Movatterモバイル変換

Entry

D08222                      Drug

Name

Milnacipran (INN)

Formula

C15H22N2O

Exact mass

246.1732

Mol weight

246.35

Structure

Simcomp

Class

Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)

Remark

ATC code:

N06AX17

Chemical structure group:

DG00960

Product (DG00960):

D01107<JP/US>

Efficacy

Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)

Comment

selective serotonin norepinephrine reuptake inhibitor (SNRI)

Target

SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]

Pathway

hsa04721

Synaptic vesicle cycle

hsa04726

Serotonergic synapse

Interaction

Structure map

map07027

Antidepressants

map07234

Neurotransmitter transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX17 Milnacipran
      D08222  Milnacipran (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran
    D08222  Milnacipran
Target-based classification of drugs [BR:br08310]
Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08222  Milnacipran (INN)
    SLC6A4 (HTT)
     D08222  Milnacipran (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00960  Milnacipran

Other DBs

CAS:	92623-85-3

PubChem:

96024910

PDB-CCD:

F0F[PDBj]

LigandBox:

D08222

NIKKAJI:

J304.816K

LinkDB

KCF data

ATOM        18
            1   C8x C    20.5100  -15.7500
            2   C8x C    20.5100  -17.1500
            3   C8x C    21.7000  -17.8500
            4   C8y C    22.9600  -17.1500
            5   C8x C    22.9600  -15.7500
            6   C8x C    21.7000  -15.0500
            7   C5a C    24.3600  -17.1500
            8   C1x C    22.9600  -19.6000
            9   C1y C    24.3600  -19.6000
            10  C1z C    23.6600  -18.3400
            11  C1b C    25.0600  -20.7900
            12  O5a O    24.3600  -15.7500
            13  N1c N    25.7600  -17.1500
            14  C1b C    26.4600  -15.9600
            15  C1b C    26.4600  -18.3400
            16  C1a C    27.8600  -18.3400
            17  C1a C    27.8600  -15.9600
            18  N1a N    26.4600  -20.7900
BOND        19
            1     8  10 1
            2    10   9 1
            3     3   4 2
            4     9  11 1 #Up
            5    10   4 1 #Down
            6    10   7 1
            7     4   5 1
            8     7  12 2
            9     5   6 2
            10    7  13 1
            11    6   1 1
            12   13  14 1
            13   13  15 1
            14   15  16 1
            15    1   2 2
            16   14  17 1
            17    2   3 1
            18   11  18 1
            19    8   9 1

» Japanese version » Back

DBGET integrated database retrieval system