| Entry | |
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| Name | Indomethacin (USP);
Indometacin (JP18/INN);
Aconip (TN);
Indocin (TN) |
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| Product | |
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| Generic | INDOCIN (Zyla Life Sciences US), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (ANI Pharmaceuticals), INDOMETHACIN (Advanced Rx Pharmacy of Tennessee), INDOMETHACIN (American Health Packaging), INDOMETHACIN (Amneal Pharmaceuticals LLC), INDOMETHACIN (Amneal Pharmaceuticals NY LLC), INDOMETHACIN (Asclemed USA), INDOMETHACIN (Asclemed USA), INDOMETHACIN (AvPAK), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Chartwell RX), INDOMETHACIN (Chartwell RX), INDOMETHACIN (DIRECT RX), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Hikma Pharmaceuticals USA), INDOMETHACIN (KVK-Tech), INDOMETHACIN (NorthStar RxLLC), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (ST. MARY'S MEDICAL PARK PHARMACY), INDOMETHACIN (Sportpharm), INDOMETHACIN (St. Mary's Medical Park Pharmacy), INDOMETHACIN (XLCare Pharmaceuticals), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Pharmaceuticals USA), INDOMETHACIN (Zydus Pharmaceuticals USA) |
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| Formula | C19H16ClNO4
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| Exact mass | 357.0768
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| Mol weight | 357.79
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| Structure | 
|
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| Simcomp | |
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| Class | Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivative
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| Remark | | Product (DG00241): | D00141<JP/US> D01565<JP> D02110<JP> |
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| Efficacy | Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
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| Disease | Rheumatoid arthritis [DS: H00630] Ankylosing spondylitis [DS: H01674] Acute gouty arthritis [DS: H01532] |
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| Comment | Indole acetic acid derivative
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| Target | |
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| Pathway | |
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| Interaction | |
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| Structure map | |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EB Other cardiac preparations
C01EB03 Indometacin
D00141 Indomethacin (USP) <JP/US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB01 Indometacin
D00141 Indomethacin (USP) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA23 Indometacin
D00141 Indomethacin (USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC01 Indometacin
D00141 Indomethacin (USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Indomethacin
D00141 Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1145 Indomethacins
D00141 Indomethacin (USP); Indometacin (JP18/INN)
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D00141 Indomethacin (USP); Indometacin (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00141 Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Indometacin
D00141 Indomethacin (USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivative
DG00241 Indometacin
D00141 Indomethacin
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00141 Indomethacin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00141 Indomethacin (USP) <JP/US>
PTGS2 (COX2)
D00141 Indomethacin (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00141 Indometacin
D00141 Indometacin capsules
D00141 Indometacin suppositories
Prodrugs [br08324.html]
D00141
Rx-to-OTC switch list in Japan [br08314.html]
D00141
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivative
DG00241 Indometacin
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| Other DBs | |
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| LinkDB | |
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| KCF data |
ATOM 25
1 C8y C 23.8648 -19.0768
2 C8y C 23.8564 -20.5490
3 C1a C 25.1409 -21.2966
4 C6a C 26.4256 -19.0915
5 C1b C 25.1494 -18.3439
6 C8y C 21.5264 -20.4363
7 C8y C 21.5264 -19.0827
8 N4y N 22.7025 -21.1172
9 C8x C 20.3428 -21.1031
10 C8x C 20.3428 -18.3946
11 C5a C 22.7118 -22.4351
12 C8x C 19.1807 -20.4363
13 C8y C 19.1807 -19.0827
14 C8y C 21.9087 -22.9293
15 O2a O 18.0197 -18.4158
16 C8x C 20.7461 -22.2186
17 C8x C 21.8611 -24.2805
18 C1a C 16.8577 -19.0968
19 C8x C 19.5535 -22.8588
20 C8x C 20.6841 -24.9202
21 C8y C 19.5286 -24.2071
22 X Cl 18.3219 -24.7917
23 O6a O 27.7101 -18.3588
24 O6a O 26.4256 -20.5638
25 O5a O 23.9557 -23.1242
BOND 27
1 2 3 1
2 6 7 2
3 6 8 1
4 6 9 1
5 7 1 1
6 7 10 1
7 8 2 1
8 8 11 1
9 9 12 2
10 10 13 2
11 11 14 1
12 13 15 1
13 14 16 2
14 14 17 1
15 15 18 1
16 16 19 1
17 17 20 2
18 19 21 2
19 21 22 1
20 12 13 1
21 20 21 1
22 4 5 1
23 4 23 1
24 5 1 1
25 4 24 2
26 1 2 2
27 11 25 2
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