Spatial transcriptomics of pulmonary fibrosis
Spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with disease.
Featured
The transcriptomic architecture of common cancers reflects synthetic lethal interactions
Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.
- Syed Haider
- Rachel Brough
- Christopher J. Lord
LetterOpen Access
Multiomic single-cell profiling identifies critical regulators of postnatal brain
Simultaneous profiling of RNA and chromatin accessibility in single nuclei isolated from human postnatal brain regions from infancy to late adulthood identifies key cellular regulators and nominates target genes and mechanisms for brain-related diseases and disorders.
- Tereza Clarence
- Jaroslav Bendl
- Panos Roussos
Article
Functional analysis of cancer-associated germline risk variants
Analysis of 4,041 single-nucleotide variants (SNVs) linked to 13 cancers performed in primary human cell types identifies 380 potentially regulatory SNVs and their putative target genes. Editing one SNV,rs10411210, revealed that the risk allele increases RHPN2 expression and stimulus-responsive RhoA activation.
- Laura N. Kellman
- Poornima H. Neela
- Paul A. Khavari
Article
Origin and de novo domestication of sweet orange
Genomic analyses ofCitrus species including haplotype-resolved genomes ofCitrus sinensis andCitrus aurantium highlight the origin of sweet orange and provide a strategy for de novo domestication of perennial crops.
- Shengjun Liu
- Yuantao Xu
- Qiang Xu
ArticleOpen Access
Announcements
A call for papers on "Diversity in Human Genetics"
Nature Genetics, along with other Springer Nature journals, will publish a collection of genetic studies focusing on diverse human populations, including but not limited to complex trait association studies, rare variant studies, population genetics and bioinformatic methods. We will also consider Reviews, Perspectives, and Comments addressing these topics.
Open for submissions
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The genome and GeneBank genomics of allotetraploidNicotiana tabacum provide insights into genome evolution and complex trait regulation
Chromosome-level genome assemblies of allotetraploidNicotiana tabacum and its ancestors, along with their transcriptomes, epigenomes and genotype and phenotype data for 5,196N. tabacum germplasms, provide insights into genome evolution and complex trait regulation.
- Yanjun Zan
- Shuai Chen
- Aiguo Yang
ArticleOpen Access
Rare loss-of-function variants inHECTD2 andAKAP11 confer risk of bipolar disorder
Analysis of whole-genome sequencing data from Iceland and the UK Biobank identifies an excess burden of rare loss-of-function variants inHECTD2 andAKAP11 in individuals diagnosed with bipolar disorder.
- Thorgeir E. Thorgeirsson
- Vinicius Tragante
- Kari Stefansson
ArticleOpen Access
A likelihood-based framework for demographic inference from genealogical trees
gLike infers population demographic histories with a variety of complex admixture events by analysis of graphs of states, which conceptualize the relationships of all lineages found in trees encoded in the ancestral recombination graph.
- Caoqi Fan
- Jordan L. Cahoon
- Charleston W. K. Chiang
Article
The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project
The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.
Perspective- Lingzhao Fang
- Jinyan Teng
- Curtis P. Van Tassell
Unraveling the role of succinyl-CoA in tumor immunity
The study highlights the crucial role of succinyl-CoA in tumor immunity by inducing the succinylation of PD-L1. We identified the succinyltransferase CPT1A as a potential therapeutic target. CPT1A could be a valuable biomarker for evaluating the efficacy of anti-PD-1 therapy and suggests a promising treatment strategy.
Research Briefing
Revealing the distinct genomic features of Japanese soybeans
Japanese soybeans have been bred for centuries for traditional soy-based food production. A pangenome study using genome data from 462 soybeans worldwide revealed distinct genomic features in Japanese soybeans, as well as several quantitative trait loci alleles that are important for breeding cultivars suited to traditional soy-based foods.
Research Briefing
Novel mRNA isoforms in human microglia refine genetic associations with neurodegeneration
Long-read RNA sequencing of human microglia expands the catalog of mRNA isoforms in this important cell type and assists with the interpretation of genetic associations with Alzheimer’s disease and Parkinson’s disease.
Research Briefing
Mass spectrometry-based mapping of plasma protein QTLs in children and adolescents
Mass spectrometry-based proteomics demonstrated its increasing analytical power and unique strengths in measuring genome-wide plasma proteomes and identifying protein quantitative trait loci (pQTLs), as reported in a study of over 3,000 Danish children and adolescents.
News & Views- Yansheng Liu
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data
In this era of rapidly expanding human genomics in research and healthcare, efficient data reuse is essential to maximize benefits for society. In response, the Federated European Genome–Phenome Archive (FEGA) was launched in 2022, and as of 2024, the FEGA network was composed of seven national nodes. Here we describe the complexities, challenges and achievements of FEGA, unravelling the dynamic interplay of regulatory frameworks, technical challenges and the shared vision of advancing genomic research.
- Teresa D’Altri
- Mallory Ann Freeberg
- Thomas M. Keane
Comment
Trending - Altmetric
A structured coalescent model reveals deep ancestral structure shared by all modern humans
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
The landscape of N6-methyladenosine in localized primary prostate cancer
Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder
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