| Entry | |
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| Name | Mirtazapine (JAN/USP/INN); Remeron (TN); Reflex (TN) |
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| Product | |
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| Generic | MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (ATLANTIC BIOLOGICALS CORP.), MIRTAZAPINE (Advanced Rx Pharmacy of Tennessee), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Apotex Corp.), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurolife Pharma LLC), MIRTAZAPINE (AvKARE), MIRTAZAPINE (AvKARE), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Coupler LLC), MIRTAZAPINE (Direct_Rx), MIRTAZAPINE (Direct_Rx), MIRTAZAPINE (Golden State Medical Supply), MIRTAZAPINE (Major Pharmaceuticals), MIRTAZAPINE (McKesson Corporation dba SKY Packaging), MIRTAZAPINE (Mylan Institutional), MIRTAZAPINE (Mylan Pharmaceuticals), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NorthStar Rx LLC), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (Prasco Laboratories), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (Rising Pharma Holdings), MIRTAZAPINE (Rising Pharma Holdings), MIRTAZAPINE (SQUARE PHARMACEUTICALS LIMITED), MIRTAZAPINE (Sun Pharmaceutical Industries), MIRTAZAPINE (Viona Pharmaceuticals) |
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| Formula | C17H19N3
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| Exact mass | 265.1579
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| Mol weight | 265.35
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| Structure | 
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| Simcomp | |
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| Class | Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01465 alpha-Adrenergic receptor antagonist DG01460 alpha2-Adrenergic receptor antagonist Neuropsychiatric agent DG01729 Tetracyclic antidepressant DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA) Gastrointestinal agent DG01489 5-HT3-receptor antagonist Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG01644 CYP2D6 substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate
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| Remark | | Therapeutic category: | 1179 |
| Product (DG02838): | D00563<JP/US> |
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| Efficacy | Antidepressant, Serotonin receptor antagonist |
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| Disease | Major depressive disorder [DS: H01646] |
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| Comment | NaSSA: Noradrenergic and specific serotonergic antidepressant
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| Target | |
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| Pathway | | hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism | Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576] |
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| Interaction | |
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| Structure map | |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N06 PSYCHOANALEPTICS N06A ANTIDEPRESSANTS N06AX Other antidepressants N06AX11 Mirtazapine D00563 Mirtazapine (JAN/USP/INN) <JP/US> USP drug classification [BR:br08302] Antidepressants Antidepressants, Other Mirtazapine D00563 Mirtazapine (JAN/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 117 Psychotropics 1179 Others D00563 Mirtazapine (JAN/USP/INN) Drug groups [BR:br08330] Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01465 alpha-Adrenergic receptor antagonist DG01460 alpha2-Adrenergic receptor antagonist DG02838 Mirtazapine D00563 Mirtazapine Neuropsychiatric agent DG01729 Tetracyclic antidepressant DG02838 Mirtazapine D00563 Mirtazapine DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA) DG02838 Mirtazapine D00563 Mirtazapine Gastrointestinal agent DG01489 5-HT3-receptor antagonist DG02838 Mirtazapine D00563 Mirtazapine Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG02838 Mirtazapine D00563 Mirtazapine DG01644 CYP2D6 substrate DG02838 Mirtazapine D00563 Mirtazapine DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG02838 Mirtazapine D00563 Mirtazapine Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRA2 D00563 Mirtazapine (JAN/USP/INN) <JP/US> Serotonin HTR2 D00563 Mirtazapine (JAN/USP/INN) <JP/US> Ion channels Ligand-gated ion channels Serotonin HTR3 D00563 Mirtazapine (JAN/USP/INN) <JP/US> New drug approvals in Japan [br08318.html] Drugs with new active ingredients D00563 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00563 Drug groups [BR:br08330] Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01465 alpha-Adrenergic receptor antagonist DG01460 alpha2-Adrenergic receptor antagonist DG02838 Mirtazapine Neuropsychiatric agent DG01729 Tetracyclic antidepressant DG02838 Mirtazapine DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA) DG02838 Mirtazapine Gastrointestinal agent DG01489 5-HT3-receptor antagonist DG02838 Mirtazapine Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG02838 Mirtazapine DG01644 CYP2D6 substrate DG02838 Mirtazapine DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG02838 Mirtazapine
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| Other DBs | |
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| LinkDB | |
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| KCF data | ATOM 20 1 C1y C 9.7476 -8.2180 2 N1y N 11.1496 -8.2180 3 C8y C 11.9909 -7.1665 4 C8y C 11.7105 -5.7644 5 C8y C 8.9064 -7.1665 6 C1x C 10.4486 -5.2036 7 C8y C 9.1868 -5.7644 8 C8x C 7.5744 -7.5871 9 C8x C 6.5229 -6.6056 10 C8x C 6.8033 -5.2737 11 C8x C 8.1353 -4.8531 12 C8x C 12.6919 -4.8531 13 C8x C 14.0238 -5.2737 14 C8x C 14.3743 -6.6056 15 N5x N 13.3228 -7.5170 16 C1x C 11.8507 -9.4097 17 C1x C 11.1496 -10.6715 18 N1y N 9.8177 -10.6715 19 C1x C 9.0466 -9.4798 20 C1a C 9.1167 -11.9334 BOND 23 1 3 4 1 2 1 5 1 3 4 6 1 4 2 3 1 5 5 7 2 6 1 2 1 7 6 7 1 8 5 8 1 9 8 9 2 10 9 10 1 11 10 11 2 12 7 11 1 13 4 12 2 14 12 13 1 15 13 14 2 16 14 15 1 17 3 15 2 18 2 16 1 19 16 17 1 20 17 18 1 21 18 19 1 22 1 19 1 23 18 20 1
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