubMed 
    involved_in cellular response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 
    involved_in cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    		PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 
    involved_in positive regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		PubMed 
    involved_in positive regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 
    involved_in regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		PubMed 
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 
    involved_in type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		PubMed 
    ComponentEvidence CodePubs
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		PubMed 
    Preferred Names
    interferon alpha/beta receptor 1
    Names
    IFN-alpha/beta receptor 1
    IFNalpha/beta receptor 1
    alpha-type antiviral protein
    beta-type antiviral protein
    cytokine receptor class-II member 1
    cytokine receptor family 2 member 1
    interferon (alpha, beta and omega) receptor 1
    interferon receptor 1
    interferon-alpha/beta receptor alpha chain
    interferon-beta receptor 1
    type I interferon receptor 1

    NEWTry the newTranscript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds.Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported inGenomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000629.3 →NP_000620.2  interferon alpha/beta receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_000620.2

      Status: REVIEWED

      Source sequence(s)
      AK123813, AP000298, BC021825, BC035603, BG116121, BG548299, BX537636, CA309858, J03171, R15745
      Consensus CDS
      CCDS13624.1
      UniProtKB/Swiss-Prot
      B2R6L9,B4DNT3,D3DSF0,P17181,Q53GW9,Q53H11,Q6PKD7,Q7M4L2,Q8WTZ2
      UniProtKB/TrEMBL
      C9J114
      Related
      ENSP00000270139.3,ENST00000270139.8
      Conserved Domains (2)summary
      pfam09294
      Location:126 →224
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:25 →114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001384498.1 →NP_001371427.1  interferon alpha/beta receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      UniProtKB/TrEMBL
      C9J114
      Conserved Domains (2)summary
      pfam09294
      Location:126 →224
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:20 →114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_001384499.1 →NP_001371428.1  interferon alpha/beta receptor 1 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      UniProtKB/TrEMBL
      A0A994J6V0
      Related
      ENSP00000515377.1,ENST00000703561.1
      Conserved Domains (2)summary
      pfam09294
      Location:126 →224
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:20 →114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. NM_001384500.1 →NP_001371429.1  interferon alpha/beta receptor 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      Consensus CDS
      CCDS93090.1
      UniProtKB/TrEMBL
      A0A8V8TQK8
      Related
      ENSP00000514786.1,ENST00000700084.1
      Conserved Domains (2)summary
      pfam09294
      Location:80 →176
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:22 →64
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. NM_001384501.1 →NP_001371430.1  interferon alpha/beta receptor 1 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      UniProtKB/TrEMBL
      C9J114
      Conserved Domains (2)summary
      pfam09294
      Location:126 →224
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:20 →114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. NM_001384502.1 →NP_001371431.1  interferon alpha/beta receptor 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      Related
      ENST00000700086.1
      Conserved Domains (2)summary
      pfam09294
      Location:1 →70
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:74 →164
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. NM_001384503.1 →NP_001371432.1  interferon alpha/beta receptor 1 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      Consensus CDS
      CCDS93088.1
      UniProtKB/TrEMBL
      A0A994J6F6,C9J114
      Related
      ENSP00000515373.1,ENST00000703557.1
      Conserved Domains (2)summary
      pfam09294
      Location:126 →224
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:20 →114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    8. NM_001384504.1 →NP_001371433.1  interferon alpha/beta receptor 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AP000296, AP000297, AP000298
      Consensus CDS
      CCDS93089.1
      Related
      ENSP00000498654.1,ENST00000652450.2
      Conserved Domains (2)summary
      pfam09294
      Location:57 →155
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:159 →249
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build.Explain

    This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      33324395..33359864
      Download
      GenBank,FASTA,Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31696639..31732109
      Download
      GenBank,FASTA,Sequence Viewer (Graphics)
    NucleotideProtein
    HeadingAccession and Version
    Protein AccessionLinks
    GenPept LinkUniProtKB Link
    P17181.3GenPeptUniProtKB/Swiss-Prot:P17181

    Gene LinkOut

    The followingLinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases

    Supplemental Content

    Genome Browsers

    Related information

    Subscription

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Follow NCBI
    [8]ページ先頭
    ©2009-2026 Movatter.jp