Analysis ToolsMGI integrates comparative data on inbred strain characteristics including SNPs, polymorphisms, and quantitative phenotypes.
Strains Inbred strains of mice represent unique fixed genotypes that can be repeatedly accessed as homogeneous experimental individuals, with predictable phenotypes and defined allelic composition. Hundreds of inbredstrains of mice have been described and new strains continue to be developed, taking advantage of the rich genetic diversity among the existing strains and the ease with which the mouse genome can be manipulated. SNPs (single nucleotide polymorphisms) MGI provides comprehensive information about reference SNPs including the reference flanking sequence, assays that define the SNP, and gene/marker associations with their corresponding function class annotations. Each SNP detail page includes links to popular gene browsers including the MGI JBrowse Genome Browser. Other molecular polymorphisms MGI includes data onRFLP and PCR based polymorphisms. Probes and restriction enzymes used forRFLP analysis and primer sequences used for PCR are provided, with fragment sizes and variants for each strain tested. Links to these data can be found in the Polymorphisms section of gene and marker detail pages. Strain characteristics and historical origins MGI holds information on comparative strain characteristics as originally curated by Dr. Michael Festing. These narratives provide key phenotypic traits of major inbred strains, such as behavior, physiology, anatomy,drug responses, immunology, infection, and reproduction. The Genealogy of Inbred Strains provides a "pedigree" of relationships of strains since their origin. The GenealogyChart graphically displays the movement and development of inbred strains and is particularly useful in looking atdispersion of strains and how inbreeding (and allele fixation) occurred in relation to conserved sequence blocks observed in SNP analysis Data are fully referenced. |
| Detailed explanations for using Strains, SNPs & Polymorphisms query forms and tools: |
| Collaborators and Data Providers: Mouse SNP data in MGI are obtained from the dbSNP resource at NCBI The registered mouse strains in MGI include strains |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) | ||
| Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. | last database update 12/10/2024 MGI 6.24 |  |
