| Entry | |
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| Name | Miconazole (JP18/USP/INN);
Monistat (TN);
Oravig (TN) |
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| Product | |
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| Formula | C18H14Cl4N2O
|
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| Exact mass | 413.9860
|
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| Mol weight | 416.12
|
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| Structure | 
|
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| Simcomp | |
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| Class | Antifungal
DG01883 Imidazole antifungal
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
|
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| Remark | | Therapeutic category: | 6290 |
| Product (DG00004): | D00416<JP/US> D00882<JP/US> |
|
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| Efficacy | Antifungal, Ergosterol biosynthesis inhibitor |
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| Disease | Oropharyngeal candidiasis [DS: H00363] |
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| Comment | Imidazole derivative
|
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| Target | sterol 14alpha-demethylase [KO: K05917] |
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| Pathway | |
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| Interaction | |
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| Structure map | |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AB Antiinfectives and antiseptics for local oral treatment
A01AB09 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AC Imidazole derivatives
A07AC01 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC02 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AF Imidazole derivatives
G01AF04 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AB Imidazole derivatives
J02AB01 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA13 Miconazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antifungals
Miconazole
D00416 Miconazole (JP18/USP/INN)
Dermatological Agents
Topical Anti-infectives
Antifungals, Dermatological
Miconazole
D00416 Miconazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D00416 Miconazole (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
Inorganic and organic chemicals
Miconazole
D00416 Miconazole (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Miconazole
D00416 Miconazole (JP18/USP/INN)
Drug groups [BR:br08330]
Antifungal
DG01883 Imidazole antifungal
DG00004 Miconazole
D00416 Miconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00004 Miconazole
D00416 Miconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG00004 Miconazole
D00416 Miconazole
Drug classes [BR:br08332]
Antifungal
DG01883 Imidazole antifungal
D00416 Miconazole
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Imidazole
D00416 Miconazole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00416 Miconazole
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00416
Drug groups [BR:br08330]
Antifungal
DG01883 Imidazole antifungal
DG00004 Miconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00004 Miconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG00004 Miconazole
Antimicrobials abbreviations [BR:br08327]
Antifungals
Ergosterol biosynthesis inhibitor
Imidazole
DG00004 Miconazole
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| Other DBs | |
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| LinkDB | |
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| KCF data |
ATOM 25
1 C8y C 11.4100 -9.5200
2 C8x C 11.4100 -10.9200
3 C8y C 12.6224 -11.6200
4 C8y C 13.8349 -10.9200
5 C8x C 13.8349 -9.5200
6 C8x C 12.6224 -8.8200
7 C1b C 15.0724 -11.6200
8 O2a O 16.2849 -10.9200
9 C1c C 17.4973 -11.6200
10 C1b C 18.7097 -10.9200
11 N4y N 19.9222 -11.6200
12 X Cl 12.6224 -13.0198
13 X Cl 10.1976 -8.8200
14 C8y C 17.4973 -13.0200
15 C8y C 16.2869 -13.7188
16 C8x C 16.2869 -15.1188
17 C8y C 17.4993 -15.8188
18 C8x C 18.7097 -15.1200
19 C8x C 18.7097 -13.7200
20 X Cl 15.0924 -13.0290
21 X Cl 17.4993 -17.2200
22 C8x C 19.9222 -13.0200
23 N5x N 21.2537 -13.4526
24 C8x C 22.0766 -12.3200
25 C8x C 21.2537 -11.1874
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 3 12 1
13 1 13 1
14 9 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 17 18 1
19 18 19 2
20 14 19 1
21 15 20 1
22 17 21 1
23 11 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 11 25 1
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