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Entry

2909              CDS       T01001

Symbol

ARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP

Name

(RefSeq) Rho GTPase activating protein 35

K05732

glucocorticoid receptor DNA-binding factor 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04510

Focal adhesion

hsa04611

Platelet activation

hsa04670

Leukocyte transendothelial migration

hsa04810

Regulation of actin cytoskeleton

Network

nt06167 Human cytomegalovirus (HCMV)

Element

N00393

ITGA/B-RhoGAP-RhoA signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2909 (ARHGAP35)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    2909 (ARHGAP35)
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    2909 (ARHGAP35)
   04670 Leukocyte transendothelial migration
    2909 (ARHGAP35)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2909 (ARHGAP35)
Membrane trafficking [BR:hsa04131]
Others
  Rho GTPase associated proteins
   Rho GTPase-activating proteins
    2909 (ARHGAP35)

SSDB

Motif

Pfam:

RhoGAP_pG1_pG2 RhoGAP FF_RHG35_4th RhoGAP-FF1 Ras FF GTP_EFTU Cdh1_DBD_1 NOG1

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

19:46860997..47005077

AA seq 1499 aa
MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLST
SDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRA
AATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKF
VSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAF
STLVQLIDKSRGKTKIIPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQ
ASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDH
LSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHL
EKLRNERKRVEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKH
QKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAER
DALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINL
VILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHG
CLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADV
DLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSVLSY
HSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDL
SREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEA
CSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHSKLSMELEGND
GLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQD
GFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDT
SSLERGRKVSIVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKG
DNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKP
IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGA
MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN
KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRP
ITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQAEHTL

NT seq 4500 nt +upstreamnt +downstreamnt
atgatgatggcaagaaagcaagatgtccgaattcccacctacaacatcagtgtggtggga
ttatctgggaccgagaaggaaaagggccagtgtgggattggaaagtcttgtttgtgcaac
cgcttcgtgcgcccgagtgctgacgagtttcacttggaccatacctccgtcctcagcacc
agtgactttggagggcgagtggtcaataatgaccactttctctactggggagaagttagc
cgctccctggaggattgtgtggaatgtaagatgcacattgtggagcagactgaatttatt
gatgatcagacttttcaacctcatcgaagcacggccctgcagccctatatcaagagagct
gctgcgaccaagcttgcatcagctgaaaaactcatgtacttttgcactgaccagctgggg
ctggagcaggactttgagcagaaacaaatgccagacggaaagctgctggttgatggtttt
cttcttggtattgatgttagcaggggcatgaataggaactttgatgaccagctcaagttt
gtctccaatctctacaatcagcttgcaaaaacaaaaaagcccatagtggtggtcctgact
aagtgtgacgaaggtgttgagcggtacattagagatgcacatacttttgccttaagcaaa
aagaacctccaggttgtggagacctcagcgagatccaatgtaaacgtggacttggctttc
agcaccttagtgcaactcattgataaaagtcggggaaagacaaaaatcattccttatttt
gaagctctcaagcagcagagtcagcagatagctacagcaaaagacaagtatgagtggctg
gtgagtcgcattgtgaaaaaccacaatgagaactggctgagtgtcagccgaaagatgcag
gcctctccagaataccaggactatgtctacctggaagggactcagaaagccaagaagctg
tttctacagcacatccaccgcctcaagcatgagcatatcgagcgtaggagaaagctgtac
ctggcagccctgccattagcttttgaagctcttatacctaatctagatgaaatagaccac
ctaagctgcataaaagccaaaaagctcttagaaaccaagccagaattcttgaagtggttt
gttgtgcttgaagagaccccatgggatgccaccagtcacattgacaacatggaaaacgaa
cggattccctttgatttaatggataccgtccctgcagagcagctatacgaggcccactta
gagaagctgaggaacgaaaggaaaagagttgagatgcgaagggcgtttaaagaaaacctg
gagacttctcctttcataactcccggaaagccttgggaagaggcccgtagttttattatg
aatgaggatttctaccagtggctggaggaatctgtatacatggatatttatggcaaacac
caaaagcaaattatagataaagcaaaggaagaatttcaggagttgcttttggaatattca
gaattgttttatgaactggagctggatgctaagcccagcaaggagaagatgggtgttatt
caggatgttctgggagaggaacagcgatttaaagcattacaaaagctccaagcagagcgt
gatgcccttattctgaaacacattcattttgtgtaccacccaacaaaggagacatgcccc
agctgcccagcttgtgtggacgctaagattgagcacttgattagttctcggtttatccgg
ccgtctgaccggaatcagaaaaattcactctctgaccctaacattgatagaatcaacttg
gttatattgggcaaagacggccttgcccgagagttggccaatgagattcgagctctttgt
acaaatgatgacaagtatgtgatagatggtaaaatgtatgagctttccctgaggccaata
gaggggaatgtcaggcttcctgtgaactctttccagacgccaacatttcagccccacggc
tgtctctgcctttacaattcaaaggaatcgctatcctatgtagtggaaagtatagagaag
agtagagagtccacgctgggccggcgggataatcatttagtccatctcccccttacatta
attttggttaacaagagaggagacaccagtggagagactctgcatagcttaatacagcaa
ggtcaacaaattgctagcaaacttcagtgtgtctttctcgaccctgcttctgctggcatt
ggttacggacgcaacattaatgaaaagcaaatcagtcaagttttgaagggactcctggac
tctaagcgtaacttaaacctggtcagttctactgctagcatcaaagatttggctgatgtt
gatctgcgaattgttatgtgtctgatgtgtggagatccttttagtgcagatgacatactt
tttcctgtccttcagtcccaaacctgtaaatcttcccattgtggaagcaacaactctgtt
ttacttgaactaccaatcggactgcacaagaagcggattgaactgtctgttctttcatac
cattcctcctttagcatcagaaagagccggttggttcatgggtacattgttttttattca
gccaaacgtaaggcctctttggctatgttacgtgcctttctttgtgaagtgcaggatatt
atccctattcagcttgtagcactcactgatggcgctgtagatgtcctggacaatgactta
agtagggaacagctaactgagggggaggagattgctcaagaaattgacggaaggttcaca
agcatcccctgtagccaaccccagcataaacttgagatctttcacccattttttaaagat
gtggtggaaaaaaagaacataatcgaggctactcatatgtacgataatgctgccgaggcc
tgtagcaccaccgaagaggtgtttaactccccccgggcaggatcaccgctctgcaactca
aacctgcaggattcagaagaagatatcgagccatcttacagcctgtttcgagaagacaca
tcactgccttctctgtccaaagaccattctaagctctctatggaactggagggaaatgat
gggctgtctttcattatgagcaattttgagagtaaactgaacaacaaagtacctccgcca
gtcaaaccaaagcctcctgtccattttgaaattacaaagggggatctatcttatttagac
caaggccatagggatggacagaggaagtctgtgtcttctagcccctggctgcctcaggat
gggtttgatccttctgactatgctgaacccatggatgctgtggtgaagccaaggaatgaa
gaagaaaacatatactccgtgccccatgacagcacccaaggcaaaatcatcaccattcgg
aatatcaacaaagcccagtccaacggcagcgggaatggttctgacagtgaaatggacacc
agctctctagagcgagggcgcaaggtttccatcgtgagcaagccagtgctgtacaggacg
agatgcacccggctggggcggtttgctagttaccggaccagcttcagcgtggggagtgat
gatgagctggggcccatccggaagaaagaggaggatcaggcatcccagggttataaaggg
gacaatgctgtcattccatacgaaacagacgaagacccgcggaggaggaatattcttcgc
agcctaaggaggaacactaagaaaccaaagcccaaaccccggccatccatcacaaaggca
acctgggagagtaactattttggggtgcccttaacaactgtcgtgactccagagaagccg
atccccatttttattgaaagatgtattgagtacattgaagccacaggactgagcacggaa
ggcatctaccgggtcagcgggaacaagtctgagatggagagtctgcagagacagtttgat
caagaccacaacctggacctggcagagaaagactttacggtgaataccgtggctggtgcc
atgaagagctttttctcagaactgcctgaccccctggtcccgtataacatgcagatcgac
ttggtggaagcacacaaaatcaacgaccgggagcagaagttgcatgcccttaaggaggta
ttaaagaaatttccaaaggaaaaccacgaagtcttcaagtatgtcatctctcacctaaac
aaggtcagccacaacaacaaggtgaatctcatgaccagcgagaacctctccatctgcttc
tggcccaccttgatgagacctgatttcagcactatggacgccctcacagccacgcgcacc
taccagacaatcattgaactctttatccagcagtgccccttcttcttctacaatcggccc
atcaccgagccccccggcgccaggcccagctccccctctgccgtggcttccaccgtcccc
ttcctcacttccacgcctgtcacaagtcagccgtcgcccccacagtcgcctccacccacc
ccccagtccccaatgcagccactgcttccctcccagcttcaagccgaacacacgctgtga

All links

Disease (1)OMIM (1)Gene (16)RefGene (10)NCBI-PROTEINID (1)NCBI-Gene (1)HGNC (1)Ensembl (1)RIKEN BRC-DNA (1)OC (1)Protein sequence (5)UniProt (1)SWISS-PROT (1)RefSeq(pep) (3)DNA sequence (36)RefSeq(nuc) (6)GenBank (15)EMBL (15)3D Structure (6)PDB (6)Protein domain (9)Pfam (9)All databases (73)
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