Anthony Edwards had five points on 2-for-5 from the field before exiting Sunday’s game against the Pacers.

MINNEAPOLIS (AP) — Minnesota Timberwolves star Anthony Edwards exited early in the first quarter of the home opener with tightness in his right hamstring on Sunday night, and the team announced he would not return.

Edwards converted a tough layup in traffic off a fast break with 3:07 elapsed in the game against Indiana, taking hard contact before he looked for a foul call to no avail. The Pacers called timeout one second later, and Bones Hyland subbed in for Edwards during the break.

Edwards was listed as questionable to play in Minnesota’s season opener at Portland on Wednesday night, when he had 41 points in 39 minutes. The three-time All-Star has played in 426 of a possible 445 games, including the playoffs, in his career.