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Glossary Term

Glossary Term	Gain-of-function Mutation MGI Glossary
Definition	A type ofmutation in which the alteredgene product possesses a newmolecular function or a new pattern ofgene expression. Gain-of-function mutations are almost alwaysDominant orSemidominant. See also: Amorphic Mutation Antimorphic Mutation Hypermorphic Mutation Hypomorphic Mutation Loss-of-function Mutation Neomorphic Mutation Null Mutation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/07/2025 MGI 6.24