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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
MGI:104719

70 phenotypes from 6 alleles in 8 genetic backgrounds

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Allelic Composition Genetic Background	Annotated Term	Reference
Ndst1^b2b2230Clo/Ndst1^b2b2230Clo C57BL/6J-Ndst1^b2b2230Clo	absent mandible	J:175213
	anencephaly	J:175213
	anophthalmia	J:175213
	atrioventricular septal defect	J:175213
	decreased mouth size	J:175213
	heart left ventricle hypertrophy	J:175213
	heart right ventricle hypertrophy	J:175213
	heterotaxia	J:175213
	hydronephrosis	J:175213
	interrupted aortic arch	J:175213
	kidney cyst	J:175213
	lowered ear position	J:175213
	omphalocele	J:175213
	persistent truncus arteriosus	J:175213
	proboscis	J:175213
	right aortic arch	J:175213
	thymus hypoplasia	J:175213
	vascular ring	J:175213
Ndst1^tm1.1Grob/Ndst1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normalhematopoietic system phenotype	J:155870
Ndst1^tm1.1Grob/Ndst1^tm1.1Grob involves: 129S1/Sv * 129X1/SvJ	abnormal eye morphology	J:130571
	absent lacrimal glands	J:130571
Ndst1^tm1.1Grob/Ndst1^tm1.1Grob involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal anterior commissure morphology	J:100425
	abnormal brain commissure morphology	J:100425
	abnormal brain development	J:100425
	abnormal CNS glial cell morphology	J:100425
	abnormal cranium morphology	J:100425
	abnormal diencephalon morphology	J:100425
	abnormal facial morphology	J:100425
	abnormal forebrain development	J:100425
	abnormal hippocampal commissure morphology	J:100425
	abnormal telencephalon morphology	J:100425
	absent facial bone	J:100425
	absent mandible	J:100425
	absent neurocranium	J:100425
	absent olfactory bulb	J:100425
	anophthalmia	J:100425
	aphakia	J:100425
	delayed bone ossification	J:100425
	iris coloboma	J:100425
	microphthalmia	J:100425
	midline cleft upper lip	J:100425
	perinatal lethality, complete penetrance	J:100425
	pituitary gland hypoplasia	J:100425
Ndst1^tm1Ekf/Ndst1^tm1Ekf involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal surfactant secretion	J:63996
	atelectasis	J:63996
	cyanosis	J:63996
	lethality throughout fetal growth and development, incomplete penetrance	J:63996
	neonatal lethality, complete penetrance	J:63996
	respiratory failure	J:63996
Ndst1^tm1Grob/Ndst1^tm1Grob H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	normalvision/eye phenotype	J:130571
Ndst1^tm1Grob/Ndst1^tm1Grob Tg(Pax6-cre,GFP)1Pgr/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal lacrimal gland development	J:130571
	absent lacrimal glands	J:130571
	microphthalmia	J:130571
Ndst1^tm1Hgx/Ndst1^tm1Hgx involves: 129S4/SvJae * C57BL/6	abnormal surfactant secretion	J:60280
	abnormal type II pneumocyte morphology	J:60280
	atelectasis	J:60280
	cyanosis	J:60280
	decreased alveolar lamellar body number	J:60280
	neonatal lethality, complete penetrance	J:60280
	respiratory distress	J:60280
	thick pulmonary interalveolar septum	J:60280
Ndst1^tm1Je/Ndst1^tm1Je Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal hepatocyte physiology	J:158299
Ndst1^tm1Je/Ndst1^tm1Je Tg(Tek-cre)1Ywa/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal diaphragm central tendon morphology	J:208012
	abnormal diaphragm morphology	J:208012
	abnormal leukocyte adhesion	J:100456
	abnormal leukocyte migration	J:100456
	abnormal septum transversum morphology	J:208012
	abnormal tendon cell morphology	J:208012
	abnormal tendon collagen fibril morphology	J:208012
	abnormal vascular development	J:208012
	decreased angiogenesis	J:208012
	decreased endothelial cell proliferation	J:208012
	decreased inflammatory response	J:100456
	diaphragmatic hernia	J:208012
	herniated liver	J:208012
	hypoxia	J:208012
	impaired leukocyte tethering or rolling	J:100456
	thin diaphragm muscle	J:208012

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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