| 2020 | AL Division Series | Houston | Lost, 1-3 |
| AL Wild Card Series | Chicago | Won, 2-1 |
| 2019 | AL Wild Card | Tampa Bay | Lost, 1-5 |
| 2018 | AL Wild Card | New York | Lost, 2-7 |
| 2014 | AL Wild Card | Kansas City | Lost, 8-9 |
| 2013 | AL Division Series | Detroit | Lost, 2-3 |
| 2012 | AL Division Series | Detroit | Lost, 2-3 |
| 2006 | AL Championship Series | Detroit | Lost, 0-4 |
| AL Division Series | Minnesota | Won, 3-0 |
| 2003 | AL Division Series | Boston | Lost, 2-3 |
| 2002 | AL Division Series | Minnesota | Lost, 2-3 |
| 2001 | AL Division Series | New York | Lost, 2-3 |
| 2000 | AL Division Series | New York | Lost, 2-3 |
| 1992 | AL Championship Series | Toronto | Lost, 2-4 |
| 1990 | World Series | Cincinnati | Lost, 0-4 |
| AL Championship Series | Boston | Won, 4-0 |
| 1989 | World Series | San Francisco | Won, 4-0 |
| AL Championship Series | Toronto | Won, 4-1 |
| 1988 | World Series | Los Angeles | Lost, 1-4 |
| AL Championship Series | Boston | Won, 4-0 |
| 1981 | AL Championship Series | New York | Lost, 0-3 |
| AL Division Series | Kansas City | Won, 3-0 |
| 1975 | AL Championship Series | Boston | Lost, 0-3 |
| 1974 | World Series | Los Angeles | Won, 4-1 |
| AL Championship Series | Baltimore | Won, 3-1 |
| 1973 | World Series | New York | Won, 4-3 |
| AL Championship Series | Baltimore | Won, 3-2 |
| 1972 | World Series | Cincinnati | Won, 4-3 |
| AL Championship Series | Detroit | Won, 3-2 |
| 1971 | AL Championship Series | Baltimore | Lost, 0-3 |
| 1931 | World Series (Philadelphia A's) | St. Louis | Lost, 4-3 |
| 1930 | World Series (Philadelphia A's) | St. Louis | Won, 4-2 |
| 1929 | World Series (Philadelphia A's) | Chicago | Won, 4-1 |
| 1914 | World Series (Philadelphia A's) | Boston | Lost, 0-4 |
| 1913 | World Series (Philadelphia A's) | New York | Won, 4-1 |
| 1911 | World Series (Philadelphia A's) | New York | Won, 4-2 |
| 1910 | World Series (Philadelphia A's) | Chicago | Won, 4-1 |
| 1905 | World Series (Philadelphia A's) | New York | Lost, 1-4 |
