Featured
Nature Video |
These mysterious ridges could be the secret to younger skinRete ridges could hold the secrets to revitalising skin.
- Nick Petrić Howe
Editorial |
Now is not the time to defund human fetal tissue researchHindering studies involving fetal tissue will impede the development of the alternatives intended to replace it, while slowing the search for new medicines.
Outlook |
Could the regenerative power of the lungs help to reverse disease?The ability of the lungs to rebuild themselves has long been underappreciated, now researchers are raising the possibility that it could help to tackle chronic disease.
- Claire Ainsworth
Article
|Open Access
Human assembloids recapitulate periportal liver tissue in vitroHepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.
- Lei Yuan
- ,Sagarika Dawka
- & Meritxell Huch
Article
|Open Access
Human gut M cells resemble dendritic cells and present gluten antigenAn intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune system via the class II major histocompatibility complex.
- Daisong Wang
- ,Sangho Lim
- & Hans Clevers
News & Views |
Primate embryo model leaps across developmental boundariesA stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development.
- Xiangyu Kong
- & Thorold W. Theunissen
Article |
Modelling late gastrulation in stem cell-derived monkey embryo modelsAn optimized 3D culture system enabled a stem cell-derived monkey blastoid to develop to day 25, recapitulating key events of primate late gastrula and demonstrating notable similarity to natural embryos.
- Jie Li
- ,Jie Li
- & Zhen Liu
News & Views |
Ancient viral DNA in the human genome shapes early developmentStem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
- Sherif Khodeer
- & Vincent Pasque
Article |
Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.
- Fangtao Chi
- ,Qiming Zhang
- & Ömer H. Yilmaz
Article
|Open Access
A human-specific regulatory mechanism revealed in a pre-implantation modelGenetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
- Raquel Fueyo
- ,Sicong Wang
- & Joanna Wysocka
News Feature |
The mini placentas and ovaries revealing the basics of women’s healthLab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.
- Cassandra Willyard
Article |
Human gastroids to model regional patterning in early stomach developmentNeural tissue is a key signalling centre for fundic–antral patterning in development of gastric organoids featuring asymmetric PDX1 patterning.
- Xia Li
- ,Feng Lin
- & Yue Shao
News |
Hope for diabetes: CRISPR-edited cells pump out insulin in a person — and evade immune detectionEdits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.
- Elie Dolgin
Outlook |
Will the latest skin substitutes revolutionize the treatment of burns and other wounds?Engineered multilayered tissues are showing great promise in the clinic, and could also provide more-accurate models for studying skin disease.
- Michael Eisenstein
Article
|Open Access
Haematopoietic stem cell number is not solely defined by niche availabilityHaematopoietic stem cell numbers are restricted at both systemic and local levels.
- Shoichiro Takeishi
- ,Tony Marchand
- & Ulrich Steidl
Article |
Therapeutic genetic restoration through allogeneic brain microglia replacementBrain-restricted allogeneic transplantation of myeloid progenitors enables microglia replacement without the need for genetic engineering or systemic cytotoxic preconditioning.
- Marius Marc-Daniel Mader
- ,Alexa Scavetti
- & Marius Wernig
Research Highlight |
Ageing stem cells in the knees drive arthritis damageMice with a version of osteoarthritis experienced symptom relief after expression of a protein targeting a stem-cell receptor was blocked.
News |
Mini hearts, lungs and livers made in lab now grow their own blood vesselsThese sophisticated models will be used for human-development studies and drug testing.
- Smriti Mallapaty
Article
|Open Access
Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in miceA study presents a strategy based on human pluripotent stem cells for treating neurodegenerative disorders of the gastrointestinal tract.
- Homa Majd
- ,Ryan M. Samuel
- & Faranak Fattahi
News |
‘Super-healing’ animals inspire human treatmentsStudies of the regenerative powers of worms, zebrafish and lizards suggest ways to improve recovery in people.
- Smriti Mallapaty
Article
|Open Access
Morphodynamics of human early brain organoid developmentHuman brain morphodynamics are explored using organoids.
- Akanksha Jain
- ,Gilles Gut
- & Barbara Treutlein
News |
Mice with human cells developed using ‘game-changing’ techniqueHuman cells injected into amniotic fluid find their way into fetal mouse organs.
- Smriti Mallapaty
News |
Tiny human hearts grown in pig embryos for the first timeThe hearts started to beat in the pig–human hybrids, which survived for 21 days.
- Smriti Mallapaty
Clinical Briefing |
Gene therapy could correct blood stem cells inside, rather than outside, the bodyExperiments in mice reveal an early postnatal window of opportunity for the effective transfer of genes to blood-cell-producing haematopoietic stem cells by injecting mice with gene-carrying lentiviral vectors. This approach showed therapeutic benefit in three mouse models of severe diseases, and could expand the applicability of haematopoietic stem-cell gene therapy in the clinic.
News & Views |
Mitochondrial molecule has unexpected role in tissue healingA key component of the TCA cycle, a series of reactions that occurs in energy-generating organelles called mitochondria, can dictate the fate of intestinal stem cells.
- Ram P. Chakrabarty
- & Navdeep S. Chandel
Article
|Open Access
Metabolic adaptations direct cell fate during tissue regenerationMetabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering insights for targeted regenerative therapies.
- Almudena Chaves-Perez
- ,Scott E. Millman
- & Scott W. Lowe
Article
|Open Access
Mouse liver assembloids model periportal architecture and biliary fibrosisAn organoid system comprising adult mouse hepatocytes, cholangiocytes and mesenchymal cells recapitulates liver morphology, biliary function and fibrotic pathology, providing a new model for studies of hepatic biology.
- Anna M. Dowbaj
- ,Aleksandra Sljukic
- & Meritxell Huch
News & Views |
How axolotl cells ‘remember’ development to rebuild a lost limbThe molecular feedback loops that program positional identity as salamander limbs develop and regrow could be harnessed for regenerative medicine.
- S. Y. Celeste Wu
- & Jessica L. Whited
Article
|Open Access
Clonal tracing with somatic epimutations reveals dynamics of blood ageingThe discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.
- Michael Scherer
- ,Indranil Singh
- & Lars Velten
Article
|Open Access
Molecular basis of positional memory in limb regenerationA molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.
- L. Otsuki
- ,S. A. Plattner
- & E. M. Tanaka
News |
Stem cells coaxed into most advanced amniotic sacs ever grown in the labThe sacs grew to roughly 2 centimetres wide and could be used to study early pregnancy.
- Smriti Mallapaty
Article |
Oncogenic fusions converge on shared mechanisms in initiating astroblastomaThe molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalon neural progenitors, which leads to oncogenesis.
- Yixing Shi
- ,Qianqian Sun
- & Yang Yu
Article |
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosisInhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.
- Sangkyun Cho
- ,Siyeon Rhee
- & Joseph C. Wu
News & Views |
Clinical trials test the safety of stem-cell therapy for Parkinson’s diseaseTransplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its effectiveness.
- Hideyuki Okano
Editorial |
Don’t rush promising stem-cell therapiesPotential treatments need to be subject to the highest standards of safety and efficacy.
News & Views |
Age-related blood condition counteracted with a common diabetes drugMetformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
- Elmira Khabusheva
- & Margaret A. Goodell
News Feature |
Japan’s big bet on stem-cell therapies might soon pay off with medical breakthroughsInduced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner.
- Smriti Mallapaty
News |
‘Big leap’ for Parkinson’s treatment: symptoms improve in stem-cell trialsStudies show the therapy is safe, but bigger trials are needed to prove its efficacy.
- Smriti Mallapaty
Article
|Open Access
Mitochondrial metabolism sustainsDNMT3A-R882-mutant clonal haematopoiesisMetformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slowDNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid leukaemia.
- Malgorzata Gozdecka
- ,Monika Dudek
- & George S. Vassiliou
Article |
Metformin reduces the competitive advantage ofDnmt3aR878H HSPCsDnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.
- Mohsen Hosseini
- ,Veronique Voisin
- & Steven M. Chan
Article |
Multi-zonal liver organoids from human pluripotent stem cellsLiver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.
- Hasan Al Reza
- ,Connie Santangelo
- & Takanori Takebe
Article
|Open Access
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s diseaseAfter transplantation into the brain of patients with Parkinson’s disease, allogeneic dopaminergic progenitors derived from induced pluripotent stem cells survived, produced dopamine and did not form tumours, therefore suggesting safety and potential clinical benefits for Parkinson’s disease.
- Nobukatsu Sawamoto
- ,Daisuke Doi
- & Jun Takahashi
Article |
Generation of human adult hepatocyte organoids with metabolic functionsThe combined activation of Wnt and STAT3 signalling enables long-term self-renewal of human hepatocyte organoids, maintaining hepatic identity, supporting gene editing and offering therapeutic potential for liver disease through enhanced functionality, structure and metabolic competency.
- Ryo Igarashi
- ,Mayumi Oda
- & Toshiro Sato
Article
|Open Access
Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s diseaseBilateral grafts of cryopreserved human embryonic stem cell-derived dopaminergic neuron progenitor cells into the putamen of patients with Parkinson’s disease in a phase I clinical trial showed safety, improvements in off-drug motor function and graft survival at 18 months after transplant.
- V. Tabar
- ,H. Sarva
- & C. Henchcliffe
News |
Brain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in ratsNeurons engineered to evade the immune system could work as cell-replacement therapy.
- Dyani Lewis
Article
|Open Access
Human assembloid model of the ascending neural sensory pathwayA human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.
- Ji-il Kim
- ,Kent Imaizumi
- & Sergiu P. Pașca
Outlook |
The search for solutions to geographic atrophy of the retinaMomentum is building behind a variety of therapies that can slow, stop or even reverse the most advanced form of the eye condition age-related macular degeneration.
- Anthony King
Article
|Open Access
Clonal dynamics and somatic evolution of haematopoiesis in mouseIsolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using laboratory mice to study stem cell ageing.
- Chiraag D. Kapadia
- ,Nicholas Williams
- & Jyoti Nangalia
Perspective |
MorPhiC Consortium: towards functional characterization of all human genesThis Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated with null alleles of all human genes.
- Mazhar Adli
- ,Laralynne Przybyla
- & Justina Žurauskienė
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